Results 1 to 10 of about 10,269 (135)

A Setmelanotide-like Effect at MC4R Is Achieved by MC4R Dimer Separation

Biomolecules, 2022
Melanocortin 4 receptor (MC4R) is part of the leptin-melanocortin pathway and plays an essential role in mediating energy homeostasis. Mutations in the MC4R are the most frequent monogenic cause for obesity.
Patrick Scheerer, Sarah Paisdzior, Heike Biebermann   +2 more
exaly   +3 more sources

Analysis of the Role of the Mc4r System in Development, Growth, and Puberty of Medaka

Frontiers in Endocrinology, 2019
In mammals the melanocortin 4 receptor (Mc4r) signaling system has been mainly associated with the regulation of appetite and energy homeostasis. In fish of the genus Xiphophorus (platyfish and swordtails) puberty onset is genetically determined by a ...
Manfred Schartl, Mateus Adolfi, Masato Kinoshita   +2 more
exaly   +3 more sources

Electroacupuncture alleviates blood-brain barrier disruption and neuroinflammation via astrocytic MC4R in a mouse model of multiple sclerosis [PDF]

Journal of Neuroinflammation
Astrocytes are key regulators of neuroinflammation in multiple sclerosis (MS). Electroacupuncture (EA), a safe and cost-effective adjuvant therapy, has shown benefits in neurodegenerative diseases, but its astrocyte-related mechanisms remain unclear ...
Yanping Wang, Xiaoru Ma, Zhixin Qiao, Xiyu Zhang, Jiayu Ji, Sifan Zhang, Wei Zhuang, Junfeng Wu, Anqi Li, Chao Wang, Xin Xiu, Jing Wang, Yanting Meng, Wei Huang, Xiujuan Lang, Xijun Liu, Bo Sun, Hulun Li, Yumei Liu   +18 more
doaj   +2 more sources

Descriptive analysis of MC4R gene variants associated with obesity listed on ClinVar

Science Progress
Objectives The most recent version of ClinVar was utilized to filter variants of the MC4R gene based on location, condition, and clinical significance with the goal of obtaining benign and disease-associated variants of the MC4R gene.
, Zubair Karim
exaly   +2 more sources

Melanocortin-4 receptor in macrophages attenuated angiotensin II-induced abdominal aortic aneurysm in mice

Scientific Reports, 2023
Obesity is recognized as an independent risk factor for abdominal aortic aneurysm (AAA). While mutations in the melanocortin-4 receptor (MC4R) gene is the most common cause of obesity caused by mutations in a single gene, the link between MC4R function ...
Kentaro Mori, Hideyuki Okuma, Suguru Nakamura, Hiroyuki Uchinuma, Shigeaki Kaga, Hiroyuki Nakajima, Yoshihiro Ogawa, Kyoichiro Tsuchiya   +7 more
doaj   +1 more source

Association of the AspP298Asn polymorphism in the MC4R gene with fattening productivity of immunologically castrated and uncastrated gilts

Біологія тварин, 2023
The study was aimed at establishing the presence of MC4R (c.1426 A>G) gene polymorphism among the population of immunologically castrated and native gilts (Large White × Landrace) × Maxgro.
Y. Pocherniaieva, K. Pochernyayev, I. Bankovska   +2 more
doaj   +1 more source

The Mc4r gene is responsible for the development of experimentally induced testicular teratomas

Scientific Reports, 2023
Teratomas in mice, composed of different tissue types, are derived from primordial germ cells in the fetal gonads. Previously, we identified a locus responsible for experimental testicular teratoma (ETT) formation on chromosome 18, referred to as ett1 ...
Syunsuke Seki, Kaoru Ohura, Takehiro Miyazaki, Abdullah An Naser, Shuji Takabayashi, Eisei Tsutsumi, Toshinobu Tokumoto   +6 more
doaj   +1 more source

Genetic structure and population dynamics of autochthonous and modern porcine breeds. Analysis of the IGF2 and MC4R genes that determine carcass characteristics

Austral Journal of Veterinary Sciences, 2020
To know the genetic situation of the Pampa Rocha, Celta, Bizaro Portuguese, Duroc, Iberian Extremeño and Iberian Andalusian porcine populations, their genetic structure and population dynamics were studied on the IGF2 and MC4R genes, which determine meat
Silvia Llambí, María Montenegro, Rosa Gagliardi, Carmen Burgos, Jorge Hidalgo, Pascual López-Buesa, María V. Arruga   +6 more
doaj   +1 more source

MRAP2 Interaction with Melanocortin-4 Receptor in SnakeHead (Channa argus)

Biomolecules, 2021
The melanocortin-4 receptor (MC4R) plays an important role in the regulation of food intake and energy expenditure. Melanocortin-2 receptor accessory protein 2 (MRAP2) modulates trafficking, ligand binding, and signaling of MC4R.
Zheng-Yong Wen, Ting Liu, Chuan-Jie Qin, Yuan-Chao Zou, Jun Wang, Rui Li, Ya-Xiong Tao   +6 more
doaj   +1 more source

Human MC4R variants affect endocytosis, trafficking and dimerization revealing multiple cellular mechanisms involved in weight regulation

Cell Reports, 2021
Summary: The Melanocortin-4 Receptor (MC4R) plays a pivotal role in energy homeostasis. We used human MC4R mutations associated with an increased or decreased risk of obesity to dissect mechanisms that regulate MC4R function.
Bas Brouwers, Edson Mendes de Oliveira, Maria Marti-Solano, Fabiola B.F. Monteiro, Suli-Anne Laurin, Julia M. Keogh, Elana Henning, Rebecca Bounds, Carole A. Daly, Shane Houston, Vikram Ayinampudi, Natalia Wasiluk, David Clarke, Bianca Plouffe, Michel Bouvier, M. Madan Babu, I. Sadaf Farooqi, Jacek Mokrosiński   +17 more
doaj   +1 more source