Results 71 to 80 of about 306,632 (271)

Molecular surveillance of carbapenemase-producing Pseudomonas aeruginosa at three medical centres in Cologne, Germany

Antimicrobial Resistance and Infection Control, 2019
Background Pseudomonas aeruginosa is a common pathogen causing hospital-acquired infections. Carbapenem resistance in P. aeruginosa is either mediated via a combination of efflux pumps, AmpC overexpression, and porin loss, or through an acquired ...
Elena Schäfer, Monika Malecki, Carlos J. Tellez-Castillo, Niels Pfennigwerth, Lennart Marlinghaus, Paul G. Higgins, Frauke Mattner, Andreas F. Wendel   +7 more
doaj   +1 more source

Restoration of Taxol Sensitivity of Multidrug-Resistant Cells by the Cyclosporine SDZ PSC 833 and the Cyclopeptolide SDZ 280-446 [PDF]

, 2017
Background: Taxol, a promising agent for the treatment of cancer, has entered phase II clinical trials. Nevertheless, it belongs to the class of compounds that show impaired retention in multidrug-resistant cells expressing P-glycoprotein (Pgp), a drug ...
Jachez, Bénédicte, Loor, Francis, Nordmann, Rene   +2 more
core  

Rationing tests for drug-resistant tuberculosis - who are we prepared to miss? [PDF]

, 2016
BACKGROUND: Early identification of patients with drug-resistant tuberculosis (DR-TB) increases the likelihood of treatment success and interrupts transmission.
A Faustini, A Pantoja, A Pooran, A Vassall, C Fitzpatrick, D Martínez, D Menzies, DAJ Moore, DAJ Moore, David A. J. Moore, E Tortoli, EA Kendall, EL Corbett, GJ Churchyard, JC Feres, Jon S. Friedland, Jorge Coronel, K Kliiman, KAK Angeby, L Caviedes, Laura J. Martin, Louis Grandjean, Luz Caviedes, MA Espinal, Martha H. Roper, O Oxlade, P Miotto, PG Suárez, PT Kent, Robert H. Gilman, SS Shin, V Boonsarngsuk, World Health Organization, World Health Organization, World Health Organization, World Health Organization   +35 more
core   +4 more sources

Enhanced Infection Resistance and Regenerative Healing of Titanium Implants via Peptide‐Loaded Biodegradable Coatings

Advanced Materials Technologies, EarlyView.
This study presents a new biodegradable coating for titanium implants using a natural antimicrobial peptide, caerin 1.9. Applied via solvent casting, the coating offers sustained antibacterial protection and promotes healing. Tested on 3D‐printed porous titanium scaffolds, it effectively prevented infection—including against resistant bacteria—while ...
Hejie Li, Tianfang Wang, Nicolas Soro, Guoying Ni, Meg Allom, D. İpek Kurtböke, Xiaosong Liu, Damon Kent   +7 more
wiley   +1 more source

From Orange to Oncology: Anti-Inflammatory and Anti-Cancer Mechanisms of Sinensetin

Cells
Sinensetin, a polymethoxylated flavone abundant in citrus fruits, has been recognized for its broad biological activities and wide use in traditional medicine around the world. Emerging clinical evidence from flavonoid-enriched orange juice interventions
Dong Joon Kim, Songyeon Ahn, Xiaomeng Xie, Yeon-Sun Seong, Yong Weon Yi   +4 more
doaj   +1 more source

Emergence of Multidrug Resistant Hypervirulent ST23 Klebsiella pneumoniae: Multidrug Resistant Plasmid Acquisition Drives Evolution

Frontiers in Cellular and Infection Microbiology, 2020
BackgroundIn recent years, the emergence of multidrug resistant hypervirulent K. pneumoniae (MDR hvKp) isolates poses severe therapeutic challenge to global public health.
Chaitra Shankar, Jobin John Jacob, Karthick Vasudevan, Rohit Biswas, Abi Manesh, Dhiviya Prabaa Muthuirulandi Sethuvel, Santosh Varughese, Indranil Biswas, Balaji Veeraraghavan   +8 more
doaj   +1 more source

Multi-drug resistant Gram-negative bacteria: antibiotic-resistance and new treatment strategies [PDF]

