Results 121 to 130 of about 1,555,997 (313)

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Research and Structural Optimization of Lithium Battery Heat Dissipation Based on Leaf Vein Channels

Batteries
The operating temperature of lithium batteries directly affects their charge–discharge performance. This study is based on the LF50K prismatic power battery.
Haiyan Dai, Changyu Li, Jixiang Zhou
doaj   +1 more source

Reconstructed warm season temperatures for Nome, Seward Peninsula, Alaska [PDF]

, 2004
Understanding of past climate variability in the Bering Strait region and adjacent land areas is limited by a paucity of long instrumental and paleoclimatic records. Here we describe a reconstruction of May–August temperatures for Nome, Seward Peninsula,
Frank, D, Jacoby, G, Mashig, E., Frank, D., Mashig, E, Wilson, Rob, Jacoby, G., D'Arrigo, R, D'Arrigo, R.   +8 more
core   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Tree-ring stable carbon isotope-based June–September maximum temperature reconstruction since AD 1788, north-west Thailand

Tellus: Series B, Chemical and Physical Meteorology, 2018
The first study of tree-ring stable carbon isotopes in Thailand has demonstrated that stable carbon isotope in northwestern Thailand represents a promising proxy for the temperature reconstruction of core-monsoon periods.
Paramate Payomrat, Yu Liu, Nathsuda Pumijumnong, Qiang Li, Huiming Song   +4 more
doaj   +1 more source

Modelling of a stand alone photovoltaic system with dedicated hybrid battery energy storage system [PDF]

, 2012
Includes abstract.Includes bibliographical references.The purpose of this thesis project was to model and simulate a stand-alone photovoltaic (PV) plant that utilized the maximum power point tracking (MPPT) technique and included a hybrid battery energy ...
Vanden Eynde, Nicholas
core  

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

Future overheating risk in prisons in England and Wales using the UK climate projections

Frontiers in Climate
High temperatures, leading to overheating, impact the welfare of prisoners, staff and visitors in prisons in England and Wales. Quantifying current and future overheating risk can inform adaptation decision making and prioritisation of investment.
Michael Sanderson, Emma Dyer, Laura Dawkins, Rajat Gupta, Kia Trainor, Megan Hunt   +5 more
doaj   +1 more source

Contemporary Warming and Daily Values of Temperature (on the Example of Warsaw)

Miscellanea Geographica: Regional Studies on Development, 2004
This paper aims at presenting changes in everyday air temperature values, triggered by the contemporary warming process. The analysis has been based on the mean, maximum, and minimum daily temperature values measured in Warsaw between 1951 – 2003.
Kossowska-Cezak Urszula
doaj   +1 more source