Results 91 to 100 of about 1,555,997 (313)
FEBS Letters, EarlyView.Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara +3 more
wiley +1 more source
AtmosphereEnsuring food security in Pakistan, particularly for rice production, is a critical challenge due to increasing population demands and the growing impact of climate change variability.
Muhammad Haroon Shah +5 more
doaj +1 more source
FEBS Letters, EarlyView.Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley +1 more source
Prediction of Climatic Variables using Statistical Downscaling Model (SDSM) in Future under Scenario A2 [PDF]
مدیریت بیابان, 2016 In recent decades, the increase of temperature has caused the disturbance of climatic balance of the earth and extensive climate changes which is called climate change. The aim of this study is to predict the climate changes using statistical downscaling
Ali Salajegheh +6 more
doaj +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Histogram of maximum temperature differences. [PDF]
, 2019 Histogram of maximum temperature differences ΔTmax at normal distribution and results of the normality test.
Krzysztof Dudek (4345051) +5 more
core +1 more source
FEBS Letters, EarlyView.The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi +6 more
wiley +1 more source
Composition calculation and cracking estimation of concrete at early ages
Инженерно-строительный журнал, 2018 Recently, variety of large-scale constructions from monolithic concrete structures have been built in different regions of Vietnam. The application fields of these structures are extensive including the marine construction, underground structures, the ...
Tang Vang Lam +3 more
doaj +1 more source
Effect of maximum temperature. [PDF]
, 2018 Effect of the maximum temperature on the risk of influenza A (H1N1) in Paraná State from April 5 to September 26 in 2009 (corresponding to epidemiological weeks 14 to 38).
Aline Araújo Nobre (759331) +4 more
core +1 more source
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source