Results 171 to 180 of about 6,253 (218)

Light‐Activatable Nitric Oxide Release via Intramolecular Electron Transfer for Tumor Pyroptosis Induction

Advanced Science, EarlyView.
This work proposes a novel strategy to fabricate unimolecular pyroptosis photoinitiators activated by deep‐red light at low light doses. It relies on a photosensitization mechanism to trigger nitric oxide (NO) release from benzisothiadiazole‐based N‐nitrosanilines without modification of nitro moieties, thereby boosting pyroptosis‐mediated ...
Chuangxin Zhang, Ruipeng Li, Yunxia Wang, Feng Liu, Liheng Feng   +4 more
wiley   +1 more source

Bioinspired nondissipative mechanical energy storage and release in hydrogels via hierarchical sequentially swollen stretched chains. [PDF]

Nat Commun
Savolainen H, Hosseiniyan N, Piedrahita-Bello M, Ikkala O.   +3 more
europepmc   +1 more source

Metabolic Imbalance Triggers Adaptive Remodeling to Accelerate Diploidization in Murine Haploid Embryonic Stem Cells

Advanced Science, EarlyView.
In this article, Shuai and colleagues demonstrate that metabolic remodeling drives self‐diploidization in murine haploid ESCs (haESCs). Mitochondrial dysfunction and imbalanced pyruvate metabolism underlie this process. Genome‐wide screening using haESCs identifies key mitochondrial quality‐control related genes, enabling a metabolism‐based medium that
Yi Fu, Wenhao Zhang, Yifan Zhang, Yu He, Yi Du, Yiding Zhao, Chunmeng Yao, Shengyi Sun, Xiaoyan Sheng, Qian Gao, Chao Tong, Ling Shuai   +11 more
wiley   +1 more source

Clinical insights on sialography in the era of modern imaging: A case report of 5 cases. [PDF]

Radiol Case Rep
Sambyal S, Prasad R G, Devi RR, Rana AK, Verma S.   +4 more
europepmc   +1 more source

mGluR5 in ECCCK to BLA Circuit Modulates Depressive‐Like Phenotypes through CCK Signaling

Advanced Science, EarlyView.
Dysregulation of mGluR5 and CCK signaling contributes to major depressive disorder, yet circuit‐level mechanisms remain unclear. Here, the ECCCK→BLA pathway is identified as a critical regulator of affective behavior. mGluR5 modulates synaptic function and CCK signaling within this circuit, controlling stress susceptibility and depressive‐like states ...
Muhammad Asim, Huajie Wang, Gao Qianqian, Abdul Waris, Jufang He   +4 more
wiley   +1 more source

Secretion of antifungal metabolites contributes to the antagonistic activity of <i>Talaromyces oaxaquensis</i>. [PDF]

Curr Res Microb Sci
Zárate-Ortiz AI, Villarruel-Ordaz JL, Sánchez-Espinosa AC, Carballo-Castañeda RA, Moreno-Ulloa A, Maldonado-Bonilla LD.   +5 more
europepmc   +1 more source

A C. elegans Model for Spinal Muscular Atrophy Reveals Neuron Specific Developmental and Degenerative Defects

Savaheli S, Gallotta I, Santonicola P, Cieri F, Berger S, Dargere D, Di Schiavi E, Dupuy D.   +7 more
europepmc   +1 more source

Importance of Genotype-Phenotype Correlation in the Population Screening of Familial Hypercholesterolemia. [PDF]

Cureus
Das T, Mondal S, Rawool AK, Tarafdar S, Ghosh A.   +4 more
europepmc   +1 more source

Purkinje Cell Dendritic Swellings: A Postmortem Study of Essential Tremor and Other Cerebellar Degenerative Disorders. [PDF]

Cerebellum
Louis ED, Kuo SH, Faust PL.
europepmc   +1 more source

Distribution of non-thyroid neck swellings and their clinicopathological correlation. [PDF]

J Family Med Prim Care
Chaturvedi HT, Patel B, Chaturvedi C, Damor PK, Patel V, Vasava R.   +5 more
europepmc   +1 more source