Results 31 to 40 of about 162,838 (148)

Targeting the melanocortin receptor system for anti-stroke therapy [PDF]

, 2011
The melanocortin receptors are a subfamily of G-protein-coupled, rhodopsin-like receptors that are rapidly being acknowledged as an extremely promising target for pharmacological intervention in a variety of different inflammatory pathologies, including ...
Smith, H.K., Gavins, F.N.E., Holloway, P.M., Renshaw, D., Flower, R.J., Getting, S.J.   +5 more
core   +1 more source

Agouti protein, mahogunin, and attractin in pheomelanogenesis and melanoblast-like alteration of melanocytes: a cAMP-independent pathway [PDF]

, 2009
Melanocortin-1 receptor (MC1R) and its ligands, a-melanocyte stimulating hormone (aMSH) and agouti signaling protein (ASIP), regulate switching between eumelanin and pheomelanin synthesis in melanocytes.
Bennett, DC, Jimbow, K, Wakamatsu, Kazumasa, Elena V. Sviderskaya, Shosuke Ito, Montoliu, L, Andrew J. Donkin, Tokimasa Hida, Yu, B, Bin Yu, Lluis Montoliu, Donkin, AJ, Wakamatsu, K, Dorothy C. Bennett, Hida, T, Yu, Bin, Millhauser, Glenn L., Bennett, Dorothy C., Barsh, GS, Sviderskaya, Elena V., Sviderskaya, EV, Ito, Shosuke, Lamoreux, ML, Kazumasa Wakamatsu, M. Lynn Lamoreux, Glenn L. Millhauser, Kowichi Jimbow, Lynn Lamoreux, M, Donkin, Andrew J., Lamoreux, M. Lynn, Hida, Tokimasa, Montoliu, Lluís, Gregory S. Barsh, Millhauser, GL, Barsh, Gregory S., Ito, S, Jimbow, Kowichi   +36 more
core   +1 more source

Melanocortin 4 receptor mutation in obesity

World Journal of Experimental Medicine
Obesity is increasingly prevalent worldwide, with genetic factors contributing to its development. The hypothalamic leptin-melanocortin pathway is central to the regulation of appetite and weight; leptin activates the proopiomelanocortin neurons, leading to the production of melanocortin peptides; these in turn act on melanocortin 4 receptors (MC4R ...
Sridhar, Gumpeny R, Gumpeny, Lakshmi
openaire   +2 more sources

A neural basis for melanocortin-4 receptor–regulated appetite [PDF]

Nature Neuroscience, 2015
Pro-opiomelanocortin (POMC)- and agouti-related peptide (AgRP)-expressing neurons of the arcuate nucleus of the hypothalamus (ARC) are oppositely regulated by caloric depletion and coordinately stimulate and inhibit homeostatic satiety, respectively. This bimodality is principally underscored by the antagonistic actions of these ligands at downstream ...
Garfield, Alastair S., Madara, Joseph, Campbell, John, Olson, David, Tannous, Bakhos, Lowell, Bradford, Li, Chia, Shah, Bhavik P., Webber, Emily, Steger, Jennifer S., Gavrilova, Oksana, Lee, Charlotte E., Elmquist, Joel K., Krashes, Michael J.   +13 more
openaire   +4 more sources

Health‐Related Quality of Life, Everyday Executive Functioning, and Eating Behavior in Adults With Bardet–Biedl Syndrome

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Bardet–Biedl syndrome (BBS) is a rare genetic condition with a broad phenotypic spectrum. Knowledge about quality of life, executive functioning, and eating behavior in adults with BBS remains limited. This study aimed to assess health‐related quality of life (HRQoL), everyday executive functioning, and eating behavior in adults with BBS and ...
Cecilie Fremstad Rustad, Charlotte von der Lippe, Hilde Nordgarden, Jeanette Ullmann Miller, Mina Susanne Weedon‐Fekjær, Ragnheidur Bragadottir, Solrun Sigurdardottir   +6 more
wiley   +1 more source

The role of pituitary melanocortin receptor 3 (MC3) in regulation of hormone output [PDF]

, 2022
Introduction/Aim: Of the five melanocortin receptors (MCs: MC1-5) identified to date, the focus of neuroendocrine studies has principally been on MC3 and MC4 due to their role in regulating body weight: a role presumed to be mediated by hypothalamic ...
Murray, J.F., Smith, C.L., Laiho, L, Le Tissier, P., Dowejko, M.M., Berruien, N., Fiordelisio, T, Santiago Andres, Y, Andoniadou, C   +8 more
core  

Streamlining Diagnosis of Bardet–Biedl Syndrome: New Diagnostic Algorithm With Updated Criteria

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Considerable advances have been made in our understanding of Bardet–Biedl syndrome (BBS), particularly in its core clinical features and molecular genetics, warranting an update to the existing diagnostic criteria framework. Using a rigorous, evidence‐based, and consensus‐driven process, a multidisciplinary group of international experts and ...
Jeremy J. Pomeroy, Jesse Richards, Brooke R. Sweeney, Seema Kumar, Katie E. Queen, Joshua Zaritsky, Carl H. Cramer, Elias I. Traboulsi, Brittni A. Scruggs, Erica E. Davis, Ekaterina Keifer, Emma McGibbon, Timothy Ogden, Bendert De Graaf, Tonia Hymers, Elizabeth Forsythe, Philip Beales   +16 more
wiley   +1 more source

Melanocortin MC₄ receptor expression sites and local function [PDF]

, 2011
The melanocortin MC(4) receptor plays an important role in energy metabolism, but also affects blood pressure, heart rate and erectile function. Localization of the receptors that fulfill these distinct roles is only partially known.
Jacqueline E. Siljee-Wong, Siljee-Wong, Jacqueline E.   +1 more
core   +1 more source

Genetic Diversity, Adaptation, Wild Introgression, and Coat Color Mutation of Golden Yak

Animal Research and One Health, EarlyView.
Genetic diversity, adaptation, wild introgression, and coat color mutation of golden yak from two populations on the Qinghai‐Xizang Plateau. ABSTRACT The golden yak lives on the Qinghai‐Xizang Plateau with a golden coat and adapts to high altitudes and strong ultraviolet environment. The golden coat is a prominent phenotype in many domesticated species,
Huixuan Yan, Jialei Chen, Chuzhao Lei, Fengwei Zhang, Shunzhong He, Weiru Song, Hongyan Ma, Shuling Li, Guomei Li, Laba Yongcuo, Jianlin Han, Johannes A. Lenstra, Qiang Zhang, Rende Song, Basang Wangdui, Ningbo Chen   +15 more
wiley   +1 more source

Vascular effects of deletion of melanocortin-4 receptors in rats [PDF]

Physiological Reports, 2013
Obesity is a major cause of hypertension, but links between the obese and hypertensive states remain incompletely understood. A major component of cardiovascular function in obese individuals is a state of sympathoactivation. A postulated mechanism of this sympathoactivation is the activation of specific classes of neurons commonly associated with ...
Stepp, David W, Osakwe, Christabell C, de Chantemele, Eric J Belin, Mintz, James D   +3 more
openaire   +2 more sources