Results 91 to 100 of about 4,588,040 (299)

LogConcDEAD: An R Package for Maximum Likelihood Estimation of a Multivariate Log-Concave Density [PDF]

In this article we introduce the R package LogConcDEAD (Log-concave density estimation in arbitrary dimensions). Its main function is to compute the nonparametric maximum likelihood estimator of a log-concave density.
Madeleine Cule, Richard Samworth, Robert B. Gramacy   +2 more
core  

Predictive and prognostic biomarkers of Bacillus Calmette‐Guérin therapy failure in bladder cancer patients: A systematic review

Molecular Oncology, EarlyView.
High‐risk bladder cancer is typically treated with Bacillus Calmette‐Guérin (BCG), but 30–40% of patients relapse. No FDA‐ or CE‐approved biomarkers currently predict or prognosticate BCG failure. We systematically reviewed the literature and identified 72 eligible studies, revealing several promising biomarkers associated with BCG treatment response ...
Rui Ribeiro‐Pereira, Ana Teixeira‐Marques, Rui Freitas, João A Carvalho, Sara Monteiro‐Reis, Giorgio I. Russo, Rui Henrique, Carmen Jerónimo   +7 more
wiley   +1 more source

PINT: Maximum-likelihood Estimation of Pulsar Timing Noise Parameters

The Astrophysical Journal
PINT is a pure-Python framework for high-precision pulsar timing developed on top of widely used and well-tested Python libraries, supporting both interactive and programmatic data analysis workflows. We present a new frequentist framework within PINT to
Abhimanyu Susobhanan, David L. Kaplan, Anne M. Archibald, Jing Luo, Paul S. Ray, Timothy T. Pennucci, Scott M. Ransom, Gabriella Agazie, William Fiore, Bjorn Larsen, Patrick O’Neill, Rutger van Haasteren, Akash Anumarlapudi, Matteo Bachetti, Deven Bhakta, Chloe A. Champagne, H. Thankful Cromartie, Paul B. Demorest, Ross J. Jennings, Matthew Kerr, Sasha Levina, Alexander McEwen, Brent J. Shapiro-Albert, Joseph K. Swiggum   +23 more
doaj   +1 more source

Bias-Corrected Maximum Likelihood Estimation for the Process Performance Index using Inverse Gaussian Distribution

, 2023
An analytical bias-corrected maximum likelihood estimation procedure and a bootstrap bias-corrected maximum likelihood estimation procedure are proposed for the inverse Gaussian distribution (IGD) to obtain more reliable maximum likelihood estimates ...
Tsai, Tzong-Ru;Xin, H;Fan, Ya-Yen;Lio, YL
core  

Unique circulating miRNAome signatures captured with distinct molecular states in Lynch syndrome and sporadic colorectal cancer

Molecular Oncology, EarlyView.
Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso, Md Shohel Ul Islam, Rosa M Xicola, Raj Ramesar, Xavier Llor, Sinclair Steele   +5 more
wiley   +1 more source

Maximum likelihood distance estimation algorithm for multi-carrier radar system

The Journal of Engineering, 2019
In this study, a maximum likelihood distance estimation algorithm is proposed for a multi-carrier radar system to estimate the time delay of non-integer sampling intervals. Particularly, the equivalent relationship between time domain delay and frequency
Yue Chen, Dazhuan Xu, Hao Luo, Shengkai Xu, Yueshuai Chen   +4 more
doaj   +1 more source

Simulated Maximum Likelihood Estimation of the Linear Expenditure System with Binding Non-Negativity Constraints [PDF]

This paper discusses issues on the estimation of consumer demand equations subject to binding non-negative constraints. We propose computationally feasible specifications and a simulated maximum likelihood (SML) method for demand systems. Our study shows
Lung-fei Lee, Chihwa Kao, Mark M. Pitt
core  

Characterization of therapeutic antibodies targeting lymphatic and vascular resistance factor for the treatment of hypervascularized and highly metastatic cancers

Molecular Oncology, EarlyView.
LVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
Marion David, Arthur Karaulic, Audrey Bennetot, Clémence Fournier, Quentin Odet, Arthur Gouraud, Isabelle Bourget, Cédric Gaggioli, Sandy Giuliano, Frédéric Luciano, Olivier Léger, Zaki Sellam, Gilles Pagès   +12 more
wiley   +1 more source

Semi-blind joint maximum likelihood channel estimation and data detection for MIMO systems

, 2008
Semi-blind joint maximum likelihood (ML) channel estimation and data detection is proposed for multiple-input multiple-output (MIMO) systems. The joint ML optimization over channel and data is decomposed into an iterative two-level optimization loop.
Chen, Sheng, Abuthinien, M., Hanzo, Lajos   +2 more
core   +1 more source

Optimization of seminal extracellular vesicle isolation protocols for cancer biomarker analysis using proteomic profiling

Molecular Oncology, EarlyView.
This paper shows that size‐exclusion chromatography and sequential centrifugation applied to seminal plasma enrich for different populations of extracellular vesicles. This may significantly affect the detection and analysis of extracellular vesicle‐associated cancer biomarkers.
Elen Telumyan, Beatriz Martín‐Gracia, Eva Bassols‐Citores, Krizia Sagini, Maria K. Andersen, Tuula A. Nyman, May‐Britt Tessem, Morten B. Rye, Alicia Llorente   +8 more
wiley   +1 more source