Results 81 to 90 of about 105,583 (339)
A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression
Molecular Oncology, EarlyView.Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak +8 more
wiley +1 more source
Haematological parameters of the two-years-old carp under herbicides burden
Vìsnik Dnìpropetrovsʹkogo Unìversitetu: Serìâ Bìologìâ, Ekologìâ, 2006 Influence of different chemical herbicides in a concentration of 2 MAC (maximum allowable concentration) on changes of the basic haematological parameters and formation of adaptive reactions of two-years-old carp is presented. Mostly rapid and pronounced
A. A. Zhidenko
doaj +1 more source
Determining Sustainable Development Density using the Urban Carrying Capacity Assessment System [PDF]
, 2004 Diverse urban problems in the capital region of Korea occur due to over-development and over-concentration which exceed the region’s carrying capacity.
Jeong, Yeunwoo +3 more
core
Molecular Oncology, EarlyView.This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker +16 more
wiley +1 more source
Majallah-i ̒Ilmī-i Shīlāt-i Īrān, 2007 The impact of Sefidroud River sediments on the fingerlings of Persian Sturgeon (Acipenser persicus) was studied in 2005. The tests were done in 20 liter aquariums each containing 10 Persian Sturgeons fingerlings weighing 3-5 grams each.
M. Yosefi garakoei; Sh. Nezami; K. Mehdi nezhad; H. Khara; Z. Pazhand; M. Mohmmad nezhad
doaj
Molecular Oncology, EarlyView.This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad +17 more
wiley +1 more source
Keplerian frequency of uniformly rotating neutron stars and quark stars
, 2009 We calculate Keplerian (mass shedding) configurations of rigidly rotating neutron stars and quark stars with crusts. We check the validity of empirical formula for Keplerian frequency, f_K, proposed by Lattimer & Prakash, f_K(M)=C (M/M_sun)^1/2 (R/10km)^-
Akmal +34 more
core +1 more source
Aggressive prostate cancer is associated with pericyte dysfunction
Molecular Oncology, EarlyView.Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero +11 more
wiley +1 more source
RUDN Journal of Ecology and Life Safety, 2016 Compounds of lead and cadmium, possessing high toxicity, a cumulative inhibit production process, reduce a salad biomass gain. Research showed that oppression of root system was shown in reduction of number of small backs, and on the main roots there ...
A L Kravchenko +3 more
doaj
Molecular Oncology, EarlyView.Genetic testing in epithelial ovarian cancer includes both germline and tumor‐testing. This approach often duplicates resources. The current prospective study assessed the feasibility of tumor‐first multigene testing by comparing tumor tissue with germline testing of peripheral blood using an 18‐gene NGS panel in 106 patients.
Elisabeth Spenard +12 more
wiley +1 more source