Results 51 to 60 of about 373,692 (326)

On estimation of the diagonal elements of a sparse precision matrix

open access: yes, 2016
In this paper, we present several estimators of the diagonal elements of the inverse of the covariance matrix, called precision matrix, of a sample of iid random vectors. The focus is on high dimensional vectors having a sparse precision matrix.
Balmand, Samuel, Dalalyan, Arnak S.
core   +1 more source

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

open access: yesFEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi   +5 more
wiley   +1 more source

Moderate deviations of maximum likelihood estimators under alternatives [PDF]

open access: yes, 2000
Since statistical models are simplifications of reality, it is important in estimation theory to study the behavior of estimators also under distributions (slightly) different from the proposed model.
Inglot, T., Kallenberg, W.C.M.
core   +1 more source

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

open access: yesFEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo   +2 more
wiley   +1 more source

Closed-form estimators for the inverse Nakagami distribution

open access: yesAnais da Academia Brasileira de Ciências
The inverse Nakagami distribution due to Louzada et al. (2018) does not have closed-form maximum likelihood estimators. Closed-form estimators by adapting the method of moments are proposed in this note.
VICTOR NAWA, SARALEES NADARAJAH
doaj   +1 more source

An Improvement in Maximum Likelihood Estimation of the Gompertz Distribution Parameters

open access: yesJournal of Statistical Theory and Applications (JSTA), 2023
In this study, we will look at estimating the parameters of the Gompertz distribution. We know that the maximum likelihood technique is the most often used method in the literature for parameter estimation.
Ali A. Al-Shomrani
doaj   +1 more source

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

open access: yesFEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Non-Parametric Maximum Likelihood Density Estimation and Simulation-Based Minimum Distance Estimators [PDF]

open access: yes, 2010
Indirect inference estimators (i.e., simulation-based minimum distance estimators) in a parametric model that are based on auxiliary non-parametric maximum likelihood density estimators are shown to be asymptotically normal.
Gach, Florian, Pötscher, Benedikt M.
core   +2 more sources

Fixed-domain asymptotic properties of tapered maximum likelihood estimators

open access: yes, 2009
When the spatial sample size is extremely large, which occurs in many environmental and ecological studies, operations on the large covariance matrix are a numerical challenge.
Du, Juan, Mandrekar, V. S., Zhang, Hao
core   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

open access: yesFEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva   +5 more
wiley   +1 more source

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