Results 1 to 10 of about 162,838 (148)
Anti-Melanocortin-4 Receptor Autoantibodies in Obesity [PDF]
The Journal of Clinical Endocrinology & Metabolism, 2009 The melanocortin-4 receptor (MC4R) is part of an important pathway regulating energy balance. Here we report the existence of autoantibodies (autoAbs) against the MC4R in sera of obese patients.The autoAbs were detected after screening of 216 patients' sera by using direct and inhibition ELISA with an N-terminal sequence of the MC4R.
Peter, J. C. +9 more
openaire +7 more sources
Evolutionary Aspects in Evaluating Mutations in the Melanocortin 4 Receptor [PDF]
Endocrinology, 2007 More than 70 missense mutations have been identified in the human melanocortin 4 receptor (MC4R), and many of them have been associated with obesity. In a number of cases, the causal link between mutations in MC4R and obesity is controversially discussed.
Stäubert, Claudia +8 more
openaire +7 more sources
Melanocortin-4 Receptor in Fish: A Review [PDF]
International Journal of Agricultural Science and Food Technology, 2017 The melanocortin-4 receptor (MC4R) belongs to the melanocortin system, has been well investigated in mammals. Which plays important roles in several physiological processes, such as regulating energy homeostasis, cachexia, cardiovascular function, glucose and lipid homeostasis, reproduction and sexual function, drug abuse, pain perception, brain ...
Zheng-Yong Wen +5 more
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Functional Role, Structure, and Evolution of the Melanocortin‐4 Receptor [PDF]
Annals of the New York Academy of Sciences, 2003 Abstract: The melanocortin (MC)‐4 receptor participates in regulating body weight homeostasis. We demonstrated early that acute blockage of the MC‐4 receptor increases food intake and relieves anorexic conditions in rats. Our recent studies show that 4‐week chronic blockage of the MC‐4 receptor leads to robust increases in food intake and development ...
HB Schioth +9 more
openaire +3 more sources
On the Molecular Pharmacology of the Melanocortin-4 Receptor [PDF]
, 2003 Melanocortin hormones, like alpha-MSH and ACTH (melanocyte stimulating hormone and adrenocorticotropic hormone), regulate several biological processes, including bodyweight homeostasis, neuropathic pain and nerve regeneration after nerve damage. Five melanocortin receptor subtypes have been cloned, which transduce the hormone signals via G-proteins to ...
Nijenhuis, Wouter Albertus Johannes
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Motivational Dysregulation with Melanocortin 4 Receptor Haploinsufficiency
NeuroImmune Pharmacology and Therapeutics, 2022 Abstract Obesity, by any standard, is a global health crisis. Both genetic and dietary contributions to the development and maintenance of obesity were integral factors of our experimental design. As mutations of the melanocortin 4 receptors (MC4R) are the leading monogenetic cause of obesity, MC4R haploinsufficient rats were fed a ...
Steiner, Alex M. +3 more
openaire +2 more sources
Melanocortin 4 receptor distribution in the human hypothalamus [PDF]
European Journal of Endocrinology, 2013 ObjectiveThe melanocortin 4 receptor (MC4R) is an essential regulator of energy homeostasis and metabolism, andMC4Rmutations represent the most prevalent monogenetic cause of obesity in humans known to date. Hypothalamic MC4Rs in rodents are well characterized in neuroanatomical and functional terms, but their expression pattern in the human ...
Siljee, J.E. +5 more
openaire +6 more sources
Melanocortin-4 Receptors (MC4R)
AVERROUS: Jurnal Kedokteran dan Kesehatan Malikussaleh, 2023 Melanocortin 4 Receptors (MC4R) merupakan turunan senyawa G protein coupled-receptors (GPCRs). MC4R berperan dalam homeostasis energi, fungsi kardiovaskular, dan sistem reproduksi. Gen MC4R ini menyandi sekitar 332 asam amino dan terkespresi pada hipotalamus. MC4R salah satu protein transmembran dengan memiliki tujuh subtipe protein.
Liza Arieska Saiful, Nuraiza Meutia
openaire +1 more source
A role for the melanocortin 4 receptor in sexual function [PDF]
Proceedings of the National Academy of Sciences, 2002 By using a combination of genetic, pharmacological, and anatomical approaches, we show that the melanocortin 4 receptor (MC4R), implicated in the control of food intake and energy expenditure, also modulates erectile function and sexual behavior.
Lex H T, Van der Ploeg +33 more
openaire +2 more sources
Novel anti-inflammatory and chondroprotective effects of the human melanocortin MC1 receptor agonist BMS-470539 dihydrochloride and human melanocortin MC3 receptor agonist PG-990 on lipopolysaccharide activated chondrocytes [PDF]
, 2020 Human melanocortin MC1 and MC3 receptors expressed on C-20/A4 chondrocytes exhibit chondroprotective and anti-inflammatory effects when activated by melanocortin peptides.
De Pascale, C. +15 more
core +1 more source