Results 141 to 150 of about 56,014 (312)
A novel model of early experiences involving neonatal learning of a T‐maze using maternal contact as a reward or its denial as an event of mild emotional adversity [PDF]
, 2014 Antonios Stamatakis +4 more
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LRRK2 as a Potential Disease‐Modifying Target in Sporadic Parkinson's Disease
Movement Disorders, EarlyView.Abstract A growing understanding of the role that leucine‐rich repeat kinase 2 (LRRK2) plays in Parkinson's disease (PD) supports continued focus on this enzyme as a therapeutic target for PD. Accumulating evidence suggests that there are phenotypic, neuropathologic, and biological similarities between sporadic PD (sPD) and familial forms in which ...
Anthony E. Lang +12 more
wiley +1 more source
TULP4, a novel E3 ligase gene, participates in neuronal migration as a candidate in schizophrenia
CNS Neuroscience &Therapeutics, EarlyView., 2023 Mutations identified from four SCZ pedigrees resulted in decreased TULP4 expression. Tulp4 knockdown caused delayed neuron migration in embryonic mice, and impaired cognition and prepulse inhibition in adult mice. These phenotypes may be related to TULP4 through its involvement in the formation of a novel E3 ubiquitin ligases.
Yan Bi +19 more
wiley +1 more source
Movement Disorders, EarlyView.Abstract Background Transsynaptic α‐synuclein propagation plays a crucial role in the progression of Lewy body disease. We previously demonstrated that an α‐amino‐3‐hydroxy‐5‐methyl‐4‐isoxazolepropionic acid receptor antagonist, perampanel, blocks neuronal uptake of α‐synuclein preformed fibrils (PFFs) in an activity‐dependent manner.
Jun Ueda +9 more
wiley +1 more source
Magnetic Resonance in Medicine, EarlyView.ABSTRACT Purpose Functional MRI (fMRI) in awake rodents presents countless valuable opportunities for researchers to probe questions that may not be accessible through anesthetized models, such as voluntary locomotion. The commonly used echo planar imaging (EPI) sequence is highly sensitive to motion that occurs even outside of the imaging plane ...
Lauren Daley +3 more
wiley +1 more source
مجله دانشگاه علوم پزشکی بیرجندBackground and Aims: Chronic immobilization is a type of stress that causes behavioral disorders such as anxiety and memory deficits by inducing oxidative stress and inflammation and changing the level of neurotransmitters in the brain. In this research,
Yaghoob Bigdeli, Masoumeh Asle-Rousta
doaj
People and Nature, EarlyView.Abstract Amid increasing urbanisation and biodiversity decline, ‘effective stewardship’ of urban green space (UGS) is a complex but critical nature‐based solution for long‐term environmental, social and economic gain. Combining stewardship and sense‐of‐place frameworks with European nature‐based solutions guidance, we investigate which social and ...
Fay Kahane +2 more
wiley +1 more source
Spatial Learning in Japanese Eels Using Extra- and Intra-Maze Cues
, 2020 Shigeru Watanabe
openalex +1 more source