Results 81 to 90 of about 3,900,760 (304)

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Estimating the maximum rise in temperature according to climate models using abstract interpretation [PDF]

, 2020
Current climate models are complex computer programs that are typically iterated time-step by time-step to predict the next set of values of the climate-related variables.
Revesz, Peter, Woodward, Robert J.
core   +1 more source

Statistical modeling of maximum temperature in Guinea

Anais da Academia Brasileira de Ciências
A statistical analysis of maximum temperature from twelve weather stations in parts of Guinea is provided. Using maximum likelihood estimation, maximum temperature data was fitted by the Generalized Extreme Value distribution. Data from all of the twelve stations were adequately fit by the Generalized Extreme Value distribution.
MALICK KEBE, SARALEES NADARAJAH
openaire   +3 more sources

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Variations in Maximum and Minimum Temperature in Mount Qomolangma during 1971–2020

Atmosphere
Based on the daily maximum and minimum temperature observational data during 1971–2020, the variabilities of the maximum and minimum temperature of Mount Qomolangma are analyzed.
Shunjiu Wang
doaj   +1 more source

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source

Ratchet limits for a crack in a welded pipe subjected to a cyclic temperature load an a constant mechanical load [PDF]

, 2011
This paper presents the ratchet limit analysis of a pipe with a symmetric crack in a mismatched weld by using the extended Linear Matching Method (LMM). Two loading conditions are considered: i) a cyclic temperature load and a constant internal pressure;
Chen, Haofeng, Chen, Weihang, Li, Tianbai, Ure, James Michael   +3 more
core  

Dynamics of cold pulses induced by super-sonic molecular beam injection in the EAST tokamak

, 2018
Evolution of electron temperature, electron density and its fluctuation with high spatial and temporal resolutions are presented for the cold pulse propagation induced by super-sonic molecular beam injection (SMBI) in ohmic plasmas in the EAST tokamak ...
Cao, Bin, Liu, Ahdi, Liu, Xiang, Liu, Yong, Naulin, Volker, Shi, Yuejiang, Zhang, Shoubiao, Zhang, Tao, Zhao, Hailin, Zhou, Chu, Zhou, Tianfu, Zou, Xiaolan   +11 more
core   +1 more source

April Mean Daily Maximum Temperatures

, 2010
The map shows the mean daily maximum temperatures for April. Below-freezing maximum temperatures in April are restricted to northern Canada and the extreme northern portions of Ontario and Quebec adjacent to Hudson Bay. Lengthening days and strengthening sunshine bring about a moderation in temperature in all parts of the country.
openaire   +1 more source