Results 161 to 170 of about 1,248,247 (319)

Value of MRI Outcomes for Preventive and Early‐Stage Trials in Spinocerebellar Ataxias 1 and 3

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To examine the value of MRI outcomes as endpoints for preventive and early‐stage trials of two polyglutamine spinocerebellar ataxias (SCAs). Methods A cohort of 100 participants (23 SCA1, 63 SCA3, median Scale for the Assessment and Rating of Ataxia (SARA) score = 5, 42% preataxic, and 14 gene‐negative controls) was scanned at 3T up ...
Thiago J. R. Rezende, Emilien Petit, Young Woo Park, Sophie Tezenas du Montcel, James M. Joers, Jonathan M. DuBois, H. Moore Arnold, Michal Povazan, Ipek Özdemir, Guita Banan, Romain Valabregue, Philipp Ehses, Jennifer Faber, Chiadi U. Onyike, Peter B. Barker, Jeremy D. Schmahmann, Eva‐Maria Ratai, Sub H. Subramony, Thomas H. Mareci, Khalaf O. Bushara, Henry Paulson, Thomas Klockgether, Alexandra Durr, Tetsuo Ashizawa, Christophe Lenglet, Gülin Öz, READISCA Investigators   +26 more
wiley   +1 more source

Reducing computational demands of restricted maximum likelihood estimation with genomic relationship matrices. [PDF]

Genet Sel Evol, 2023
Meyer K.
europepmc   +1 more source

Complementarity of Long‐Reads and Optical Mapping in Parkinson's Disease for Structural Variants

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Long‐read sequencing and optical genome mapping technologies have the ability to detect large and complex structural variants. This has led to the discovery of novel pathogenic variants in neurodegenerative movement disorders. Thus, we aimed to systematically compare the SV detection capabilities of OGM and ONT in Parkinson's disease.
André Fienemann, Theresa Lüth, Susen Schaake, Carolin Gabbert, Marius Möller, Hauke Busch, Katja Lohmann, Jonas A. Gustafson, Danny E. Miller, Kensuke Daida, Manabu Funayama, Nobutaka Hattori, Samia Ben Sassi, Faycel Hentati, Matthew J. Farrer, Kristian K. Ullrich, Christine Klein, Joanne Trinh   +17 more
wiley   +1 more source

Predicting COVID-19 Infections in Eswatini Using the Maximum Likelihood Estimation Method [PDF]

Int J Environ Res Public Health, 2022
Dlamini SN, Dlamini WM, Socé Fall I.
europepmc   +2 more sources

Targeted Maximum Likelihood Estimation for Causal Inference in Observational Studies

American Journal of Epidemiology, 2017
Megan S. Schuler, Sherri Rose
semanticscholar   +1 more source

"Within-Trial" Prognostic Score Adjustment Is Targeted Maximum Likelihood Estimation. [PDF]

Pharm Stat
Højbjerre-Frandsen E, Schuler A.
europepmc   +1 more source

Maximum Likelihood Estimation for Shape-restricted Single-index Hazard Models. [PDF]

J Data Sci, 2023
Qin J, Sun Y, Yuan A, Huang CY.
europepmc   +1 more source

A Prospective Study of Individuals at Risk of Multiple Sclerosis Informs the Design of Primary Prevention Studies

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective In multiple sclerosis, the optimal time for deploying a therapeutic intervention is before the central nervous system is damaged; given the success of trials treating the earliest stage of MS, the radiologically isolated syndrome, developing primary prevention strategies is an important next challenge.
Amy W. Laitinen, Ceren Tozlu, Tina Roostaei, Fatoumata Diallo, Kaho Onomichi, Jiyeon Son, Zongqi Xia, Philip L. De Jager   +7 more
wiley   +1 more source

Prenatal paracetamol exposure and wheezing in infancy: a targeted maximum likelihood estimation application. [PDF]

BMJ Open Respir Res
Moccia C, Zugna D, Popovic M, Moirano G, Pizzi C, Migliore E, Fariselli P, Sanavia T, Rusconi F, Nybo Andersen AM, Richiardi L, Maule M.   +11 more
europepmc   +1 more source

The identification of mediating effects using genome-based restricted maximum likelihood estimation. [PDF]

PLoS Genet, 2023
Rietveld CA, de Vlaming R, Slob EAW.
europepmc   +1 more source