Results 71 to 80 of about 3,900,760 (304)

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Prediction of Climatic Variables using Statistical Downscaling Model (SDSM) in Future under Scenario A2 [PDF]

مدیریت بیابان, 2016
In recent decades, the increase of temperature has caused the disturbance of climatic balance of the earth and extensive climate changes which is called climate change. The aim of this study is to predict the climate changes using statistical downscaling
Ali Salajegheh, Elham Rafiei Sardooei, Ali Reza Moghaddamnia, Arash Malekian, Shahab Araghinejad, Shahram Khalighi Sigaroodi, Ali Salehpourjam   +6 more
doaj   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

Composition calculation and cracking estimation of concrete at early ages

Инженерно-строительный журнал, 2018
Recently, variety of large-scale constructions from monolithic concrete structures have been built in different regions of Vietnam. The application fields of these structures are extensive including the marine construction, underground structures, the ...
Tang Vang Lam, Trong-Chuc Nguyen, Boris Bulgakov, Pham Anh   +3 more
doaj   +1 more source

Experimental investigation of the origin of the cross-over temperature in the cuprates [PDF]

, 2008
We investigate the cross-over temperature T* as a function of doping in (Ca_{x}La_{1-x})(Ba_{1.75-x}La_{0.25+x})Cu_3O_{y}, where the maximum Tc (Tc^max) varies continuously by 30% between families (x) with minimal structural changes.
Amit Keren, D. C. Johnston, J. Rossat-Mignod, J. Zaanen, L. B. Ioffe, L. P. Regnault, P. W. Selwood, Yuval Lubashevsky   +7 more
core   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Assemblage and diversity analysis of butterfly species in relation to climatic conditions in some tropical habitats: optimization through artificial neural network model

Journal of Ecology and Environment
Background: Biodiversity serves as the foundation for ecosystems and the functional roles of species that supply services to human well-being. The functional roles of species in a region can be assessed by estimating biological diversity.
Subha Shankar Mukherjee, Asif Hossain
doaj   +1 more source

Historical and future maximum sea surface temperatures

Science Advances
Marine heat waves affect ocean ecosystems and are expected to become more frequent and intense. Earth system models’ ability to reproduce extreme ocean temperature statistics has not been tested quantitatively, making the reliability of their future projections of marine heat waves uncertain.
Cael, B. B., Burger, Friedrich A., Henson, Stephanie A., Britten, Gregory L., Frölicher, Thomas L.   +4 more
openaire   +4 more sources

Maximum dew-point temperature in India

MAUSAM, 1951
The moisture content of an air mass over a station depends upon the dew-point at the station and the higher the dew-point, the higer is the moisture content of the air mass. A knowledge of the maximum possible dew-point at a place is thus necessary for estimating the maximum possible precipitation.
S.K. Paramanik, P.S. Hariharan
openaire   +2 more sources