Results 51 to 60 of about 904,396 (254)
Hypervirulent Klebsiella pneumoniae causing aortitis retains its capsule and mucoviscosity and remains genotypically and phenotypically stable over time
Scientific ReportsAortitis due to hypervirulent Klebsiella pneumoniae (hvKp) in a Belarusian male from central New York is described. Isolates at the time of diagnosis (Kp031824-1, Kp031824-2) and after 12 weeks of antimicrobial therapy (Kp070124) were characterized ...Thomas A. Russo, Ulrike Carlino-MacDonald, Zachary J. Drayer, Connor J. Davies, Alan Hutson, Ting L. Luo, Melissa J. Martin, Patrick T. McGann, Francois Lebreton, Alan Sanders +9 moredoaj +1 more sourceMultidrug-Resistant Bacterial Colonization and Infections in Large Retrospective Cohort of Mechanically Ventilated COVID-19 Patients
Emerging Infectious Diseases, 2023
Few data are available on incidence of multidrug-resistant organism (MDRO) colonization and infections in mechanically ventilated patients, particularly during the COVID-19 pandemic.Davide Mangioni, Liliane Chatenoud, Jacopo Colombo, Emanuele Palomba, Fernando A. Guerrero, Matteo Bolis, Nicola Bottino, Giuseppe Breda, Maria V. Chiaruttini, Gabriele Fior, Manuela Marotta, Giovanni Massobrio, Caterina Matinato, Antonio Muscatello, Paola Previtali, Sara Santambrogio, Francesca Tardini, Gianluca Zuglian, Giacomo Grasselli, Roberto Fumagalli, Andrea Gori, Nino Stocchetti, Gianpaola Monti, Alessandra Bandera +23 moredoaj +1 more sourceNatural Products with Activity against Multidrug-Resistant Tumor Cells
, 2013 Multidrug resistance is the main mechanism by which cancers develop resistance to chemotherapeutic drugs. Consequently, it is also an important factor in the failure of many forms of chemotherapy.Camila Bernardes de Andrade Carli, Quilles, Marcela Bassi [UNESP], Marcela Bassi Quilles, Iracilda Zeppone Carlos, Bernardes de Andrade Carli, Camila [UNESP], Carlos, Iracilda Zeppone [UNESP] +5 morecore +1 more sourceThe Natural Product Corramycin Acts as a DNA Gyrase Poison and Overcomes Fluoroquinolone Resistance in Mycobacterium tuberculosis
Advanced Science, EarlyView.Corramycin, a myxobacterial natural product antibiotic, exhibits potent bactericidal activity against multidrug‐resistant Mycobacterium tuberculosis. The compound hijacks bacterial transporters such as BacA and OppABCD to enter the cell and inhibits DNA synthesis through a previously unrecognized mode of DNA gyrase poisoning, locking the enzyme in an ...Franziska Fries, Jennifer Herrmann, Michael Dal Molin, Yaëlle Wormser, Timo Risch, Yunsheng Gao, Gareth Prosser, Francesca Gubellini, Ariel Mechaly, Joshua B. Wallach, Anthony Castro, Arka Banerjee, Sari Rasheed, Alexander Horn, Mathias Müsken, Michael Kurz, Lindsay Sonnenkalb, Viola Dreyer, Stefan Niemann, Sönke Andres, Dirk Schnappinger, Uli Kazmaier, Norbert Reiling, Rolf Müller, Jan Rybniker, Stéphanie Petrella +25 morewiley +1 more sourceDifferences in genotype and virulence among four multidrug-resistant Streptococcus pneumoniae isolates belonging to the PMEN1 clone [PDF]
, 2011 We report on the comparative genomics and characterization of the virulence phenotypes of four <i>S. pneumoniae</i> strains that belong to the multidrug resistant clone PMEN1 (Spain<sup>23F</sup> ST81).Longwell Mark J., Mitchell, T.J., Dawid, S., Sá-Leão, Raquel, Tomasz, Alexander, Dahlgren Margaret E., Earl Joshua P., N Luisa Hiller, Ehrlich Garth D., Hillman, Todd A, Powell, E., Martin, D.P., Hu, F.Z., Tettelin Herve, Hu Fen Z., Hiller N. Luisa, Ehrlich, G.D., Sá-Leão, R., Tettelin, H., Azad Ahmed, Buchinsky, Farrel J, Dahlgren, Margaret E, Ehrlich, Garth