Results 11 to 20 of about 60,342 (231)

Motivational dysregulation with melanocortin 4 receptor haploinsufficiency. [PDF]

NeuroImmune Pharm Ther, 2022
AbstractObesity, by any standard, is a global health crisis. Both genetic and dietary contributions to the development and maintenance of obesity were integral factors of our experimental design. As mutations of the melanocortin 4 receptors (MC4R) are the leading monogenetic cause of obesity, MC4R haploinsufficient rats were fed a range of dietary fat (
Steiner AM, Roscoe RF, Booze RM, Mactutus CF.   +3 more
europepmc   +3 more sources

Melanocortin receptor accessory proteins in adrenal disease and obesity [PDF]

Frontiers in Neuroscience, 2015
Melanocortin receptor accessory proteins (MRAPs) are regulators of the melanocortin receptor family. MRAP is an essential accessory factor for the functional expression of the MC2R/ACTH receptor.
David eJackson, Shwetha eRamachandrappa, Adrian eClark, Li eChan   +3 more
doaj   +4 more sources

MRAP2 modifies the signaling and oligomerization state of the melanocortin-4 receptor [PDF]

Nature Communications
The melanocortin-4 receptor is a G protein-coupled receptor and a key regulator of appetite and metabolism. It can interact with the melanocortin-receptor accessory protein 2, a single transmembrane helix protein known to interact with several different ...
Iqra Sohail, Suli-Anne Laurin, Gunnar Kleinau, Vidicha Chunilal, Andrew Morton, Alfonso Brenlla, Zeynep Cansu Uretmen Kagiali, Marie-José Blouin, Javier A. Tello, Annette G. Beck-Sickinger, Martin J. Lohse, Patrick Scheerer, Michel Bouvier, Peter McCormick, Paolo Annibale, Heike Biebermann   +15 more
doaj   +2 more sources

Anti-melanocortin-4 receptor autoantibodies in obesity [PDF]

The Journal of Clinical Endocrinology & Metabolism, 2009
Background: The melanocortin-4 receptor (MC4R) is part of an important pathway regulating energy balance. Here we report the existence of autoantibodies (autoAbs) against the MC4R in sera of obese patients.
Bekel, A., Breidert, M., Eftekhari, P., Hofbauer, K. G., Kessler, L., Lecourt, A. C., Muller, S., Nesslinger, M., Peter, J. C., Zipfel, G.   +9 more
core   +8 more sources

Melanocortin 4 receptor mutation in obesity. [PDF]

World J Exp Med
Obesity is increasingly prevalent worldwide, with genetic factors contributing to its development. The hypothalamic leptin-melanocortin pathway is central to the regulation of appetite and weight; leptin activates the proopiomelanocortin neurons, leading to the production of melanocortin peptides; these in turn act on melanocortin 4 receptors (MC4R ...
Sridhar GR, Gumpeny L.
europepmc   +3 more sources

Dimerization of melanocortin 4 receptor controls puberty onset and body size polymorphism [PDF]

Frontiers in Endocrinology, 2023
Xiphophorus fish exhibit a clear phenotypic polymorphism in puberty onset and reproductive strategies of males. In X. nigrensis and X. multilineatus, puberty onset is genetically determined and linked to a melanocortin 4 receptor (Mc4r) polymorphism of ...
Ruiqi Liu, Ruiqi Liu, Mike Friedrich, Katherina Hemmen, Kerstin Jansen, Mateus C. Adolfi, Manfred Schartl, Manfred Schartl, Katrin G. Heinze   +8 more
doaj   +2 more sources

Astrocytes: New Targets of Melanocortin 4 Receptor Actions [PDF]

Journal of Molecular Endocrinology, 2013
Astrocytes exert a wide variety of functions with paramount importance in brain physiology. After injury or infection, astrocytes become reactive and they respond by producing a variety of inflammatory mediators that help maintain brain homeostasis. Loss
Carniglia, Lila, Caruso, Carla Mariana, Durand, Daniela Elizabeth, Lasaga, Mercedes Isabel, Scimonelli, Teresa Nieves   +4 more
core   +5 more sources

Ring finger protein 11 inhibits melanocortin 3 and 4 receptor signaling [PDF]

Frontiers in Endocrinology, 2016
Intact melanocortin signaling via the G protein-coupled receptors (GPCRs) melanocortin receptor 4 (MC4R) and melanocortin receptor 3 (MC3R) is crucial for body weight maintenance.
Anne Müller, Lars Niederstadt, Wenke Jonas, Wenke Jonas, Chun-Xia Yi, Franziska Meyer, Petra Wiedmer, Jana Fischer, Carsten Grötzinger, Annette Schürmann, Annette Schürmann, Matthias Tschöp, Matthias Tschöp, Gunnar Kleinau, Annette Grüters, Heiko Krude, Heike Biebermann   +16 more
doaj   +8 more sources

Evolutionary aspects in evaluating mutations in the melanocortin 4 receptor [PDF]

Endocrinology, 2007
More than 70 missense mutations have been identified in the human melanocortin 4 receptor (MC4R), and many of them have been associated with obesity. In a number of cases, the causal link between mutations in MC4R and obesity is controversially discussed.
Annette Grüters, Buono, Christian Pitra, Claudia Stäubert, Cone, Haitina, Harald Brumm, Heike Biebermann, Hinney, Holger Römpler, Huszar, Jacobson, Kim, Larsen, Lubrano-Berthelier, Mergen, Patrick Tarnow, Ringholm, Salomon, Sangkuhl, Schioth, Schoneberg, Schoneberg, Schulz, Talbot, Tao, Tao, Tarnow, Thomas Gudermann, Torsten Schöneberg, Vaisse, VanLeeuwen, Xiang, Yeo, Yeo   +34 more
core   +6 more sources

Structure elucidation of a human melanocortin-4 receptor specific orthosteric nanobody agonist [PDF]

Nature Communications
The melanocortin receptor 4 (MC4R) belongs to the melanocortin receptor family of G-protein coupled receptors and is a key switch in the leptin-melanocortin molecular axis that controls hunger and satiety.
Thomas Fontaine, Andreas Busch, Toon Laeremans, Stéphane De Cesco, Yi-Lynn Liang, Veli-Pekka Jaakola, Zara Sands, Sarah Triest, Simonas Masiulis, Lies Dekeyzer, Noor Samyn, Nicolas Loeys, Lisa Perneel, Melanie Debaere, Murielle Martini, Charlotte Vantieghem, Richa Virmani, Kamila Skieterska, Stephanie Staelens, Rosa Barroco, Maarten Van Roy, Christel Menet   +21 more
doaj   +2 more sources