Results 181 to 190 of about 93,738 (272)

Molecular Mechanism of Caspase‐8–Dependent Interleukin‐18 Activation in Pancreatic Cancer Cells Induced by 5‐Fluorouracil and Nutrient Starvation

open access: yesGenes to Cells, Volume 31, Issue 3, May 2026.
Nutrient starvation triggers pyroptosis with cleavage of pro‐IL‐18 and GSDMD in pancreatic cancer cells, and treatment of 5‐FU enhances this process. As a result, active IL‐18 is released and leads to inflammation. ABSTRACT Interleukin‐18 (IL‐18) is a pro‐inflammatory cytokine, and higher IL‐18 expression in pancreatic tumors is associated with poor ...
Hiroki Kamino   +2 more
wiley   +1 more source

Signal Transducer and Activator of Transcription (STAT) Proteins Regulate Mucosal‐Associated Invariant T (MAIT) Cell Function

open access: yesImmunology, Volume 178, Issue 1, Page 97-108, May 2026.
Integrated transcriptomic, proteomic and flow cytometry analyses reveal that STAT1 negatively regulates MAIT cell effector and glycolytic functions, while STAT3, STAT5 and HIF1α act as positive modulators. Targeting these pathways may offer new strategies to restore MAIT cell function in immune dysregulation and cancer.
Olivia J. Cheng   +7 more
wiley   +1 more source

Ceftazidime/avibactam and aztreonam combined with an aminoglycoside combat metallo-β-lactamase-producing <i>Klebsiella pneumoniae</i>. [PDF]

open access: yesAntimicrob Agents Chemother
Karunanidhi A   +10 more
europepmc   +1 more source

Nitrogen Stable Isotopes Track Ammonia Emission Sources and Ammonium Aerosol Formation Processes in the Marine Boundary Layer

open access: yesGeophysical Research Letters, Volume 53, Issue 8, 28 April 2026.
Abstract We measured the nitrogen isotopic composition of surface seawater and aerosol ammonium in the Weddell Sea region of the Southern Ocean to investigate the natural atmospheric cycle of marine ammonia emissions and aerosol ammonium formation in a region not overwhelmed by anthropogenic emissions.
K. E. Altieri   +5 more
wiley   +1 more source

The Role of MASP1, MASP2, and Mannose-Binding Lectin in the Immune Response to Hepatitis B Vaccination in Infants. [PDF]

open access: yesVaccines (Basel)
Tapcı AE   +9 more
europepmc   +1 more source

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

open access: yesFEBS Letters, Volume 600, Issue 7, Page 1073-1087, April 2026.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang   +8 more
wiley   +1 more source

Novel Insights into Carbapenem Resistance: Mechanisms, Diagnostics, and Future Directions. [PDF]

open access: yesAntibiotics (Basel)
Miftode IL   +9 more
europepmc   +1 more source

Bone Healing Around Implants in Normal and Medically Compromised Conditions: Osteoporosis and Diabetes

open access: yesAdvanced Healthcare Materials, Volume 15, Issue 16, 24 April 2026.
ABSTRACT Osseointegration of orthopedic and dental implants is influenced by local and systemic factors, including their physicochemical surface properties and the patient's overall health status. Titanium and its alloys have been a longstanding standard for bone implants due to their innate biocompatibility and mechanical properties.
Dainelys Guadarrama Bello   +2 more
wiley   +1 more source

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