D, Daugherty, S.C., Mitchell Timothy J., Timothy J Mitchell, Farrel J Buchinsky, Tomasz Alexander, Margaret E Dahlgren, Ezzo, S., Hiller, N.L., Eutsey, R.A., Powell, Evan, Martin Darren P., Ezzo, Suzanne, Post, J.C., Hiller, N Luisa, Longwell, Mark J, Benjamin Janto, Buchinsky, F.J., Evan Powell, Herve Tettelin, Garth D Ehrlich, de Lencastre Herminia, Dahlgren, M.E., Dawid, Suzanne, Rory A Eutsey, Daugherty Sean C., Tettelin, Herve, Daugherty, Sean C, Eutsey, Rory A, Alexander Tomasz, Fen Z Hu, Sá-Leão Raquel, Herminia de Lencastre, J Christopher Post, Dawid Suzanne, Post, J Christopher, Suzanne Dawid, Mark J Longwell, Powell Evan, Mitchell, Timothy J, Ahmed, Azad, Post J. Christopher, Joshua P Earl, Hillman Todd A., de Lencastre, H., Janto, Benjamin, Todd A Hillman, Janto Benjamin, Ezzo Suzanne, Earl, Joshua P, Tse, H., Raquel Sá-Leão, Eutsey Rory A., Darren P Martin, Buchinsky Farrel J., de Lencastre, Herminia, Ahmed, A., Suzanne Ezzo, Earl, J.P., Hu, Fen Z, Janto, B., Ahmed Azad, Sean C Daugherty, Martin, Darren P, Hillman, T.A., Longwell, M.J., Tomasz, A. +88 morecore +2 more sourcesArtificial Intelligence‐Guided Phenotypic Drug Repurposing Against Streptococcus pneumoniae
Advanced Science, EarlyView.Integrated artificial intelligence (AI) ensembles identify highly potent repurposed drugs against Streptococcus pneumoniae. Prospective virtual screening of 6747 drugs uncovers nine active candidates, including thiostrepton. This drug exhibits low picomolar potency and bypasses established resistance in multidrug‐resistant strains, demonstrating an ...Joshua S. Fitch, Muhammad D. Ariadi, Min Jung Kwun, Leonie Howells, Saiveth Hernandez‐Hernandez, Nicholas J. Croucher, Pedro J. Ballester +6 morewiley +1 more sourceRecurring acquisition of carbapenemase genes and global emergence of Pseudomonas aeruginosa ST-1047, a lineage shaped by geopolitical conflicts
mBioPseudomonas aeruginosa sequence type (ST)-1047 is emerging globally as a carbapenemase-rich lineage, yet its evolutionary history and population structure are not known.Ting L. Luo, Brendan T. Jones, Henry Dao, Viacheslav Kondratiuk, Valentyn Kovalchuk, Nadiia Fomina, Frieder Fuchs, Denis K. Byarugaba, Fred Wabwire-Mangeni, Hannah Kibuuka, Jason R. Smedberg, Ana C. Ong, Yoon I. Kwak, Antoni P. A. Hendrickx, Jason W. Bennett, Francois Lebreton, Patrick T. McGann +16 moredoaj +1 more sourceAn intervention to control an ICU outbreak of carbapenem-resistant Acinetobacter baumannii: long-term impact for the ICU and hospital
Critical Care, 2018 Background Following a fatal intensive care unit (ICU) outbreak of carbapenem-resistant Acinetobacter baumanii (CRAB) in 2015, an aggressive infection control intervention was instituted. We outline the intervention and long-term changes in the incidence Eli Ben-Chetrit, Yonit Wiener-Well, Emil Lesho, Puah Kopuit, Chaya Broyer, Liora Bier, Marc V. Assous, Shmuel Benenson, Matan J. Cohen, Patrick T. McGann, Erik Snesrud, Phillip D. Levin +11 moredoaj +1 more sourceSemanticST: A Scalable Multi‐Contextual Graph Learning Framework for Uncovering Spatial Niches and Robust Multi‐Sample Integration in Spatial Transcriptomics
Advanced Science, EarlyView.Technical limitations often let dominant signals overshadow rare cell types and fine‐grained heterogeneity in spatial transcriptomics. SemanticST, a graph neural network using multi‐semantic graph fusion and a novel min‐cut loss, recovers these subtle patterns.Roxana Zahedi, Ahmadreza Argha, Nona Farbehi, Ivan Bakhshayeshi, Thantrira Porntaveetus, Youqiong Ye, Nigel H. Lovell, Hamid Alinejad‐Rokny +7 morewiley +1 more source
