Results 51 to 60 of about 8,090,563 (284)
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
Entropy production from maximum entropy principle: A unifying approach
Physical Review EEntropy production is the crucial quantity characterizing irreversible phenomena and the second law of thermodynamics. Yet, a ubiquitous definition eludes consensus. Given that entropy production arises from incomplete access to information, in this Letter we use Jaynes' maximum entropy principle to establish a framework that brings together prominent ...
Adalberto D. Varizi, Pedro S. Correia
openaire +3 more sources
FEBS Letters, EarlyView.We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace +6 more
wiley +1 more source
Energy dissipation mechanism of a centrifugal pump with entropy generation theory
AIP Advances, 2021 From the numerical calculations of a common centrifugal pump, the energy loss characteristics have been investigated by applying entropy generation theory to examine the loss due to the direct, turbulence, and wall friction dissipation rates.
Ping Huang +5 more
doaj +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Gong-kuang zidonghua, 2016 According to characteristics of dynamic time sequence, complexity and uncertainty of coal mine production logistics system, security resources index system of coal mine production logistics system was determined that fully considered objective factors of
JIA Yibo +3 more
doaj +1 more source
Entropy, 2020 Understanding how nature drives entropy production offers novel insights regarding patient care. Whilst energy is always preserved and energy gradients irreversibly dissipate (thus producing entropy), increasing evidence suggests that they do so in the ...
Andrew J. E. Seely
doaj +1 more source
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
A radiative–convective model computing precipitation with the maximum entropy production hypothesis [PDF]
Geoscientific Model DevelopmentAll climate models use parameterizations and tuning in order to be accurate. The different parameterizations and tuning processes are the primary source of difference between models.
Q. Pikeroen, D. Paillard, K. Watrin
doaj +1 more source