Results 41 to 50 of about 1,009,118 (297)

Detecting, mapping, and suppressing the spread of a decade-long Pseudomonas aeruginosa nosocomial outbreak with genomics

eLife
Whole-genome sequencing is revolutionizing bacterial outbreak investigation, but its application to the clinic remains limited. In 2020, prospective and retrospective surveillance detected a Pseudomonas aeruginosa outbreak with 253 isolates collected ...
William Stribling, Lindsey R Hall, Aubrey Powell, Casey Harless, Melissa J Martin, Brendan W Corey, Erik Snesrud, Ana Ong, Rosslyn Maybank, Jason Stam, Katelyn V Bartlett, Brendan T Jones, Lan N Preston, Katherine F Lane, Bernadette Thompson, Lynn M Young, Yoon I Kwak, Alice E Barsoumian, Ana Elizabeth Markelz, John L Kiley, Robert J Cybulski, Jason W Bennett, Patrick T Mc Gann, Francois Lebreton   +23 more
doaj   +1 more source

IS26-Mediated Transfer of blaNDM–1 as the Main Route of Resistance Transmission During a Polyclonal, Multispecies Outbreak in a German Hospital

Frontiers in Microbiology, 2019
One of the most demanding challenges in infection control is the worldwide dissemination of multidrug-resistant (MDR) bacteria in clinical settings. Especially the increasing prevalence of carbapenemase producing Gram-negative pathogens poses an urgent ...
Robert E. Weber, Michael Pietsch, Andre Frühauf, Yvonne Pfeifer, Maria Martin, Dirk Luft, Sören Gatermann, Niels Pfennigwerth, Martin Kaase, Guido Werner, Stephan Fuchs   +10 more
doaj   +1 more source

Differences in genotype and virulence among four multidrug-resistant Streptococcus pneumoniae isolates belonging to the PMEN1 clone [PDF]

, 2011
We report on the comparative genomics and characterization of the virulence phenotypes of four <i>S. pneumoniae</i> strains that belong to the multidrug resistant clone PMEN1 (Spain^23F ST81).
Longwell Mark J., Mitchell, T.J., Dawid, S., Sá-Leão, Raquel, Tomasz, Alexander, Dahlgren Margaret E., Earl Joshua P., N Luisa Hiller, Ehrlich Garth D., Hillman, Todd A, Powell, E., Martin, D.P., Hu, F.Z., Tettelin Herve, Hu Fen Z., Hiller N. Luisa, Ehrlich, G.D., Sá-Leão, R., Tettelin, H., Azad Ahmed, Buchinsky, Farrel J, Dahlgren, Margaret E, Ehrlich, Garth D, Daugherty, S.C., Mitchell Timothy J., Timothy J Mitchell, Farrel J Buchinsky, Tomasz Alexander, Margaret E Dahlgren, Ezzo, S., Hiller, N.L., Eutsey, R.A., Powell, Evan, Martin Darren P., Ezzo, Suzanne, Post, J.C., Hiller, N Luisa, Longwell, Mark J, Benjamin Janto, Buchinsky, F.J., Evan Powell, Herve Tettelin, Garth D Ehrlich, de Lencastre Herminia, Dahlgren, M.E., Dawid, Suzanne, Rory A Eutsey, Daugherty Sean C., Tettelin, Herve, Daugherty, Sean C, Eutsey, Rory A, Alexander Tomasz, Fen Z Hu, Sá-Leão Raquel, Herminia de Lencastre, J Christopher Post, Dawid Suzanne, Post, J Christopher, Suzanne Dawid, Mark J Longwell, Powell Evan, Mitchell, Timothy J, Ahmed, Azad, Post J. Christopher, Joshua P Earl, Hillman Todd A., de Lencastre, H., Janto, Benjamin, Todd A Hillman, Janto Benjamin, Ezzo Suzanne, Earl, Joshua P, Tse, H., Raquel Sá-Leão, Eutsey Rory A., Darren P Martin, Buchinsky Farrel J., de Lencastre, Herminia, Ahmed, A., Suzanne Ezzo, Earl, J.P., Hu, Fen Z, Janto, B., Ahmed Azad, Sean C Daugherty, Martin, Darren P, Hillman, T.A., Longwell, M.J., Tomasz, A.   +88 more
core   +2 more sources

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Genomic Analysis of Clinical Multidrug Resistant E. coli in Nigerian Hospitals

, 2023
Escherichia coli is an emerging nosocomial pathogen causing problems in health care settings. The management of human infections caused by multidrug resistant (MDR) E. coli poses substantial clinical challenges in hospitals.
Asuquo, B.S., Okon, U.E., Mbim, E.N., Okoro, B., Mboto, C., Otong, M.M., Mohammed, M., Ekpo, C.   +7 more
core   +4 more sources

Multidrug Resistance in Fungi [PDF]

Eukaryotic Cell, 2007
One of the major advances serving to define the beginning of the era of modern medicine was the development of penicillin in the early 1940s as the first widely used antibiotic effective against microorganisms (reviewed in reference [111][1]). In what has become an all-too-common trend, antibiotic-
Kailash, Gulshan, W Scott, Moye-Rowley
openaire   +2 more sources

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

SHORT-TERM CHEMOTHERAPY REGIMEN OF MULTIDRUG-RESISTANT TUBERCULOSIS IN THE KYRGYZ REPUBLIC

Паёми Сино, 2018
Objective: To study the clinical course of tuberculosis (TB) with multiple drug resistance (MDR) in the treatment of short-term courses recommended by the WHO.
E.V. ZHDANOVA, G.K. TURDUMAMBETOVA
doaj   +1 more source