Results 81 to 90 of about 2,530,894 (297)

Maximum Entropy Theory of Ecology: A Reply to Harte

open access: yesEntropy, 2018
In a paper published in this journal, I addressed the following problem: under which conditions will two scientists, observing the same system and sharing the same initial information, reach the same probabilistic description upon the application of the ...
Marco Favretti
doaj   +1 more source

Soft motions encoded by the fold and mediated by conserved hinge sites drive V‐ATPase allosteric machinery and autoinhibition

open access: yesFEBS Letters, EarlyView.
Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana   +3 more
wiley   +1 more source

Estimation of Cost Allocation Coefficients at the Farm Level Using an Entropy Approach [PDF]

open access: yes
This paper aims to estimate the farm cost allocation coefficients from whole farm input costs. An entropy approach was developed under a Tobit formulation and was applied to a sample of farms from the 2004 FADN data base for Alentejo region, Southern ...
Rui Fragoso, Maria Leonor Carvalho
core  

Maximum Entropy Approaches to Living Neural Networks

open access: yesEntropy, 2010
Understanding how ensembles of neurons collectively interact will be a key step in developing a mechanistic theory of cognitive processes. Recent progress in multineuron recording and analysis techniques has generated tremendous excitement over the ...
John M. Beggs   +7 more
doaj   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

open access: yesMolecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera   +11 more
wiley   +1 more source

Maximum Entropy Rate Reconstruction of Markov Dynamics

open access: yesEntropy, 2015
We develop ideas proposed by Van der Straeten to extend maximum entropy principles to Markov chains. We focus in particular on the convergence of such estimates in order to explain how our approach makes possible the estimation of transition ...
Gregor Chliamovitch   +2 more
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska   +13 more
wiley   +1 more source

A stochastic production frontier model with a translog specification using the generalized maximum entropy estimator [PDF]

open access: yes
In this paper, an empirical application of the generalized maximum entropy estimator in a stochastic production frontier model with a translog specification is discussed to investigate technical efficiency in a wine region of Portugal.
Elvira Silva, Pedro Macedo
core  

Maximum Entropy, Parallel Computations and Lotteries

open access: yes, 1998
By picking unpopular sets of numbers in a lottery, it is possible to increase one’s expected winnings. We have used the Maximum Entropy method to estimate the probability of each of the 14 million tickets being chosen by players in the UK National ...
Daniell, G.J., Nicole, D.A., Cox, S.J.
core   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

open access: yesMolecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura   +19 more
wiley   +1 more source

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