Results 91 to 100 of about 4,507,842 (291)
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Variants in SLC6A1, encoding the GABA transporter 1 (GAT‐1), cause epilepsy, autism spectrum disorder, and developmental delay via loss of GABA uptake, impaired trafficking, and ER retention. We previously found that 4‐Phenylbutyrate (PBA), an FDA‐approved drug, restores GABA uptake and reduces seizures in SLC6A1‐related disorders ...
Melissa B. DeLeeuw +5 more
wiley +1 more source
Characterizing Cutaneous α‐Synuclein Deposition and Seeding Activity in Parkinson's Disease Subtypes
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Cutaneous phosphorylated α‐synuclein (p‐syn) and α‐synuclein seeding activity are promising biomarkers for Parkinson's disease (PD), but their clinical value remains uncertain due to disease heterogeneity. This study evaluates these two biomarkers in PD patients to inform phenotype‐specific diagnosis and disease severity assessment ...
Yuting Jin +8 more
wiley +1 more source
A simple approach to maximum intractable likelihood estimation [PDF]
, 2013 Approximate Bayesian Computation (ABC) can be viewed as an analytic approximation of an intractable likelihood coupled with an elementary simulation step.
Rubio, Francisco J., Johansen, Adam M.
core +1 more source
IEEE Access, 2019 Maximum power point tracking (MPPT) is essential in Photovoltaic (PV) systems, which has drawn significant research effort in the past. The operation is to adjust the power interfaces so that the operating characteristics of the consumption and the PV ...
Xingshuo Li +3 more
doaj +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Treatment of disorders of consciousness (DoC) remains a major clinical challenge, and noninvasive, targeted modulation of deep brain structures has emerged as a promising therapeutic strategy. We aimed to evaluate the feasibility/safety and preliminary effects of thalamic temporal interference stimulation (TIS) targeting centromedian‐
Gengyao Hu +7 more
wiley +1 more source
Two maximum principles for a nonlinear fourth order equation from thin plate theory
Electronic Journal of Qualitative Theory of Differential Equations, 2014 We develop two maximum principles for a nonlinear equation of fourth order that arises in thin plate theory. As a consequence, we obtain uniqueness results for the corresponding fourth order boundary value problem under Navier boundary conditions as ...
Cristian-Paul Danet
doaj +1 more source
Reserves, Injury Severity, and Outcomes in Traumatic Brain Injury: A CENTER‐TBI Observational Study
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Reserve refers to the brain's ability to maintain function after an injury and strongly relates to traumatic brain injury (TBI) outcomes. This study examined (1) whether associations between pre‐injury reserve proxies and outcomes differed across injury severity categories, and (2) whether the impact of injury severity varied across ...
Natascha Ekdahl +6 more
wiley +1 more source
Extended weak maximum principles for parabolic partial differential inequalities on unbounded domains [PDF]
, 2014 In this paper, we establish extended maximum principles for solutions to linear parabolic partial differential inequalities on unbounded domains, where the solutions satisfy a variety of growth/decay conditions on the unbounded domain.
Needham, D. J., Meyer, J. C.
core +1 more source
Anais da Academia Brasileira de Ciências, 2002 In this paper we generalize and extend to any Riemannian manifold maximum principles for Euclidean hypersurfaces with vanishing curvature functions obtained by Hounie-Leite.Neste trabalho nós generalizamos e estendemos para uma variedade Riemanniana ...
FRANCISCO X. FONTENELE, SÉRGIO L. SILVA
doaj +1 more source
The Association of Amyloid‐β and Tau With Synaptic Dysfunction in Alzheimer's Disease
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective To clarify the relative contributions of amyloid and tau to synaptic dysfunction in Alzheimer's disease (AD). Methods We included 109 cognitively unimpaired and impaired individuals from the Geneva Memory Center with available CSF synaptic biomarkers (neurogranin, SNAP‐25, GAP‐43). Participants were stratified according to amyloid (A)
Fausto Roveta +11 more
wiley +1 more source