The melanocortin receptors and their accessory proteins. [PDF]
, 2013 The five melanocortin receptors (MCRs) named MC1R-MC5R have diverse physiological roles encompassing pigmentation, steroidogenesis, energy homeostasis and feeding behavior as well as exocrine function.
Adrian J. L. Clark +12 more
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Melanocortin-4 receptor regulation of pain
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 2017 An increasingly high occurrence of chronic pain in patients highlights the importance of fundamental research. The melanocortin-4 receptor (MC4R) regulation of pain has attracted much attention in recent years due to its high expression in the mammalian brain regions related to nociception and pain.
Zhi-Xiao, Li +3 more
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Melanocortin-4 receptor–regulated energy homeostasis [PDF]
Nature Neuroscience, 2016 The melanocortin system provides a conceptual blueprint for the central control of energetic state. Defined by four principal molecular components--two antagonistically acting ligands and two cognate receptors--this phylogenetically conserved system serves as a prototype for hierarchical energy balance regulation.
Michael J, Krashes +2 more
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Melanocortin-4 receptor gene: case-control study and transmission disequilibrium test confirm that functionally relevant mutations are compatible with a major gene effect for extreme obesity [PDF]
, 2003 We initially performed a mutation screen of the coding region of the MC4R in 808 extremely obese children and adolescents and 327 underweight or normal-weight controls allowing for a case-control study.
Sarah Hohmann +24 more
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Melanocortin 4 receptors switch reward to aversion [PDF]
Journal of Clinical Investigation, 2018 The ability to recognize and avoid noxious stimuli is essential for survival. The factors that determine whether a given stimulus is considered positive or negative are complex and not fully understood. In this issue of the JCI, Klawonn and colleagues demonstrate that melanocortin 4 receptor (MC4R) signaling is critical for proper responses to negative
Alexandra G, DiFeliceantonio +1 more
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Bioluminescence Resonance Energy Transfer Reveals the Adrenocorticotropin (ACTH)-Induced Conformational Change of the Activated ACTH Receptor Complex in Living Cells [PDF]
, 2011 Bioluminescence resonance energy transfer analysis is used to study the interaction between melanocortin 2 receptor (MC2R) accessory protein and the MC2R and provides evidence for protein kinase A-dependent conformational changes in the receptor complex ...
Adrian J. L. Clark +9 more
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A unique melanocortin-4-receptor signaling profile for obesity-associated constitutively active variants [PDF]
, 2023 The human melanocortin-4 receptor plays a critical role regulating energy homeostasis. Studies on obesogenic hMC4R variants have not yet revealed how human melanocortin-4 receptor maintains body weight.
Rikus Botha +7 more
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Localisation of the melanocortin-2-receptor and its accessory proteins in the developing and adult adrenal gland [PDF]
, 2011 The melanocortin-2-receptor (MC2R)/MC2R accessory protein (MRAP) complex is critical to the production of glucocorticoids from the adrenal cortex. Inactivating mutations in either MC2R or MRAP result in the clinical condition familial glucocorticoid ...
Leonardo Guasti +9 more
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MELANOCORTIN RECEPTOR ACCESSORY PROTEIN 2-INDUCED ADRENOCORTICOTROPIC HORMONE RESPONSE OF HUMAN MELANOCORTIN 4 RECEPTOR [PDF]
, 2018 Human (h) and zebrafish (zf) melanocortin receptor 4 (MC4R) activation data.Our data shows how both h and zfMC4R increase the sensitivity to the adrenocorticotropic hormone (ACTH) when interacting with the melanocortin receptor two accessory protein type
Cerda-Reverter, J
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The Asp84GIu variant of the melanocortin 1 receptor (MC1R)is associated with melanoma [PDF]
, 1996 Melanocyte stimulating hormone (MSH) plays an important role in determining the cutaneous response to ultraviolet radiation and may also influence melanoma progression.
Thody, Anthony J. +10 more
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