, 2017
In this editorial, we treat the multi-drug-resistance of microorganisms such as Klebsiella pneumonia (Kp) and Acinetobacter baumanii and the issues concerning the management of these infections.
Angelis, Massimiliano De, Mascellino, Maria Teresa, Oliva, Alessandra   +2 more
core   +1 more source

Discovery of H2 Receptor Antagonists as Colistin Enhancers by Targeting Acid Stress Response

Advanced Science, EarlyView.
This study identifies YqgB as a key target for restoring colistin susceptibility in mcr‐positive pathogens under acidic conditions by remodeling phospholipid composition and reducing LPS modification. Deep learning‐based screening reveals H2 receptor antagonists as novel colistin adjuvants. Further investigations indicate that ranitidine and famotidine
Jinju Cai, Mengping He, Jianya Luo, Shuang Zhou, Tengyue Zhang, Jianing Li, Zhiqiang Wang, Yuan Liu   +7 more
wiley   +1 more source

Attributable deaths and disability-adjusted life-years caused by infections with antibiotic-resistant bacteria in the EU and the European Economic Area in 2015: a population-level modelling analysis [PDF]

, 2018
Background: Infections due to antibiotic-resistant bacteria are threatening modern health care. However, estimating their incidence, complications, and attributable mortality is challenging.
Abu Sin, Muna, Andrasevic, Arjana Tambic, Aracil, Belen, Asensio, Angel, Billstrom, Hanna, Borg, Michael A., Budimir, Ana, Burns, Karen, Canica, Manuela, Cassini, Alessandro, Catry, Boudewijn, Cecchini, Michele, Coignard, Bruno, Colomb-Cotinat, Melanie, Daikos, George L., de Greeff, Sabine C., Deptula, Aleksander, Devleesschauwer, Brecht, Dobreva, Elina Georgieva, Dsstat, Patrizio Pezzotti, Dumpis, Uga, Eckmanns, Tim, Elstrom, Petter, Fernandes, Paulo Andre, Gagliotti, Carlo, Gikas, Achilleas, Guolaugsson, Olafur, Hajdu, Agnes, Haller, Sebastian, Hogberg, Liselotte Diaz, Hopkins, Susan, Hoxha, Ana, Hryniewicz, Waleria, Ivanov, Ivan Nikolaev, Ivanova, Marina, Jalava, Jari, Johnson, Alan, Klavs, Irena, Koek, Mayke B. G., Kolman, Jana, Kontopidou, Flora, Korosec, Ales, Kretzschmar, Mirjam E., Kristinsson, Karl G., Larsson, Sofie, Latour, Katrien, Litvova, Slavka, Liuimiene, Agne, Lyytikainen, Outi, Manageiro, Vera, Martin, Pille, Mertens, Karl, Monen, Jos C. M., Monnet, Dominique L., Murchan, Stephen, Nogueira, Paulo Jorge, Oliveira, Tiago Cravo, Olsen, Stefan Schytte, Ouakrim, Driss Ait, Paphitou, Niki, Perez-Vazquez, Maria, Perrin, Monique, Plachouras, Diamantis, Popescu, Gabriel Adrian, Quattrocchi, Annalisa, Reilly, Jacqui S., Schreterova, Eva, Serban, Roxana Ioana, Simonsen, Gunnar Skov, Sonksen, Ute Wolff, Soprek, Silvija, Stefkovicova, Maria, Strauss, Reinhild, Struelens, Marc J., Struyf, Thomas, Suetens, Carl, Toth, Akos, Tsiodras, Sotirios, Zabicka, Dorota, Zemlickova, Helena   +79 more
core   +6 more sources

Understanding and Overcoming Antibody‐Drug Conjugate Resistance: Biological Mechanisms and Emerging Analytical Frameworks in Breast Cancer

Advanced Science, EarlyView.
Antibody–drug conjugates (ADCs) transform breast cancer therapy, yet resistance limits their durability. Emerging evidence reveals that ADC failure is not solely tumor‐intrinsic but shaped by dynamic tumor–microenvironment interactions that alter drug delivery, processing, and response.
Minji Seo, Jangsoon Lee, Naoto T. Ueno
wiley   +1 more source