Results 111 to 120 of about 3,912,221 (304)
Molecular Oncology, EarlyView.Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen +11 more
wiley +1 more source
Description of the warm core turbine facility recently installed at NASA Lewis Research Center [PDF]
The two net facilities were installed and operated at their design, or rated conditions. The important feature of both of these facilities is that the ratio of turbine inlet temperature to coolant temperature encountered in high temperature engines can ...
Moffitt, T. P. +2 more
core +1 more source
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
Comparison of temperature data from an engine investigation for film-cooled and non-film-cooled, panwise-finned vanes incorporating impingement cooling [PDF]
The experimental temperature characteristics of two spanwise-finned, impingement-cooled vanes, one with film cooling and one without film cooling, were investigated in a modified J-75 research turbojet engine.
Gauntner, D. J.
core +1 more source
, 2009 We present the results of numerical analysis of a model of normal zone propagation in coated conductors. The main emphasis is on the effects of increased contact resistance between the superconducting film and the stabilizer on the speed of normal zone ...
+11 more
core +1 more source
Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source
Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
A Machine Learning Method for Maximum Temperature Bias Correction in Complex Terrain
Gaoyuan qixiangTo enhance the prediction accuracy of the 2-meter maximum temperature in complex terrain areas， this study developed a gradient modeling approach based on the LightGBM （Light Gradient Boosting Machine， LGB） algorithm， applied to the Sichuan Basin and its
Qiuxue ZHOU +3 more
doaj +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Research and Structural Optimization of Lithium Battery Heat Dissipation Based on Leaf Vein Channels
BatteriesThe operating temperature of lithium batteries directly affects their charge–discharge performance. This study is based on the LF50K prismatic power battery.
Haiyan Dai, Changyu Li, Jixiang Zhou
doaj +1 more source