Results 131 to 140 of about 41,126 (160)
Some of the next articles are maybe not open access.
Chicken mannose-binding lectin (MBL) gene variants with influence on MBL serum concentrations
Immunogenetics, 2013Mannose-binding lectin (MBL) plays a major role in the innate immune defence by activating the lectin complement pathway or by acting as an opsonin. Two forms of MBL have been characterised from several species, but for humans and chickens, only one form of functional MBL has been described.
Rikke M Kjærup +2 more
exaly +4 more sources
The responses of the gut microbiota to MBL deficiency
Molecular Immunology, 2020Mannose-binding lectin (MBL) deficiency is a common innate immune system deficiency, and is associated with exacerbations and increased colonization of some pathogens. However, the response of the gut microbiota, a pivotal factor in host health, to MBL deficiency is not clear. In this study, MBL-/- and wild-type (WT) mice were generated by backcrossing
Fanping Wang, Puze Li, Dong Yan
exaly +3 more sources
Posttranslational modifications in human plasma MBL and human recombinant MBL
Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, 2007Mannan-binding lectin (MBL) is a complex serum protein that plays an important role in innate immunity. In addition to assuming several different oligomeric forms, the polypeptide itself is highly heterogeneous. This heterogeneity is due to post-translational modifications, which help to stabilize the intact protein in its active conformation.
Jensen, Pia Hønnerup +3 more
openaire +2 more sources
Science, 1997
The Marine Biological Laboratory (MBL) at Woods Hole, Massachusetts, is pleased and flattered to be the subject of an “Institutional profile” (News & Comment, [17 Oct., p. 381][1]). This attention reflects the affection for the MBL in American biology and the special role of this venerable institution.
openaire +1 more source
The Marine Biological Laboratory (MBL) at Woods Hole, Massachusetts, is pleased and flattered to be the subject of an “Institutional profile” (News & Comment, [17 Oct., p. 381][1]). This attention reflects the affection for the MBL in American biology and the special role of this venerable institution.
openaire +1 more source
Infusion of plasma-derived mannan-binding lectin (MBL) into MBL-deficient humans
Biochemical Society Transactions, 2003Our first experience of mannan-binding lectin (MBL)-replacement therapy was with a patient experiencing recurrent erythema multiforme associated with reactivation of herpes simplex virus; his erythematous eruptions could be controlled with infusions of fresh frozen plasma containing MBL, but not with plasma lacking MBL.
openaire +2 more sources
MASP interactions with plasma-derived MBL
Molecular Immunology, 2012The interaction of mannan-binding lectin (MBL) with its associated serine proteases (MASPs) was investigated using recombinant (r) MBL, plasma-derived (pd) MBL, rMASP-3 and rMAp19. When mixed with MBL-deficient serum, rMBL and pdMBL associated with free MASP-2 to (re)gain complement-activating activity.
Inga A, Laursen +3 more
openaire +2 more sources
2016
In 1988, a year before Hurricane Hugo devastated many of the houses and downed the ancient hard wood trees in the area, we had purchased “Toti’s” cottage near the El Yunque Rain Forest on the northeast end of Puerto Rico (Fig. 5.1). Fortunately, Hugo’s damage to our cottage was limited to the low-pitched roof above the bedrooms in the rear of the house.
openaire +1 more source
In 1988, a year before Hurricane Hugo devastated many of the houses and downed the ancient hard wood trees in the area, we had purchased “Toti’s” cottage near the El Yunque Rain Forest on the northeast end of Puerto Rico (Fig. 5.1). Fortunately, Hugo’s damage to our cottage was limited to the low-pitched roof above the bedrooms in the rear of the house.
openaire +1 more source
Mannose binding lectin (MBL) and HIV
Molecular Immunology, 2005The envelope protein (gp120/gp41) of HIV-1 is highly glycosylated with about half of the molecular mass of gp120 consisting of N-linked carbohydrates. While glycosylation of HIV gp120/gp41 provides a formidable barrier for development of strong antibody responses to the virus, it also provides a potential site of attack by the innate immune system ...
Xin, Ji, Henry, Gewurz, Gregory T, Spear
openaire +2 more sources
Evaluation of Ethnic Differences in Mannose-Binding Lectin (MBL) Level or MBL Genotype.
Blood, 2006Abstract Background: MBL is a natural human plasma protein that plays an important role in the humoral innate immune defense. MBL specifically recognizes a broad range of microorganisms, including bacteria, fungi, viruses, and parasites, by binding to common carbohydrate structures located on their surfaces and activating the lectin ...
Aby Buchbinder +7 more
openaire +1 more source
The Journal of Immunology, 2016
Abstract Background and Aims Mannan-binding lectin (MBL) is a mediator of innate immunity, deficiency is associated with increased severity of infection. Pathogen recognition and complement activation functions are well characterised, however, mechanisms behind the reduced overall response to ...
Melinda M Dean +3 more
openaire +1 more source
Abstract Background and Aims Mannan-binding lectin (MBL) is a mediator of innate immunity, deficiency is associated with increased severity of infection. Pathogen recognition and complement activation functions are well characterised, however, mechanisms behind the reduced overall response to ...
Melinda M Dean +3 more
openaire +1 more source