An approach to determining regional standards for the concentration of natural or anthropogenic substances in the coastal waters of southwestern Sakhalin, taking into account the natural hydrochemical background [PDF]
Геосистемы переходных зонPreserving stable functioning of coastal marine ecosystems under transforming anthropogenic impact requires an objective assessment of their ecological state.
@Koreneva, Tatiana G. +4 more
doaj +1 more source
A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma
FEBS Letters, EarlyView.Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos +9 more
wiley +1 more source
DNA ligase LigE increases bacterial transformation with damaged extracellular DNA
FEBS Letters, EarlyView.The DNA ligase LigE from the naturally competent Gram‐negative bacterium Neisseria gonorrhoaea increases transformation with cut extracellular DNA. This process is ATP‐dependent and relies on the catalytic activity of LigE; it also requires that LigE contains an intact periplasmic localisation sequence, indicating that ligE functions in the periplasm ...
Jolyn Pan +4 more
wiley +1 more source
Assessment of pollution of Azov sea bottom sediments with heavy metals
Известия высших учебных заведений: Геология и разведка, 2016 The assessment of the state of pollution of Azov sea bottom sediments with heavy metals - Pb, Cd, Cu, Zn, and Hg using the data of «Azovmorinformtsentr» (concentration of heavy metals in bottom sediments in 2010-2014) and published data for 1991-2009 is ...
M. V. Bufetova, O. N. Fen
doaj +2 more sources
Going viral − Virus‐targeting nanobodies for research, diagnostics and therapy
FEBS Letters, EarlyView.The increasing prevalence of viral diseases represents a major threat for global human health. Nanobodies, small binding fragments derived from camelid heavy‐chain antibodies, offer versatile tools for viral research, diagnostics, and antiviral therapy.
Domenic Ebert, Ulrich Rothbauer
wiley +1 more source
Unlocking the potential of cell‐permeable nanobodies for intracellular applications
FEBS Letters, EarlyView.This review outlines current strategies for delivery of nanobodies into cells and highlights recent examples of functional applications. By addressing and manipulating intracellular targets, these molecules hold great potential for treating cancer, respiratory diseases and neurological disorders, making this a vibrant area of research in the biomedical
Mariona Gené‐Verdés +2 more
wiley +1 more source
Design of Single Acceptance Sampling Plan Using Maximum Allowable Proportion Defective (MAPD) and Producer’s Allowable Risk (PAR) [PDF]
, 2016 This paper focuses on single acceptance sampling designs on incoming quality with Maximum Allowable percent Defective (MAPD) along with a specified probability of acceptance referred to Producer’s Allowable Risk (PAR) which is defined as the minimum ...
Waziri, Edokpa Idemudia +1 more
core
, 2013 Genome-wide promoter prediction performance comparison of different promoterprediction programs with maximum allowable distance of 500 bp from annotated TSS.
Sutapa Datta (379708) +1 more
core +1 more source
The maximum allowable bounds of σ2 for τd, σd and α of Example 5.
, 2022 The maximum allowable bounds of σ2 for τd, σd and α of Example 5.
Thongchai Botmart (12269559) +1 more
core +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source