Results 21 to 30 of about 520,917 (199)

Effect of arthritic synovial fluids on the expression of immunomodulatory factors by mesenchymal stem cells: an explorative in-vitro study

Frontiers in Immunology, 2012
Background: In diseased joints, the catabolic environment results in progressive joint damage. Mesenchymal stem cells (MSCs) can have immunomodulatory effect by secreting anti-inflammatory factors. To exert these effects, MSCs need to be triggered by pro-
Maarten J.C. Leijs, Gerben M. Van Buul, Gerben M. Van Buul, Erik eLubberts, Pieter K. Bos, Jan A.N. Verhaar, Martin J. Hoogduijn, Gerjo J.V.M. van Osch, Gerjo J.V.M. van Osch   +8 more
doaj   +1 more source

Bone Mineral Density After Contemporary Treatment for Acute Lymphoblastic Leukaemia: A Matched Cross‐Sectional Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Reduced bone mineral density (BMD) has been reported in survivors of childhood and young adult acute lymphoblastic leukaemia (ALL); however, data from cohorts treated with contemporary protocols and including matched controls remain limited.
Karen Schow Jensen, Mette Tiedemann Skipper, Niels Holtum Birkebæk, Kjeld Schmiegelow, Thomas Leth Frandsen, Bente Langdahl, Rikke Beck Jensen, Asger Roer Pedersen, Christian Mølgaard, Liv Andrés‐Jensen, Birgitte Klug Albertsen   +10 more
wiley   +1 more source

Anatomical pathways involved in generating and sensing rhythmic whisker movements

Frontiers in Integrative Neuroscience, 2011
The rodent whisker system is widely used as a model system for investigating sensorimotor integration, neural mechanisms of complex cognitive tasks, neural development, and robotics.
Laurens W.J. Bosman, Laurens W.J. Bosman, Arthur R. Houweling, Cullen B. Owens, Nouk eTanke, Olesya T. Shevchouk, Negah eRahmati, Wouter H.T. Teunissen, Chiheng eJu, Wei eGong, Sebastiaan K.E. Koekkoek, Chris I De Zeeuw, Chris I De Zeeuw   +12 more
doaj   +1 more source

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

FEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace, Alyssa Borges, Charles Arnaud, Tove Karlsson, Nina K. Bröker, Stefanie Barbirz, Marta Bally   +6 more
wiley   +1 more source

Effects of Hypoxia on the Immunomodulatory properties of Adipose tissue-derived Mesenchymal Stem Cells

Frontiers in Immunology, 2013
Adipose tissue-derived mesenchymal stem cells (ASC) are of great interest as a cellular therapeutic agent for regenerative and immunomodulatory purposes. The function of ASC adapts to environmental conditions, such as oxygen tension. Oxygen levels within
M eRoemeling-Van Rhijn, F KF Mensah, S S Korevaar, M JC Leijs, G JVM van Osch, J NM IJzermans, M GH Betjes, C C Baan, W eWeimar, M J Hoogduijn   +9 more
doaj   +1 more source

Smaller is better: nanobodies meet NMR

FEBS Letters, EarlyView.
Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley   +1 more source

Evolución temporal de la incidencia por incapacidad temporal de origen común según tramos de duración (2009-2018)

Archivos de Prevención de Riesgos Laborales, 2020
Objetivo: Describir la evolución temporal (2009-2018) de la incidencia de la incapacidad temporal por contingencia común (ITCC) según tramos de duración en España.
Mónica Ballesteros Polo, Maite Sampere Valero, Juan Carlos López López, Rosa Sacristán Nieto, Ana Ruiz Julián, Sara Alguacil García, Elisabeth Santos Ávila, Silvia García Rubia, Bibiana López Costa, José Miguel Martínez Martínez   +9 more
doaj   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Low-dose cyclophosphamide depletes circulating naïve and activated regulatory T cells in malignant pleural mesothelioma patients synergistically treated with dendritic cell-based immunotherapy

OncoImmunology, 2018
Rationale: Regulatory T cells (Treg) play a pivotal role in the immunosuppressive tumor micro-environment in cancer, including mesothelioma. Recently, the combination of autologous tumor lysate-pulsed dendritic cells (DC) and metronomic cyclophosphamide (
Lisanne Noordam, Margaretha E.H. Kaijen, Koen Bezemer, Robin Cornelissen, Lex A.P.W.M. Maat, Henk C. Hoogsteden, Joachim G.J.V. Aerts, Rudi W. Hendriks, Joost P.J.J Hegmans, Heleen Vroman   +9 more
doaj   +1 more source

Granuloma formation in pulmonary sarcoidosis

Frontiers in Immunology, 2013
Sarcoidosis is a granulomatous disorder of unknown cause, affecting multiple organs, but mainly the lungs. The exact order of immunological events remains obscure.
Caroline E. Broos, Menno evan Nimwegen, Henk C. Hoogsteden, Rudi W. Hendriks, Mirjam eKool, Bernt evan den Blink   +5 more
doaj   +1 more source