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A Bivariate Discrete Lindley Distribution and Applications [PDF]

المجلة العلمية للدراسات والبحوث المالية والتجارية
In this paper a bivariate discrete Lindley distribution has been derived from a discrete Lindely distribution using Farlie-Gumbel-Morgenstern copula. Some properties of this distribution such as probability generating function, conditional distributions,
Yasser Amer, Dina Abdelhady, Rania Shalabi   +2 more
doaj   +1 more source

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source

Calculation of Multivariate Normal Probabilities by Simulation, with Applications to Maximum Simulated Likelihood Estimation [PDF]

We discuss methods for calculating multivariate normal probabilities by simulation and two new Stata programs for this purpose: mvdraws for deriving draws from the standard uniform density using either Halton or pseudo-random sequences, and an egen ...
Lorenzo Cappellari, Stephen P. Jenkins
core  

Properties and Inference for a New Class of Generalized Rayleigh Distributions with an Application

Open Mathematics, 2019
In the present paper, we introduce a new form of generalized Rayleigh distribution called the Alpha Power generalized Rayleigh (APGR) distribution by following the idea of extension of the distribution families with the Alpha Power transformation.
Biçer Hayrinisa Demirci
doaj   +1 more source

Membrane composition and thermodynamic identity as boundaries of life for synthetic cell research

FEBS Letters, EarlyView.
What makes a cell a cell? The boundary of a living cell is not just a wall. Read as a Markov blanket, the membrane separates internal from external states, generating identity and non‐equilibrium order. Can this identity be rebuilt from scratch in a synthetic cell?
Caterina Presutti, Bert Poolman
wiley   +1 more source

Globally optimal parameter estimates for nonlinear diffusions [PDF]

, 2010
This paper studies an approximation method for the log-likelihood function of a nonlinear diffusion process using the bridge of the diffusion. The main result (Theorem 1) shows that this approximation converges uniformly to the unknown likelihood ...
Mijatović, Aleksandar, Schneider, P, Schneider, Paul, Mijatovic, A   +3 more
core   +1 more source

Least squares fitting the three-parameter inverse Weibull density [PDF]

, 2010
The inverse Weibull model was developed by Erto [10]. In practice, the unknown parameters of the appropriate inverse Weibull density are not known and must be estimated from a random sample.
Marušić, Miljenko, Darija Marković, Dragan Jukić, Miljenko Marušić, Marković, Darija, Jukić, Dragan   +5 more
core   +1 more source

Frequency Diversity Array for DOA Estimation [PDF]

Mehran University Research Journal of Engineering and Technology, 2017
The localization of targets has been presented in this article. DOA (Direction of Arrival) is an important parameter to be determined by radar. The MLE (Maximum Likelihood Estimator) has been widely used to accurately and efficiently estimate the DOAs ...
NAUMAN ANWAR BAIG, MOHAMMAD BILAL MALIK, MUHAMMAD ZEESHAN   +2 more
doaj  

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

Consistency and asymptotic normality of the maximum likelihood estimator in a zero-inflated generalized Poisson regression [PDF]

, 2005
Poisson regression models for count variables have been utilized in many applications. However, in many problems overdispersion and zero-inflation occur.
Min, Aleksey, Czado, Claudia
core   +1 more source