Results 101 to 110 of about 1,124,505 (266)
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
The maximum flow in dynamic networks [PDF]
Computer Science Journal of Moldova, 2005 The dynamic maximum flow problem that generalizes the static maximum flow problem is formulated and studied. We consider the problem on a network with capacities depending on time, fixed transit times on the arcs, and a given time horizon.
Maria A. Fonoberova, Dmitrii D. Lozovanu
doaj
A maximum flow-based network approach for identification of stable noncoding biomarkers associated with the multigenic neurological condition, autism. [PDF]
BioData Min, 2021 Varma M +7 more
europepmc +1 more source
Molecular Oncology, EarlyView.In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera +11 more
wiley +1 more source
The Maximum Flow and Minimum Cost–Maximum Flow Problems: Computing and Applications
Asian Journal of Probability and Statistics, 2020 The maximum flow and minimum cost-maximum flow problems are both concerned with determining flows through a network between a source and a destination. Both these problems can be formulated as linear programming problems. When given information about a network (network flow diagram, capacities, costs), computing enables one to arrive at a solution to ...
openaire +2 more sources
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
MoleculesThe accumulation of metallic micro- and nanoparticles in the human hippocampus is increasingly linked to neurotoxic processes and neurodegenerative disorders.
Ján Pánik +6 more
doaj +1 more source
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
Assessing the design maximum discharges values in the lower pool of hydroelectric power plants
Водное хозяйство России: проблемы, технологии, управлениеOne of the important tasks of engineering hydrology and river runoff regulation, the solution of which is not fully regulated by current regulatory and methodological documents, is the determination of the design maximum discharges in the lower pools of
Mikhail V. Bolgov
doaj +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source