Results 81 to 90 of about 181,836 (261)

Targeting Lipopolysaccharide Transport Induces Membrane Lipid Remodeling and Sensitizes Acinetobacter baumannii to Colistin Treatment

Advanced Science, EarlyView.
This study identifies C4 as a lead inhibitor of the Lpt system. Notably, C4 potentiates colistin activity by disrupting LPS transport and remodeling phospholipid homeostasis, revealing a functional interplay between the Lpt and Mla systems. These findings establish a mechanistic link between Lpt inhibition and membrane lipid remodeling, positioning Lpt–
Jianya Luo, Hetianzi Zhang, Jinju Cai, Shuang Zhou, Haijie Zhang, Zhiqiang Wang, Yuan Liu   +6 more
wiley   +1 more source

REGγ Suppresses Ferroptosis and Induces Drug Resistance by Degrading WDR6 in Chondrosarcoma

Advanced Science, EarlyView.
Here, we identified REGγ as a susceptibility factor in chondrosarcoma. Our study demonstrates that abnormally activated REGγ‐20S proteasome promotes chondrosarcoma development and progression. Further validation in animal models revealed that blocking REGγ function induced ferroptosis, suppressed malignant progression of chondrosarcoma, and uncovered a
Fanrong Liu, Shihui Shen, Dongxia Li, Peilin Shi, Jiaming Xu, Tongxin Lv, Yingying Du, Jingwei Zhang, Bo Yang, Hansen Chen, Zhuoya Peng, Wenjie Ren, Lu Zhang, Sheng Cheng, Tongjin Yin, Wencai Sheng, Lei Li, Juan Wu, Qingcheng Yang, Shuogui Xu, Wei Zheng   +20 more
wiley   +1 more source

Unveiling a hidden threat: whole genome sequencing exposes the cross-hospital spread of extensively drug-resistant Pseudomonas aeruginosa

Frontiers in Microbiology
IntroductionWhole genome sequencing (WGS) was performed on 10 extensively drug-resistant (XDR) Pseudomonas aeruginosa ST235 isolates to investigate potential healthcare-associated transmission of XDR P. aeruginosa ST235 within a U.S.
Edwin Kamau, Brendan Jones, Tatdanai Kitjawat, Han Ha Youn, Michael J. Schweikert, Angela Caldwell, Christopher Harens, Patrick T. Kiernan, John Mark Velasco, John Mark Velasco, Francois Lebreton, Nathanial K. Copeland   +11 more
doaj   +1 more source

Guidelines for Detecting the Foodborne Antibiotic‐Resistant Bacteria

AgriFood: Journal of Agricultural Products for Food, EarlyView.
ABSTRACT Foodborne antibiotic‐resistant bacteria threaten global public health and the economic. Standardized detection methods are crucial for effective prevention and control. Researchers encounter difficulties in choosing suitable techniques due to the variety of available approaches and the intricate nature of resistance mechanisms.
Yuanye Zeng, Fengxia Yang
wiley   +1 more source

SARS-CoV-2 infections in patients, health care workers and hospital outbreaks during the first 3 waves of the pandemic: a retrospective analysis in a secondary care hospital network in Germany

BMC Infectious Diseases
Background Hospital infections with SARS-CoV-2 continued during the initial waves of the pandemic worldwide. So far, Data on the dynamics of these infections and the economic burden of outbreaks are rare.
Anke Hildebrandt, Kirsten Dolega, Lutz Uflacker, Henrik Rudolf, Sören G. Gatermann   +4 more
doaj   +1 more source

Multidrug-Resistant Fungi

Journal of Fungi
Multidrug resistance in fungi is a growing challenge to global public health, resulting in ineffective treatments and thus high mortality rates [...]
Daniel Clemente de Moraes, Antônio Ferreira-Pereira   +1 more
openaire   +3 more sources

The Role of the Gut Microbiota in Allogeneic Hematopoietic Cell Transplantation

American Journal of Hematology, EarlyView.
ABSTRACT Allogeneic hematopoietic cell transplantation (allo‐HCT) is an effective treatment for patients with high‐risk hematologic malignancies. Over the last decade, gut microbiota composition during allo‐HCT has been associated with patients' outcomes.
Wenjing Hao, Nicolas Stocker, Béatrice Gaugler, Mohamad Mohty, Florent Malard   +4 more
wiley   +1 more source

Candida auris surveillance in the Military Health System: a multidrug-resistant threat

Antimicrobial Stewardship & Healthcare Epidemiology
Objective: To evaluate the potential sources and current screening strategies for the multidrug-resistant fungal pathogen Candida auris in the US Military Health System (MHS).
J. Joseph Brough, Graham C. Ellis, Sara L. Robinson, John L. Kiley, David D. Blaney, Michelle Dressner, Jason Stam, Jamie Myers, Ethan Green, Michelle Wagner, Kelly Andrews, Daniel Krauth, Dianne Frankel   +12 more
doaj   +1 more source

Methicillin-Resistant Staphylococcus aureus as a Probable Cause of Antibiotic-Associated Enterocolitis

Case Reports in Infectious Diseases, 2018
Antibiotic-associated diarrhea is typically associated with Clostridium difficile. However, Staphylococcus aureus has also been described as a cause of antibiotic-associated enterocolitis and diarrhea and is likely an underrecognized etiology. We present
Alison B. Lane, Nathanial K. Copeland, Fatma Onmus-Leone, James V. Lawler   +3 more
doaj   +1 more source

Stopping an outbreak of Pseudomonas aeruginosa ST111 by temporarily blocking the siphon to disinfect it before the transition to the wastewater drain

GMS Hygiene and Infection Control
Introduction: Resulting from an analysis of an outbreak of carbapenem-resistant Pseudomonas (P.) aeruginosa, the siphons of washbasins in patient rooms were identified as source of colonizations and/or infections.
Torsten Stein, Martin Exner, Lisa-Marie Höfken, Katrin Schuldt, Axel Kramer   +4 more
doaj   +1 more source