Results 11 to 20 of about 181,836 (261)

Multidrug Resistance in Fungi [PDF]

open access: yesEukaryotic Cell, 2007
One of the major advances serving to define the beginning of the era of modern medicine was the development of penicillin in the early 1940s as the first widely used antibiotic effective against microorganisms (reviewed in reference [111][1]). In what has become an all-too-common trend, antibiotic-
Kailash, Gulshan, W Scott, Moye-Rowley
openaire   +2 more sources

Amplification of Aminoglycoside Resistance Gene aphA1 in Acinetobacter baumannii Results in Tobramycin Therapy Failure

open access: yesmBio, 2014
Gene amplification is believed to play an important role in antibiotic resistance but has been rarely documented in clinical settings because of its unstable nature.
Patrick McGann   +10 more
doaj   +1 more source

Multidrug-resistant tuberculosis [PDF]

open access: yesBMC Infectious Diseases, 2008
With almost 9 million new cases each year, tuberculosis remains one of the most feared diseases on the planet. Led by the STOP-TB Partnership and WHO, recent efforts to combat the disease have made considerable progress in a number of countries. However, the emergence of mutated strains of Mycobacterium tuberculosis that are resistant to the major anti-
McNerney Ruth, Zager Ellen M
openaire   +4 more sources

Genome-based analysis of Carbapenemase-producing Klebsiella pneumoniae isolates from German hospital patients, 2008-2014

open access: yesAntimicrobial Resistance and Infection Control, 2018
Background By using whole genome sequence data we aimed at describing a population snapshot of carbapenemase-producing K. pneumoniae isolated from hospitalized patients in Germany between 2008 and 2014.
Laura Becker   +9 more
doaj   +1 more source

Multidrug-Resistant Tuberculosis

open access: yesChest, 2006
Multidrug-resistant tuberculosis (MDR-TB) caused by Mycobacterium tuberculosis resistant to both isoniazid and rifampicin with or without resistance to other drugs is among the most worrisome elements of the pandemic of antibiotic resistance. Globally, about three per cent of all newly diagnosed patients have MDR-TB.
S K, Sharma, A, Mohan
openaire   +2 more sources

Geographical differences of carbapenem non-susceptible Enterobacterales and Acinetobacter spp. in Germany from 2017 to 2019

open access: yesAntimicrobial Resistance and Infection Control, 2022
Background Since May 2016, infection and colonisation with carbapenem non-susceptible Acinetobacter spp. (CRA) and Enterobacterales (CRE) have to be notified to health authorities in Germany. The aim of our study was to assess the epidemiology of CRA and
Anja von Laer   +9 more
doaj   +1 more source

A light in multidrug resistance: Photodynamic treatment of multidrug-resistant tumors

open access: yesJournal of Biomedical Science, 2003
The major drawback of cancer chemotherapy is the development of multidrug-resistant (MDR) tumor cells, which are cross-resistant to a broad range of structurally and functionally unrelated agents, making it difficult to treat these tumors. In the last decade, a number of authors have studied the effects of photodynamic therapy (PDT), a combination of ...
Márcia Alves Marques, Capella   +1 more
openaire   +2 more sources

The Birth and Demise of the ISApl1-mcr-1-ISApl1 Composite Transposon: the Vehicle for Transferable Colistin Resistance

open access: yesmBio, 2018
The origin and mobilization of the ~2,609-bp DNA segment containing the mobile colistin resistance gene mcr-1 continue to be sources of uncertainty, but recent evidence suggests that the gene originated in Moraxella species.
Erik Snesrud   +2 more
doaj   +1 more source

Molecular characterization of multidrug-resistant ESKAPEE pathogens from clinical samples in Chonburi, Thailand (2017–2018)

open access: yesBMC Infectious Diseases, 2022
Background ESKAPEE pathogens Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, Enterobacter spp.
Sirigade Ruekit   +16 more
doaj   +1 more source

TnCentral: a Prokaryotic Transposable Element Database and Web Portal for Transposon Analysis

open access: yesmBio, 2021
The ability of bacteria to undergo rapid evolution and adapt to changing environmental circumstances drives the public health crisis of multiple antibiotic resistance, as well as outbreaks of disease in economically important agricultural crops and ...
Karen Ross   +8 more
doaj   +1 more source

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