Results 141 to 150 of about 1,555,997 (313)

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Association between maximum temperature and PM_2.5 with pregnancy outcomes in Lima, Peru. [PDF]

Environ Epidemiol, 2021
Tapia VL, Vasquez-Apestegui BV, Alcantara-Zapata D, Vu B, Steenland K, Gonzales GF.   +5 more
europepmc   +1 more source

Historical and future maximum sea surface temperatures

Science Advances
Marine heat waves affect ocean ecosystems and are expected to become more frequent and intense. Earth system models’ ability to reproduce extreme ocean temperature statistics has not been tested quantitatively, making the reliability of their future projections of marine heat waves uncertain.
Cael, B. B., Burger, Friedrich A., Henson, Stephanie A., Britten, Gregory L., Frölicher, Thomas L.   +4 more
openaire   +3 more sources

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Analytical Model for the Channel Maximum Temperature in Ga₂O₃ MOSFETs. [PDF]

Nanoscale Res Lett, 2021
Jia X, Hu H, Han G, Liu Y, Hao Y.
europepmc   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Study of Heat Wave Using High‐Resolution Real Time Meso‐Scale Analysis Over India

Geophysical Research Letters
The applicability and accuracy of high‐resolution Real‐Time Meso‐scale Analysis (RTMA) system is assessed over India for the first time. The RTMA is a high‐spatial (2.5 km) and temporal resolution analysis system for near‐surface weather conditions.
Ch. Sridevi, Ashish Routray, M. V. S. Ramarao, Suryakanti Dutta, K. B. R. R. Hari Prasad, Edward Colón, Annette Gibbs, Manuel Pondeca, V. S. Prasad   +8 more
doaj   +1 more source

Investigating age and regional effects on the relation between the incidence of heat-related ambulance transport and daily maximum temperature or WBGT. [PDF]

Environ Health Prev Med, 2021
Ueno S, Hayano D, Noguchi E, Aruga T.
europepmc   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Effect modification by maximum temperature of the association between PM_2.5 and short-term cardiorespiratory mortality and emergency room visits in Lima, Peru, 2010-2016. [PDF]

J Expo Sci Environ Epidemiol, 2022
Steenland K, Vu B, Scovronick N.
europepmc   +1 more source