Results 41 to 50 of about 11,016 (204)

Differential Signaling Profiles of MC4R Mutations with Three Different Ligands [PDF]

International Journal of Molecular Sciences, 2020
The melanocortin 4 receptor (MC4R) is a key player in hypothalamic weight regulation and energy expenditure as part of the leptin–melanocortin pathway. Mutations in this G protein coupled receptor (GPCR) are the most common cause for monogenetic obesity, which appears to be mediated by changes in the anorectic action of MC4R via GS-dependent cyclic ...
Sarah Paisdzior, Ioanna Maria Dimitriou, Paul Curtis Schöpe, Paolo Annibale, Patrick Scheerer, Heiko Krude, Martin J. Lohse, Heike Biebermann, Peter Kühnen   +8 more
openaire   +7 more sources

Folding, misfolding, and regulation of intracellular traffic of G protein‐coupled receptors involved in the hypothalamic–pituitary–gonadal axis

Andrology, EarlyView.
Abstract Background G protein‐coupled receptors are a large and functionally diverse family of membrane receptors involved in a number of biological processes. Like other proteins, G protein‐coupled receptors need to be properly folded in order to traffic to the plasma membrane and interact with agonist.
Alfredo Ulloa‐Aguirre, Ross C. Anderson, Teresa Zariñán, Rubén Gutiérrez‐Sagal, Eduardo Jardón‐Valadez, Claire L. Newton   +5 more
wiley   +1 more source

Activation of melanocortin receptor 4 with RO27-3225 attenuates neuroinflammation through AMPK/JNK/p38 MAPK pathway after intracerebral hemorrhage in mice

Journal of Neuroinflammation, 2018
Background Neuroinflammation plays an important role in the pathogenesis of intracerebral hemorrhage (ICH)-induced secondary brain injury. Activation of melanocortin receptor 4 (MC4R) has been shown to elicit anti-inflammatory effects in many diseases ...
Shengpan Chen, Lianhua Zhao, Prativa Sherchan, Yan Ding, Jing Yu, Derek Nowrangi, Jiping Tang, Ying Xia, John H. Zhang   +8 more
doaj   +1 more source

Precision nutrition in weight loss and neuroendocrine control of people with obesity: The study protocol of a factorial randomised controlled trial (GenON Programme)

Diabetes, Obesity and Metabolism, EarlyView.
Abstract Aims Precision nutrition, guided by genetic testing, has emerged as a promising approach for managing obesity. However, robust clinical trials testing its effectiveness in real‐world dietary interventions remain scarce. The GenOn Programme aims to evaluate whether tailoring nutritional care based on genetic risk for obesity enhances weight ...
Karla P. Balbino, Ana Claudia P. Kravchychyn, Flávia G. Cândido, Mariana de Moura e Dias, Tiago Antônio de O. Mendes, Leandro Licursi de Oliveira, Luiza Carla V. Castro, Josefina Bressan, Ana Laura de la Garza, Fermín I. Milagro, María A. Zulet, Helen Hermana M. Hermsdorff   +11 more
wiley   +1 more source

Tonic ubiquitination of the central body weight regulator melanocortin receptor 4 (MC4R) promotes its constitutive exit from cilia.

PLoS Biology
The G protein-coupled receptor (GPCR) melanocortin receptor 4 (MC4R) is an essential regulator of body weight homeostasis. MC4R is unusual among GPCRs in that its activity is regulated by 2 opposing physiological ligands, the agonist ⍺-MSH and the ...
Irene Ojeda-Naharros, Tirthasree Das, Ralph A Castro, J Fernando Bazan, Christian Vaisse, Maxence V Nachury   +5 more
doaj   +1 more source

A multi‐omics investigation of sarcopenia and frailty: Integrating genomic, epigenomic and telomere length data

Experimental Physiology, EarlyView.
Abstract Sarcopenia and frailty are complex geriatric syndromes influenced by a combination of genetic and environmental factors. Recent studies suggest that specific genetic variants, DNA methylation patterns and shortened telomeres are associated with age‐related diseases and might contribute to the development of both sarcopenia and frailty. In this
Valentina Ginevičienė, Erinija Pranckevičienė, Alina Urnikytė, Laura Jurkūnaitė, Kristijona Gutauskaitė, Rūta Dadelienė, Justina Kilaitė, Ieva Eglė Jamontaitė, Asta Mastavičiūtė, Ildus I. Ahmetov, Vidmantas Alekna   +10 more
wiley   +1 more source

Cloning, distribution, and effects of growth regulation of MC3R and MC4R in red crucian carp (Carassius auratus red var.)

Frontiers in Endocrinology
BackgroundMelanocortin-3 and -4 receptors (MC3R and MC4R), G protein-coupled receptors, play vital roles in the regulation of energy homeostasis. To understand the functions of mc3r and mc4r in the energy homeostasis of red crucian carp (Carassius ...
Lu Huang, Xin Deng, Xiangqiong Yang, Zhong Tang, Siyu Fan, Zhifeng Zhou, Min Tao, Shaojun Liu   +7 more
doaj   +1 more source

Investigation of a genome wide association signal for obesity: synthetic association and haplotype analyses at the melanocortin 4 receptor gene locus. [PDF]

PLoS ONE, 2010
BACKGROUND: Independent genome-wide association studies (GWAS) showed an obesogenic effect of two single nucleotide polymorphisms (SNP; rs12970134 and rs17782313) more than 150 kb downstream of the melanocortin 4 receptor gene (MC4R).
André Scherag, Ivonne Jarick, Jessica Grothe, Heike Biebermann, Susann Scherag, Anna-Lena Volckmar, Carla Ivane Ganz Vogel, Brandon Greene, Johannes Hebebrand, Anke Hinney   +9 more
doaj   +1 more source

Role of Acid‐Sensing Ion Channels 1a in the Regulation of Obesity and the Gut Microbiota

Obesity, Volume 34, Issue 2, Page 372-381, February 2026.
ABSTRACT Objective Acid‐sensing ion channels are proton‐activated ion channels predominantly found in the nervous system. They are well known to affect metabolic and neurological health, yet their role in obesity and gut physiology remains unclear. This study investigates how systemic deletion of Asic1a influences obesity, metabolic, and gut‐based ...
Jane Shearer, Morris H. Scantlebury, Oghenefejiro Erome‐Utunedi, Anamika Choudhary, Jennifer A. Thompson, Christina Ohland, Kathy D. McCoy, Chunlong Mu   +7 more
wiley   +1 more source

Associations of MC4R, LEP, and LEPR Polymorphisms with Obesity-Related Parameters in Childhood and Adulthood [PDF]

, 2021
Asta Raskilienė, Alina Smalinskienė, Vilma Kriaučionienė, Vaiva Lesauskaitė, Janina Petkevičienė   +4 more
openalex   +1 more source