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Accessory Genomic Epidemiology of Cocirculating Acinetobacter baumannii Clones.

open access: yesMSystems, 2021
Whole-genome sequencing for epidemiological investigations (genomic epidemiology) has been of paramount importance to understand the transmission dynamics of many bacterial (and nonbacterial) pathogens.
José Luis Fernández-Vázquez   +2 more
exaly   +3 more sources

Global Distribution of mcr Gene Variants in 214K Metagenomic Samples

open access: yesmSystems, 2022
Since the initial discovery of a mobilized colistin resistance gene (mcr-1), several other variants have been reported, some of which might have circulated a while beforehand.
Hannah-Marie Martiny   +5 more
doaj   +1 more source

Benzodiazepine-related dementia risks and protopathic biases revealed by multiple-kernel learning with electronic medical records

open access: yesDigital Health, 2023
Objectives To simultaneously estimate how the risk of incident dementia nonlinearly varies with the administration period and cumulative dose of benzodiazepines, the duration of disorders with an indication for benzodiazepines, and other potential ...
Takashi Hayakawa   +5 more
doaj   +1 more source

A Peek into the Plasmidome of Global Sewage

open access: yesmSystems, 2021
This is, to the best of our knowledge, the first study to investigate plasmidomes at a global scale using long read sequencing from complex untreated domestic sewage.
Philipp Kirstahler   +4 more
doaj   +1 more source

Genomic analysis of sewage from 101 countries reveals global landscape of antimicrobial resistance

open access: yesNature Communications, 2022
Understanding the emergence, evolution, and transmission of antibiotic resistance genes (ARGs) is essential to combat antimicrobial resistance. Here, Munk et al. analyse ARGs in hundreds of sewage samples from 101 countries and describe regional patterns,
Patrick Munk   +14 more
doaj   +1 more source

Metagenomics analysis of bacteriophages and antimicrobial resistance from global urban sewage

open access: yesScientific Reports, 2021
Bacteriophages, or phages, are ubiquitous bacterial and archaeal viruses with an estimated total global population of 1031. It is well-known that wherever there are bacteria, their phage counterparts will be found, aiding in shaping the bacterial ...
Josephine E. S. Strange   +3 more
doaj   +1 more source

Global Distribution and Diversity of Prevalent Sewage Water Plasmidomes

open access: yesmSystems, 2022
Sewage water from around the world contains an abundance of short plasmids, several of which harbor antimicrobial resistance genes (ARGs). The global dynamics of plasmid-derived antimicrobial resistance and functions are only starting to be unveiled ...
Frederik Teudt   +2 more
doaj   +1 more source

Insights into malaria susceptibility using genome-wide data on 17,000 individuals from Africa, Asia and Oceania

open access: yesNature Communications, 2019
Four genome-wide associated loci are currently known for malaria susceptibility. Here, the authors expand on earlier work by combining data from 11 malaria-endemic countries and additional population sequencing informing an African-enriched imputation ...
Malaria Genomic Epidemiology Network
doaj   +1 more source

Modelling the effectiveness of surveillance based on metagenomics in detecting, monitoring, and forecasting antimicrobial resistance in livestock production under economic constraints

open access: yesScientific Reports, 2023
Current surveillance of antimicrobial resistance (AMR) is mostly based on testing indicator bacteria using minimum inhibitory concentration (MIC) panels. Metagenomics has the potential to identify all known antimicrobial resistant genes (ARGs) in complex
Ofosuhene O. Apenteng   +2 more
doaj   +1 more source

Salmonella Derby adaptation to swine and simultaneous attenuation for humans go through decay of Salmonella Pathogenicity Island I

open access: yesMicrobiology Spectrum, 2023
We report the identification, within the global population of Salmonella Derby, of a lineage highly diffused and expanding in swine while being significantly under-represented in humans which carries stop mutations in the Salmonella Pathogenicity Island ...
Melissa Berni   +8 more
doaj   +1 more source

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