Results 41 to 50 of about 102,383 (324)

Adenosine‐to‐inosine editing of miR‐200b‐3p is associated with the progression of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira, Anna Skwarska, Karolina Chwialkowska, Agnieszka Ostrowska, Gabriela Sokolowska, Anna Zeller, Anna Erol, Andrzej Eljaszewicz, Bartosz Hanczaruk, Anna Michalska‐Falkowska, Agnieszka Tarasik, Joanna Reszec‐Gielazyn, Pawel Knapp, Marcin Moniuszko, Adam Kretowski   +14 more
wiley   +1 more source

Virtual element approximations of the time-fractional nonlinear convection-diffusion equation on polygonal meshes

Mathematics in Engineering
We extend the Virtual Element Method to a two-dimensional unsteady nonlinear convection-diffusion equation characterized by a fractional-order derivative with respect to the time variable.
Zaffar Mehdi Dar, M. Arrutselvi, Chandru Muthusamy, Sundararajan Natarajan, Gianmarco Manzini   +4 more
doaj   +1 more source

Local regularity for fractional heat equations

, 2017
We prove the maximal local regularity of weak solutions to the parabolic problem associated with the fractional Laplacian with homogeneous Dirichlet boundary conditions on an arbitrary bounded open set $\Omega\subset\mathbb{R}^N$.
D Lamberton, E Fernández-Cara, E Stein, G Grubb, Haim Brezis, Hans Triebel, L Miller, LC Evans, M Kassmann, OA Ladyzhenskaya, P Grisvard, S Micu, T Leonori, U Biccari, U Biccari, X Fernández-Real, X Ros-Oton   +16 more
core   +1 more source

Maximal Solutions of Sparse Analysis Regularization [PDF]

Journal of Optimization Theory and Applications, 2018
This paper deals with the non-uniqueness of the solutions of an analysis-Lasso regularization. Most of previous works in this area is concerned with the case where the solution set is a singleton, or to derive guarantees to enforce uniqueness. Our main contribution consists in providing a geometrical interpretation of a solution with a maximal D ...
Barbara, Abdessamad, Jourani, Abderrahim, Vaiter, Samuel   +2 more
openaire   +4 more sources

In vitro properties of patient serum predict clinical outcome after high dose rate brachytherapy of hepatocellular carcinoma

Molecular Oncology, EarlyView.
Following high dose rate brachytherapy (HDR‐BT) for hepatocellular carcinoma (HCC), patients were classified as responders and nonresponders. Post‐therapy serum induced increased BrdU incorporation and Cyclin E expression of Huh7 and HepG2 cells in nonresponders, but decreased levels in responders.
Lukas Salvermoser, Jan Niklas Schäfer, Shraga Nahum Goldberg, Philipp Maximilian Kazmierczak, Moritz Nikolaus Gröper, Philipp Franz Linden, Elif Öcal, Tanja Burkard, Stefanie Corradini, Najib Ben Khaled, Moritz Wildgruber, Max Seidensticker, Jens Ricke, Matthias Stechele, Marianna Alunni‐Fabbroni   +14 more
wiley   +1 more source

Maximal regularity for non-autonomous Cauchy problems in weighted spaces

Electronic Journal of Differential Equations, 2020
We consider the regularity for the non-autonomous Cauchy problem $$ u'(t) + A(t) u(t) = f(t)\quad (t \in [0, \tau]), \quad u(0) = u_0. $$ The time dependent operator A(t) is associated with (time dependent) sesquilinear forms on a Hilbert space ...
Achache Mahdi, Tebbani Hossni
doaj  

Non-Autonomous Maximal Regularity in Hilbert Spaces

, 2016
We consider non-autonomous evolutionary problems of the form $u'(t)+A(t)u(t)=f(t)$, $u(0)=u_0,$ on $L^2([0,T];H)$, where $H$ is a Hilbert space.
Dier, Dominik, Zacher, Rico
core   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Day/night variations of myeloid and lymphoid cell subsets in the murine inguinal lymph node

FEBS Open Bio, EarlyView.
The circadian system is involved in the temporal regulation of the immune system. Our study reveals that two innate immune populations, NKT cells and neutrophils, predominate at the beginning of the day in healthy mice, highlighting how the time of day influences immune responses.
Paula M. Wagner, César G. Prucca, Lucia Boffelli, Virginia A. Piqueras, Silvia G. Correa, Mariana Maccioni, Mario E. Guido   +6 more
wiley   +1 more source

Fractional Maximal Functions in Metric Measure Spaces

Analysis and Geometry in Metric Spaces, 2013
We study the mapping properties of fractional maximal operators in Sobolev and Campanato spaces in metric measure spaces. We show that, under certain restrictions on the underlying metric measure space, fractional maximal operators improve the Sobolev ...
Heikkinen Toni, Lehrbäck Juha, Nuutinen Juho, Tuominen Heli   +3 more
doaj   +1 more source