Results 61 to 70 of about 3,271,081 (257)
Consistency and asymptotic normality of the maximum likelihood estimator in a zero-inflated generalized Poisson regression [PDF]
, 2005 Poisson regression models for count variables have been utilized in many applications. However, in many problems overdispersion and zero-inflation occur.
Min, Aleksey, Czado, Claudia
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Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
FEBS Letters, EarlyView.Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas +4 more
wiley +1 more source
Calculation of Multivariate Normal Probabilities by Simulation, with Applications to Maximum Simulated Likelihood Estimation [PDF]
We discuss methods for calculating multivariate normal probabilities by simulation and two new Stata programs for this purpose: mvdraws for deriving draws from the standard uniform density using either Halton or pseudo-random sequences, and an egen ...
Lorenzo Cappellari, Stephen P. Jenkins
core
R.A. Fisher and the making of maximum likelihood 1912-1922
, 1997 In 1922 R. A. Fisher introduced the method of maximum likelihood. He first presented the numerical procedure in 1912. This paper considers Fisher's changing justifications for the method, the concepts he developed around it (including likelihood ...
Aldrich, J., John Aldrich, Aldrich, John
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Maximum Likelihood Estimation in the Fractional Vasicek Model
Lithuanian Journal of Statistics, 2017 We consider the fractional Vasicek model of the form dXt = (α-βXt)dt +γdBHt , driven by fractional Brownian motion BH with Hurst parameter H ∈ (1/2,1).
Stanislav Lohvinenko +1 more
doaj +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Maximum Likelihood Estimation of Latent Affine Processes [PDF]
This article develops a direct filtration-based maximum likelihood methodology for estimating the parameters and realizations of latent affine processes.
David S. Bates
core
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
Maximum Likelihood Decoder for Variable Length Codes
Sir Syed University Research Journal of Engineering and Technology, 2012 Variable Length Codes (VLC) are used to transfer same amount of digital information in relatively short period of time. In variable length coding, the characters with higher probability of occurrence are assigned shorter bits sequence and the characters
Syed Misbahuddin, Mohammed Talal Simsim
doaj