Results 121 to 130 of about 2,034,768 (362)
Molecular Oncology, EarlyView.There is an unmet need in metastatic breast cancer patients to monitor therapy response in real time. In this study, we show how a noninvasive and affordable strategy based on sequencing of plasma samples with longitudinal tracking of tumour fraction paired with a statistical model provides valuable information on treatment response in advance of the ...
Emma J. Beddowes +20 more
wiley +1 more source
Molecular Oncology, EarlyView.Loss of the frequently mutated chromatin remodeler ARID1A, a subunit of the SWI/SNF cBAF complex, results in less open chromatin, alternative splicing, and the failure to stop cells from progressing through the cell cycle after DNA damage in bladder (cancer) cells. Created in BioRender. Epigenetic regulators, such as the SWI/SNF complex, with important
Rebecca M. Schlösser +11 more
wiley +1 more source
Estimation of servo-system parameters using maximum likelihood method
Vojnotehnički Glasnik, 1998 The problem of estimation of servo system parameters that cannot be measured is solved. Unknown parameters are estimated using system response measurements. A special discrete, recursive and iterative form of maximum likelihood method is presented.
Nenad Dodić
doaj +1 more source
Molecular Oncology, EarlyView.Dual targeting of AKT and mTOR using MK2206 and RAD001 reduces tumor burden in an intracardiac colon cancer circulating tumor cell xenotransplantation model. Analysis of AKT isoform‐specific knockdowns in CTC‐MCC‐41 reveals differentially regulated proteins and phospho‐proteins by liquid chromatography coupled mass spectrometry. Circulating tumor cells
Daniel J. Smit +19 more
wiley +1 more source
Bayesian Inference from Composite Likelihoods, with an Application to Spatial Extremes [PDF]
arXiv, 2009 Composite likelihoods are increasingly used in applications where the full likelihood is analytically unknown or computationally prohibitive. Although the maximum composite likelihood estimator has frequentist properties akin to those of the usual maximum likelihood estimator, Bayesian inference based on composite likelihoods has yet to be explored. In
arxiv
Maximum-Likelihood Estimation of Parameters Subject to Restraints [PDF]
, 1958 J. Aitchison, S. D. Silvey
openalex +1 more source
Determination of ADP/ATP translocase isoform ratios in malignancy and cellular senescence
Molecular Oncology, EarlyView.The individual functions of three isoforms exchanging ADP and ATP (ADP/ATP translocases; ANTs) on the mitochondrial membrane remain unclear. We developed a method for quantitatively differentiating highly similar human ANT1, ANT2, and ANT3 using parallel reaction monitoring. This method allowed us to assess changes in translocase levels during cellular
Zuzana Liblova +18 more
wiley +1 more source
Analyticity, Convergence and Convergence Rate of Recursive Maximum Likelihood Estimation in Hidden Markov Models [PDF]
arXiv, 2009 This paper considers the asymptotic properties of the recursive maximum likelihood estimation in hidden Markov models. The paper is focused on the asymptotic behavior of the log-likelihood function and on the point-convergence and convergence rate of the recursive maximum likelihood estimator.
arxiv
Approximate selective inference via maximum likelihood
, 2020 This article considers a conditional approach to selective inference via approximate maximum likelihood for data described by Gaussian models. There are two important considerations in adopting a post-selection inferential perspective.
Panigrahi, Snigdha, Taylor, Jonathan
core