Results 21 to 30 of about 481,129 (243)

محاسبات مکانیک مولکولی و بررسی تأثیر حلال بر اثرات محیطی و ترمودینامیکی آنزیم کولین استیل ترانسفراز [PDF]

مجله دانشگاه علوم پزشکی سبزوار, 1970
چکیده زمینه و هدف: فعالیت استیل کولین و آنزیم استیل کولین ترانسفراز در بیماری آلزایمر بررسی و مشخص شده است. از این جهت، نقص آنها می‌تواند باعث کاهش حافظه و یادگیری شود. میدان‌های نیرو، بر ساختار کولین استیل ترانسفراز تأثیر دارند.
ریحانه صباغزاده
doaj  

Utility of Computed Tomography Surveillance of Asymptomatic Infection in Children and Young Adults Before Allogeneic Hematopoietic Stem Cell Transplant

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Asymptomatic infection poses a significant risk for children undergoing hematopoietic stem cell transplantation (HSCT). Pre‐transplant surveillance computed tomography (CT) is commonly used to identify occult infection, though its diagnostic yield remains uncertain.
Tyler Obermark, Pradipta Debnath, Rama S. Ayyala, Lara A. Danziger‐Isakov, Jane Koo, Kasiani C. Myers, William R. Otto, Aki Tanimoto, Andrew T. Trout, Cara E. Morin   +9 more
wiley   +1 more source

Effects of Cancer Treatment on Somatosensory and Nociceptive Processing in Children and Adolescents: A Systematic Review

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Chemotherapy‐induced peripheral neuropathy remains a major complication in pediatric cancer, with disrupted somatosensory and nociceptive processing being a key aspect. This review synthesizes empirical studies on alterations in somatosensory and nociceptive processing in children and adolescents with cancer.
Julia Schweiger, Laura Walz, Michael C. Frühwald, Stefan Lautenbacher, Miriam Kunz   +4 more
wiley   +1 more source

Anatomical pathways involved in generating and sensing rhythmic whisker movements

Frontiers in Integrative Neuroscience, 2011
The rodent whisker system is widely used as a model system for investigating sensorimotor integration, neural mechanisms of complex cognitive tasks, neural development, and robotics.
Laurens W.J. Bosman, Laurens W.J. Bosman, Arthur R. Houweling, Cullen B. Owens, Nouk eTanke, Olesya T. Shevchouk, Negah eRahmati, Wouter H.T. Teunissen, Chiheng eJu, Wei eGong, Sebastiaan K.E. Koekkoek, Chris I De Zeeuw, Chris I De Zeeuw   +12 more
doaj   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Effect of arthritic synovial fluids on the expression of immunomodulatory factors by mesenchymal stem cells: an explorative in-vitro study

Frontiers in Immunology, 2012
Background: In diseased joints, the catabolic environment results in progressive joint damage. Mesenchymal stem cells (MSCs) can have immunomodulatory effect by secreting anti-inflammatory factors. To exert these effects, MSCs need to be triggered by pro-
Maarten J.C. Leijs, Gerben M. Van Buul, Gerben M. Van Buul, Erik eLubberts, Pieter K. Bos, Jan A.N. Verhaar, Martin J. Hoogduijn, Gerjo J.V.M. van Osch, Gerjo J.V.M. van Osch   +8 more
doaj   +1 more source

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

FEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang, Satoshi Hashimoto, Sota Ito, Chisato Kikuguchi, Miho Hoshi, Kiyoshi Yamaguchi, Yoichi Furukawa, Toru Suzuki, Toshifumi Inada   +8 more
wiley   +1 more source

Effects of Hypoxia on the Immunomodulatory properties of Adipose tissue-derived Mesenchymal Stem Cells

Frontiers in Immunology, 2013
Adipose tissue-derived mesenchymal stem cells (ASC) are of great interest as a cellular therapeutic agent for regenerative and immunomodulatory purposes. The function of ASC adapts to environmental conditions, such as oxygen tension. Oxygen levels within
M eRoemeling-Van Rhijn, F KF Mensah, S S Korevaar, M JC Leijs, G JVM van Osch, J NM IJzermans, M GH Betjes, C C Baan, W eWeimar, M J Hoogduijn   +9 more
doaj   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Low-dose cyclophosphamide depletes circulating naïve and activated regulatory T cells in malignant pleural mesothelioma patients synergistically treated with dendritic cell-based immunotherapy

OncoImmunology, 2018
Rationale: Regulatory T cells (Treg) play a pivotal role in the immunosuppressive tumor micro-environment in cancer, including mesothelioma. Recently, the combination of autologous tumor lysate-pulsed dendritic cells (DC) and metronomic cyclophosphamide (
Lisanne Noordam, Margaretha E.H. Kaijen, Koen Bezemer, Robin Cornelissen, Lex A.P.W.M. Maat, Henk C. Hoogsteden, Joachim G.J.V. Aerts, Rudi W. Hendriks, Joost P.J.J Hegmans, Heleen Vroman   +9 more
doaj   +1 more source