Severe Atherosclerosis and Hypercholesterolemia in Mice Lacking Both the Melanocortin Type 4 Receptor and Low Density Lipoprotein Receptor. [PDF]
PLoS ONE, 2016 Dysfunction of the melanocortin system can result in severe obesity accompanied with dyslipidemia and symptoms of the metabolic syndrome but the effect on vascular atherogenesis is not known.
Vera Lede +9 more
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Altered hepatic lipid metabolism in mice lacking both the melanocortin type 4 receptor and low density lipoprotein receptor. [PDF]
PLoS ONE, 2017 Obesity is often associated with dyslipidemia and hepatosteatosis. A number of animal models of non-alcoholic fatty liver disease (NAFLD) are established but they significantly differ in the molecular and biochemical changes depending on the genetic ...
Vera Lede +11 more
doaj +4 more sources
Jurnal Medik Veteriner, 2023 Etawah crossbreed and Senduro goats as superior local goats and biological genetic resources that must be preserved in Indonesia. Melanocortin receptor type 4 (MC4R) is the primary gene that regulates food intake and energy balance which can be used as a
Ristaqul Husna Belgania +4 more
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Association of central α-klotho with dopaminergic and melanocortin receptors on feed intake regulation in chicken [PDF]
Poultry ScienceThis study aimed to detemine association of central α-klotho with dopaminergic and melanocortin receptors on feed intake regulation in chicken. 264 meat-type chicken were included 6 experiments, each containing 4 groups.
Yaser Hassania +3 more
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-related monogenic obesity in children: insights from 2 cases [PDF]
Annals of Pediatric Endocrinology & MetabolismChildhood and adolescent obesity are growing global health concerns, with genetic factors playing an important role. Despite the increasing prevalence of obesity in India, monogenic obesity remains underdiagnosed.
Dhivya Shanmugam +5 more
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GLP-1 Receptor Agonist Treatment in Morbid Obesity and Type 2 Diabetes Due to Pathogenic Homozygous Melanocortin-4 Receptor Mutation: A Case Report [PDF]
Cell Reports Medicine, 2020 Summary: Individuals with obesity due to pathogenic heterozygous melanocortin 4 receptor (MC4R) mutations can be treated efficiently with the glucagon-like peptide-1 receptor agonist (GLP-1 RA) liraglutide.
Eva W. Iepsen +10 more
doaj +6 more sources
Nesfatin-1 Suppresses Cardiac L-type Ca2+ Channels Through Melanocortin Type 4 Receptor and the Novel Protein Kinase C Theta Isoform Pathway [PDF]
Cellular Physiology and Biochemistry, 2015 Background/Aims: Nesfatin-1 (NF-1), an anorexic nucleobindin-2 (NUCB2)-derived hypothalamic peptide, acts as a peripheral cardiac modulator and it can induce negative inotropic effects.
Jiaoqian Ying +7 more
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The effect of human wharton’s jelly-derived mesenchymal stem cells on MC4R, NPY, and LEPR gene expression levels in rats with streptozotocin-induced diabetes [PDF]
Iranian Journal of Basic Medical Sciences, 2020 Objective(s): Type 1 diabetes (T1D) is an autoimmune disease resulting from inflammatory destruction of islets β-cells. Nowadays, progress in cell therapy, especially mesenchymal stem cells (MSCs) proposes numerous potential remedies for T1D. We aimed to
Fatemeh Sabet Sarvestani +5 more
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The melanocortin pathway and energy homeostasis: From discovery to obesity therapy
Molecular Metabolism, 2021 Background: Over the past 20 years, insights from human and mouse genetics have illuminated the central role of the brain leptin-melanocortin pathway in controlling mammalian food intake, with genetic disruption resulting in extreme obesity, and more ...
Giles S.H. Yeo +14 more
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Biology, 2022 As a member of the melanocortin receptor family, melanocortin 4 receptor (MC4R) plays a critical role in regulating energy homeostasis and feeding behavior, and has been proven as a promising therapeutic target for treating severe obesity syndrome ...
Jing Xu +8 more
doaj +1 more source