Results 41 to 50 of about 904,396 (254)

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Multidrug Resistance in Fungi [PDF]

Eukaryotic Cell, 2007
One of the major advances serving to define the beginning of the era of modern medicine was the development of penicillin in the early 1940s as the first widely used antibiotic effective against microorganisms (reviewed in reference [111][1]). In what has become an all-too-common trend, antibiotic-
Kailash, Gulshan, W Scott, Moye-Rowley
openaire   +2 more sources

SHORT-TERM CHEMOTHERAPY REGIMEN OF MULTIDRUG-RESISTANT TUBERCULOSIS IN THE KYRGYZ REPUBLIC

Паёми Сино, 2018
Objective: To study the clinical course of tuberculosis (TB) with multiple drug resistance (MDR) in the treatment of short-term courses recommended by the WHO.
E.V. ZHDANOVA, G.K. TURDUMAMBETOVA
doaj   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Multidrug resistant bacteria characterization using NGS

, 2021
Multidrug resistant bacteria characterization using ...
Graţiela Grădişteanu Pîrcălăbioru (9967022), Alexandru Salceanu (9303227), Mara Neacșu (11433330)   +2 more
core   +1 more source

Magnetically Actuated Microrobot for Drug Delivery: Current Progress and Challenges

Advanced Robotics Research, EarlyView.
Magnetically actuated microrobots are reshaping targeted drug delivery through wireless propulsion, programmable materials, and localized therapeutic release. This review examines how fabrication, body material selection, structural architecture, loading mechanisms, and imaging‐guided control converge to enable microrobotic therapies while identifying ...
Yang Yang, David J. Cappelleri
wiley   +1 more source

Acute-onset postoperative endophthalmitis caused by multidrug-resistant Klebsiella pneumoniae

, 2014
Shekhar Sanghi,1 Avinash Pathengay,1 Animesh Jindal,1 Vishal Raval,2 Sameera Nayak,2 Savitri Sharma,3 Abhishek Bawdekar,1 Harry W Flynn Jr41Department of Ophthalmology, L V Prasad Eye Institute, GMR Varalakshmi Campus, Visakhapatnam, Andhra Pradesh ...
Nayak S, Sanghi S, Sharma S, Bawdekar A, Jindal A, Raval V, Flynn HW Jr, Pathengay A   +7 more
core   +2 more sources

Temporal fluctuation of multidrug resistant salmonella typhi haplotypes in the mekong river delta region of Vietnam. [PDF]

, 2011
BACKGROUND: typhoid fever remains a public health problem in Vietnam, with a significant burden in the Mekong River delta region. Typhoid fever is caused by the bacterial pathogen Salmonella enterica serovar Typhi (S.
Dolecek, Christiane, Vinh Chau, Nguyen Van, Kathryn E. Holt, Stephen Baker, Chau, Nguyen Van Vinh, Chau, Tran Thuy, Holt, Kathryn E., Tran Tinh Hien, Tran Vu Thieu Nga, Hoang, Nguyen Van Minh, Pham Thanh Duy, Campbell, James I, Gordon Dougan, Tran Thuy Chau, Farrar, Jeremy, Bui Huu Manh, Jeremy Farrar, Tran Thi Phi La, Holt, Kathryn E, La, Tran Thi Phi, James I. Campbell, Hien, Tran Tinh, James I Campbell, Kathryn E Holt, Nguyen Van Minh Hoang, Dougan, Gordan, Nguyen Van Vinh Chau, Kathryn E. Holt, Manh, Bui Huu, Dougan, Gordon, Campbell, James I., Duy, Pham Thanh, Nga, Tran Vu Thieu, Baker, Stephen, Christiane Dolecek, Vinh Chau Nguyen Van, Christiane Dolecek (74268), Hien Tran Tinh, Tran Thi Phi La (96008), Nguyen Van Minh Hoang (96023), Manh Bui Huu, Dolecek Christiane, James I. Campbell (74267), Hoang Nguyen Van Minh, Stephen Baker (30387), Tran Thuy Chau (96025), La Tran Thi Phi, Bui Huu Manh (233690), Baker Stephen, Jeremy Farrar (74677), Pham Thanh Duy (211365), Kathryn E. Holt (142621), Tran Tinh Hien (74675), Tran Vu Thieu Nga (211336), Dougan Gordon, Holt Kathryn E., Chau Tran Thuy, Gordon Dougan (30395), Nguyen Van Vinh Chau (75053), Nga Tran Vu Thieu, Campbell James I., Farrar Jeremy, Duy Pham Thanh   +62 more
core   +2 more sources

Engineering Microbial Particles for Next‐Generation Biomedical Platforms

Advanced Science, EarlyView.
Microbe‐derived particles (MDPs), which include extracellular vesicles, outer membrane vesicles, inclusion bodies, polysaccharide particles, and virus‐like particles, represent a rapidly expanding category of bioinspired nanomaterials. With their natural origin, intrinsic biocompatibility, and highly programmable functionality, MDPs serve as a ...
Yuting Li, Yunjie Lu, Ziyan Huang, Jianjiang Chen, Yanbin Liu, Lei Qin, Chao Wang, Yumin Wu   +7 more
wiley   +1 more source