Results 1 to 10 of about 60,342 (231)

The Melanocortin-4 Receptor: Physiology, Pharmacology, and Pathophysiology [PDF]

Endocrine Reviews, 2010
The melanocortin-4 receptor (MC4R) was cloned in 1993 by degenerate PCR; however, its function was unknown. Subsequent studies suggest that the MC4R might be involved in regulating energy homeostasis. This hypothesis was confirmed in 1997 by a series of seminal studies in mice. In 1998, human genetic studies demonstrated that mutations in the MC4R gene
Ya-Xiong Tao
openaire   +4 more sources

Understanding pseudo-albinism in sole (Solea senegalensis): a transcriptomics and metagenomics approach [PDF]

, 2019
Pseudo-albinism is a pigmentation disorder observed in flatfish aquaculture with a complex, multi-factor aetiology. We tested the hypothesis that pigmentation abnormalities are an overt signal of more generalised modifications in tissue structure and ...
Carballo, Carlos, Codoñer, Francisco M., Costa, Rita A., Guerreiro, Claudia, Manchado, Manuel, Martinez-Blanch, Juan F., Pinto, Patricia IS, Power, Deborah   +7 more
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The Obesogenic and Glycemic Effect of Bariatric Surgery in a Family with a Melanocortin 4 Receptor Loss-of-Function Mutation

Metabolites, 2022
We report the long-term response to bariatric surgery in a singular family of four adolescents with severe obesity (41–82 kg/m2), homozygous for the C271R loss-of-function mutation in the melanocortin 4 receptor (MC4R), and three adults heterozygous for ...
Ronit Grinbaum, Nahum Beglaibter, Stella Mitrani-Rosenbaum, Lee M. Kaplan, Danny Ben-Zvi   +4 more
doaj   +1 more source

Development of a genetically encoded melanocortin sensor for high sensitivity in vivo imaging

Molecular Metabolism
Objective: The central melanocortin system, composed of peptides derived from pro-opiomelanocortin (POMC) such as the melanocyte-stimulating hormones (α-, β-, γ-MSH) and melanocortin 4 receptors (MC4R), along with the agouti-related protein (AgRP), plays
Yoon Namkung, Tal Slutzki, Joao Pedroso, Xiaohong Liu, Paul V. Sabatini, Maia V. Kokoeva, Stéphane A. Laporte   +6 more
doaj   +1 more source

Development of the Hypothalamic Melanocortin System

Frontiers in Endocrinology, 2013
The melanocortin system is a critical component of the forebrain and hindbrain regulatory systems involved in energy balance. This system is composed of pro-opiomelanocortin (POMC) neurons that act, in part, through the melanocortin-4 receptor (MC4R ...
Berengere eCoupe, Sebastien G Bouret
doaj   +1 more source

Vagal Blocking for Obesity Control : a Possible Mechanism-Of-Action [PDF]

, 2016
14 September 2016 Erratum to: Vagal Blocking for Obesity Control: a Possible Mechanism-Of-Action Helene Johannessen, David Revesz, Yosuke Kodama, Nikki Cassie, Karolina P Skibicka, Perry Barrett, Suzanne Dickson, Jens Holst, Jens Rehfeld, Geoffrey van ...
Adan, Roger, Barrett, Perry, Ben-Menachem, Elinor, Cassie, Nikki, Chen, Duan, Dickson, Suzanne, Holst, Jens, Johannessen, Helene, Kodama, Yosuke, Kulseng, Bård, Rehfeld, Jens, Revesz, David, Skibicka, Karolina P, van der Plasse, Geoffrey, Zhao, Chun-Mei   +14 more
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Melanocortin-4 receptor activation promotes insulin-stimulated mTOR signaling [PDF]

Peptides, 2010
The melanocortin signaling system is integral in regulating energy homeostasis. The melanocortin-4 receptor (MC4R) activates several signaling pathways in performance of this function. The effect of MC4R on insulin-stimulated mammalian target of rapamycin (mTOR), a cellular energy sensor, signaling was investigated.
Biaoxin, Chai, Ji-Yao, Li, Weizhen, Zhang, Xiaobin, Wu, Chao, Zhang, Michael W, Mulholland   +5 more
openaire   +2 more sources

Inter-individual variability amplified through breeding reveals control of reward-related action strategies by Melanocortin-4 Receptor in the dorsomedial striatum

Communications Biology, 2022
To uncover mechanisms underlying reward-seeking behaviours, Allen et al. employ a task in which mice must arbitrate between rewarded and nonrewarded behaviors.
Aylet T. Allen, Elizabeth C. Heaton, Lauren P. Shapiro, Laura M. Butkovich, Sophie T. Yount, Rachel A. Davies, Dan C. Li, Andrew M. Swanson, Shannon L. Gourley   +8 more
doaj   +1 more source

The role of hypothalamus-pituitary-adrenal (HPA)-like axis in inflammatory pilosebaceous disorders [PDF]

, 2020
Skin is the largest peripheral endocrine organ and functions as a hormone target and endocrine gland. A cutaneous hypothalamus-pituitary-adrenal (HPA)-like axis enables the skin to respond to stress and regulates its steroidogenic activity.
Clark, Ashley K, Saric-Bosanac, Suzana, Shi, Vivian Y, Sivamani, Raja K   +3 more
core  

Activation of Ventral Tegmental Area 5-HT2C Receptors Reduces Incentive Motivation [PDF]

, 2016
FUNDING AND DISCLOSURE The research was funded by Wellcome Trust (WT098012) to LKH; and National Institute of Health (DK056731) and the Marilyn H. Vincent Foundation to MGM.
AH Rezvani, AJ Hill, B Doslikova, C Harvey-Lewis, C Miguelez, CD Wynne, Christopher M Bradshaw, CK Martin, CM Bradshaw, CM Olarte-Sanchez, CM Olarte-Sanchez, CM Olarte-Sanchez, Cristian M Olarte-Sánchez, David J Lyons, DD Lam, DJ Hayes, DJ Urban, ED Levin, G Bezzina, G Paxinos, GA Higgins, GM Alexander, GS Kranz, HY Meltzer, JC Halford, JD Salamone, JE Aberman, JE Blundell, L Valencia-Torres, LK Burke, LK Burke, LK Burke, LK Heisler, Lora K Heisler, Lourdes Valencia-Torres, M Filip, Martin G Myers, Megan Greenwald-Yarnell, MJ Bubar, MJ Bubar, NR Richardson, P Skjoldager, PJ Fletcher, PJ Fletcher, PR Killeen, PR Killeen, RJ DiLeone, S Burbassi, S Higgs, SM Graves, SP Vickers, Teodora Georgescu, V Di Matteo, W Hodos, WJ Thomsen, Y Xu   +55 more
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