Results 71 to 80 of about 1,248,247 (319)

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

Maximum Likelihood Estimation of Functionals of Discrete Distributions

, 2017
We consider the problem of estimating functionals of discrete distributions, and focus on tight nonasymptotic analysis of the worst case squared error risk of widely used estimators.
Han, Yanjun, Jiao, Jiantao, Venkat, Kartik, Weissman, Tsachy   +3 more
core   +1 more source

Asymptotic results for maximum likelihood estimators in joint analysis of repeated measurements and survival time [PDF]

, 2005
Maximum likelihood estimation has been extensively used in the joint analysis of repeated measurements and survival time. However, there is a lack of theoretical justification of the asymptotic properties for the maximum likelihood estimators. This paper
Cai, Jianwen, Zeng, Donglin
core   +4 more sources

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

Molecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris, Vasiliki Siozopoulou, Léon C van Kempen, Anne Sieben, Ella Roelant, Stig Hellemans, Elyne Backx, Laure Sorber, Koen De Winne, Senada Koljenović, Karen Zwaenepoel   +10 more
wiley   +1 more source

Semidefinite Programming for Approximate Maximum Likelihood Sinusoidal Parameter Estimation

EURASIP Journal on Advances in Signal Processing, 2009
We study the convex optimization approach for parameter estimation of several sinusoidal models, namely, single complex/real tone, multiple complex sinusoids, and single two-dimensional complex tone, in the presence of additive Gaussian noise.
Kenneth W. K. Lui, H. C. So
doaj   +1 more source

BlinkML: Efficient Maximum Likelihood Estimation with Probabilistic Guarantees

, 2018
The rising volume of datasets has made training machine learning (ML) models a major computational cost in the enterprise. Given the iterative nature of model and parameter tuning, many analysts use a small sample of their entire data during their ...
Anderson M. R., Bardenet R., Bergstra J. S., Bottou L., Crankshaw D., Derezinski M., Drineas P., Duchi J., Feurer M., Gittens A., Le Q. V., Lin C.-J., Lucic M., Maclaurin D., Martens J., Mozafari B., Musco C., Ogawa K., Pedregosa F., R, Recht B., Salakhutdinov R., Tieleman T., Tipping M. E., Weimer M., Xing E., Yang A. Y.   +26 more
core   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

Maximum likelihood estimation in the non-ergodic fractional Vasicek model

Modern Stochastics: Theory and Applications, 2019
We investigate the fractional Vasicek model described by the stochastic differential equation $d{X_{t}}=(\alpha -\beta {X_{t}})\hspace{0.1667em}dt+\gamma \hspace{0.1667em}d{B_{t}^{H}}$, ${X_{0}}={x_{0}}$, driven by the fractional Brownian motion ${B^{H}}$
Stanislav Lohvinenko, Kostiantyn Ralchenko   +1 more
doaj   +1 more source

High Dynamic GPS Tracking Loop Based on Fast Maximum Likelihood Estimation [PDF]

Jisuanji gongcheng, 2016
In high dynamic environment,the Global Positioning System(GPS) software receiver has low tracking accuracy and is prone to loss of lock.To solve these problems,a high accuracy and fast tracking method based on Maximum Likelihood Estimation(MLE) is ...
YI Qingming,LUO Chong,SHI Min
doaj   +1 more source