Results 21 to 30 of about 181,836 (261)

Near-ubiquitous presence of a vancomycin-resistant Enterococcus faecium ST117/CT71/vanB –clone in the Rhine-Main metropolitan area of Germany

Antimicrobial Resistance and Infection Control, 2019
Whole-genome sequencing analysis of Vancomycin-resistant Enterococcus faecium isolates from the Frankfurt metropolitan region revealed that 78/94 isolates were MLST type ST117, cgMLST complex type CT71 with a common vanB chromosomal insertion site.
Linda Falgenhauer, Moritz Fritzenwanker, Can Imirzalioglu, Katrin Steul, Marlene Scherer, Rhine-Main VREfm study group, Ursel Heudorf, Trinad Chakraborty   +7 more
doaj   +1 more source

Does antibiotic prophylaxis for dental treatment prevent periprosthetic infections?

GMS Infectious Diseases
Background: The German Society for Arthroplasty (AE) recommends a single dose of 2,000 mg amoxicillin as an antibiotic prophylaxis to prevent periprosthetic joint infections (PJI) in patients with total hip or knee arthroplasty (THA, TKA) who undergo ...
Ursel Heudorf, Rolf Tessmann, Klaus-Peter Hunfeld   +2 more
doaj   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

High genetic relatedness between multidrug resistant bacteria before and after the 2022 invasion of Ukraine

Genome Medicine
Background The Russian invasion of Ukraine in 2022 has placed extraordinary pressure on hospitals there. One consequence of this has been the alarming increase in infections caused by multi-drug resistant organisms (MDROs), both within Ukraine and among ...
Francois Lebreton, Viacheslav Kondratiuk, Valentyn Kovalchuk, Niels Pfennigwerth, Ting L. Luo, Brendan T. Jones, Nadiia Fomina, Frieder Fuchs, Jörg B. Hans, Jessica Eisfeld, Ana Ong, Sören Gatermann, Jason W. Bennett, Patrick Mc Gann   +13 more
doaj   +1 more source

Detecting, mapping, and suppressing the spread of a decade-long Pseudomonas aeruginosa nosocomial outbreak with genomics

eLife
Whole-genome sequencing is revolutionizing bacterial outbreak investigation, but its application to the clinic remains limited. In 2020, prospective and retrospective surveillance detected a Pseudomonas aeruginosa outbreak with 253 isolates collected ...
William Stribling, Lindsey R Hall, Aubrey Powell, Casey Harless, Melissa J Martin, Brendan W Corey, Erik Snesrud, Ana Ong, Rosslyn Maybank, Jason Stam, Katelyn V Bartlett, Brendan T Jones, Lan N Preston, Katherine F Lane, Bernadette Thompson, Lynn M Young, Yoon I Kwak, Alice E Barsoumian, Ana Elizabeth Markelz, John L Kiley, Robert J Cybulski, Jason W Bennett, Patrick T Mc Gann, Francois Lebreton   +23 more
doaj   +1 more source

IS26-Mediated Transfer of blaNDM–1 as the Main Route of Resistance Transmission During a Polyclonal, Multispecies Outbreak in a German Hospital

Frontiers in Microbiology, 2019
One of the most demanding challenges in infection control is the worldwide dissemination of multidrug-resistant (MDR) bacteria in clinical settings. Especially the increasing prevalence of carbapenemase producing Gram-negative pathogens poses an urgent ...
Robert E. Weber, Michael Pietsch, Andre Frühauf, Yvonne Pfeifer, Maria Martin, Dirk Luft, Sören Gatermann, Niels Pfennigwerth, Martin Kaase, Guido Werner, Stephan Fuchs   +10 more
doaj   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Epidemic characteristics and drug resistance of tuberculosis in North China

Heliyon, 2020
To analyze the epidemiological characteristics and drug resistance of tuberculosis (TB) patients in northern China. The epidemiological characteristics of 620 patients with tuberculosis from 2014 to 2016 were analyzed, including gender, age, occupation ...
Zheng Qi, Xi Gao, Yan-fu Wang, Chang Liu
doaj   +1 more source