Results 1 to 10 of about 189,511 (120)

Identification of an Outbreak Cluster of Extensively Antibiotic-Resistant GC1 Acinetobacter baumannii Isolates in U.S. Military Treatment Facilities

Microbiology Spectrum, 2023
An outbreak involving an extensively antibiotic-resistant Acinetobacter baumannii strain in three military treatment facilities was identified. Fifty-nine isolates recovered from 30 patients over a 4-year period were found among a large collection of ...
Ting L. Luo, Christopher J. Harmer, Francois Lebreton, Jason Stam, Jason W. Bennett, Ruth M. Hall, Patrick T. Mc Gann   +6 more
doaj   +1 more source

A one-year genomic investigation of Escherichia coli epidemiology and nosocomial spread at a large US healthcare network

Genome Medicine, 2022
Background Extra-intestinal pathogenic Escherichia coli (ExPEC) are a leading cause of bloodstream and urinary tract infections worldwide. Over the last two decades, increased rates of antibiotic resistance in E.
Emma G. Mills, Melissa J. Martin, Ting L. Luo, Ana C. Ong, Rosslyn Maybank, Brendan W. Corey, Casey Harless, Lan N. Preston, Joshua A. Rosado-Mendez, Scott B. Preston, Yoon I. Kwak, Michael G. Backlund, Jason W. Bennett, Patrick T. Mc Gann, Francois Lebreton   +14 more
doaj   +1 more source

Detection of OXA-181-producing Pseudomonas aeruginosa in Germany

International Journal of Medical Microbiology, 2022
Objectives: To report the detection of the class D carbapenemase OXA-181 in an MDR clinical Pseudomonas aeruginosa isolate in Germany. Methods: Carbapenemase detection was performed by using several phenotypic tests such as the modified Hodge test, a ...
Jennifer Schauer, Sören G. Gatermann, Jessica Eisfeld, Jörg Hans, Niels Pfennigwerth   +4 more
doaj   +1 more source

Mechanisms of IS26-Mediated Amplification of the aphA1 Gene Leading to Tobramycin Resistance in an Acinetobacter baumannii Isolate

Microbiology Spectrum, 2022
Enhanced levels of resistance to antibiotics arising from amplification of an antibiotic resistance gene that impact therapeutic options are increasingly observed. Amplification can also disclose novel phenotypes leading to treatment failure.
Christopher J. Harmer, Francois Lebreton, Jason Stam, Patrick T. McGann, Ruth M. Hall   +4 more
doaj   +1 more source

An Assessment of Siderophore Production, Mucoviscosity, and Mouse Infection Models for Defining the Virulence Spectrum of Hypervirulent Klebsiella pneumoniae

mSphere, 2021
The pathogenic potential of hvKp strains is primarily mediated by a large virulence plasmid. The minimal set of genes required for the full expression of the hypervirulent phenotype is undefined.
Thomas A. Russo, Ulrike MacDonald, Sidra Hassan, Ellie Camanzo, Francois LeBreton, Brendan Corey, Patrick McGann   +6 more
doaj   +1 more source

Pseudomonas Endocarditis with an unstable phenotype: the challenges of isolate characterization and Carbapenem stewardship with a partial review of the literature

Antimicrobial Resistance and Infection Control, 2017
Background Pseudomonas endocarditis is exceedingly rare, especially in patients without predisposing risks. We present such a case that included unexpected switches in antibacterial resistance profiles in two Pseudomonas aeruginosa (PA) strains with the ...
Emil Lesho, Erik Snesrud, Yoon Kwak, Ana Ong, Rosslyn Maybank, Maryrose Laguio-Vila, Ann R. Falsey, Mary Hinkle   +7 more
doaj   +1 more source

Amplification of Aminoglycoside Resistance Gene aphA1 in Acinetobacter baumannii Results in Tobramycin Therapy Failure

mBio, 2014
Gene amplification is believed to play an important role in antibiotic resistance but has been rarely documented in clinical settings because of its unstable nature.
Patrick McGann, Patrice Courvalin, Erik Snesrud, Robert J. Clifford, Eun-Jeong Yoon, Fatma Onmus-Leone, Ana C. Ong, Yoon I. Kwak, Catherine Grillot-Courvalin, Emil Lesho, Paige E. Waterman   +10 more
doaj   +1 more source

Genome-based analysis of Carbapenemase-producing Klebsiella pneumoniae isolates from German hospital patients, 2008-2014

Antimicrobial Resistance and Infection Control, 2018
Background By using whole genome sequence data we aimed at describing a population snapshot of carbapenemase-producing K. pneumoniae isolated from hospitalized patients in Germany between 2008 and 2014.
Laura Becker, Martin Kaase, Yvonne Pfeifer, Stephan Fuchs, Annicka Reuss, Anja von Laer, Muna Abu Sin, Miriam Korte-Berwanger, Sören Gatermann, Guido Werner   +9 more
doaj   +1 more source

Geographical differences of carbapenem non-susceptible Enterobacterales and Acinetobacter spp. in Germany from 2017 to 2019

Antimicrobial Resistance and Infection Control, 2022
Background Since May 2016, infection and colonisation with carbapenem non-susceptible Acinetobacter spp. (CRA) and Enterobacterales (CRE) have to be notified to health authorities in Germany. The aim of our study was to assess the epidemiology of CRA and
Anja von Laer, Tim Eckmanns, Benedikt Zacher, Niels Pfennigwerth, Sören G. Gatermann, Felix Reichert, Michaela Diercke, Gyde Steffen, Doris Altmann, Annicka Reuss   +9 more
doaj   +1 more source

The Birth and Demise of the ISApl1-mcr-1-ISApl1 Composite Transposon: the Vehicle for Transferable Colistin Resistance

mBio, 2018
The origin and mobilization of the ~2,609-bp DNA segment containing the mobile colistin resistance gene mcr-1 continue to be sources of uncertainty, but recent evidence suggests that the gene originated in Moraxella species.
Erik Snesrud, Patrick McGann, Michael Chandler   +2 more
doaj   +1 more source