Impact of glucose metabolism on myocardial fibrosis and inflammation in hypertrophic cardiomyopathy: a cardiac MR study. [PDF]
Peng X +9 more
europepmc +1 more source
Integrative Omics Defines Metabolic Biomarkers and Genetic Regulatory Mechanisms of Mortality Risk
Understanding mortality mechanisms remains a fundamental challenge. Through multi‐omics analysis of a three‐generation chicken model, are identified 45,585 mQTLs and establish a 16‐metabolite predictor of mortality. An inflammation‐growth trade‐off and evolutionarily conserved pathways involving butyrate–microbiota interactions and L‐cysteine's dual ...
Peihao Liu +10 more
wiley +1 more source
Biomolecular Predictors of Recurrence Patterns and Survival in IDH-Wild-Type Glioblastoma: A Retrospective Analysis of Patients Treated with Radiotherapy and Temozolomide. [PDF]
Tini P +15 more
europepmc +1 more source
Current understanding of gastric cancer immunity remains inadequate, leading to suboptimal immunotherapy outcomes. This study introduces a novel tumor immune microenvironment classification system (Inflamed, Desert, and Excluded), advancing traditional histopathological or molecular subtyping toward a functional immunological framework.
Jianchao Wang +14 more
wiley +1 more source
Physical Exercise Before Long-Term Electrocardiogram May Enhance the Assessment of Nocturnal Heart Rate Variability in Young Individuals With Type 1 Diabetes Melltius. [PDF]
Fridolfsson C +3 more
europepmc +1 more source
Our research reveals that small‐molecule icariin (ICA) directly binds Ras‐GTPase‐activating protein SH3 domain‐binding protein 1 (G3BP1), inducing conformational change and oligomerization. This interaction confers neuroprotection by recruiting insulin‐like growth factor 2 mRNA‐binding protein 1 (IGF2BP1) and modulating N6‐methyladenosine (m6A ...
Ling Li +17 more
wiley +1 more source
A novel ECG marker for predicting left bundle branch area pacing success in left bundle branch block: notch/slur to QRS end duration. [PDF]
Cai M +8 more
europepmc +1 more source
Principles for Rigorous Design and Application of Synthetic Microbial Communities
SynComs are artificially designed to enable inter‐species metabolic interactions, metabolic division of labor, and ecological interactions that can elicit phenotypes like colonization stability and environmental adaptation. This systematic review explores the processes used to construct SynComs, the assessment of the mechanisms of metabolic interaction
Yuxiao Zhang +21 more
wiley +1 more source

