Melanocortin receptor accessory proteins in adrenal disease and obesity [PDF]
This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the ...
Shwetha Ramachandrappa +11 more
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Emerging roles of melanocortin receptor accessory proteins (MRAP and MRAP2) in physiology and pathophysiology. [PDF]
Melanocortin-2 receptor accessory protein (MRAP) has an unusual dual topology and influences the expression, localisation, signalling and internalisation of the melanocortin receptor 2 (MC ); the adrenocorticotropic hormone (ACTH) receptor.
Smith, C.L., Berruien, N.
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Melanocortins and agouti-related protein modulate the excitability of two arcuate nucleus neuron populations by alteration of resting potassium conductances [PDF]
The hypothalamic melanocortin system is crucial for the control of appetite and body weight. Two of the five melanocortin receptors, MC3R and MC4R are involved in hypothalamic control of energy homeostasis, with the MC4R having the major influence. It is
Hisadome, Kazunari +11 more
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Astrocytes: new targets of melanocortin 4 receptor actions [PDF]
Astrocytes exert a wide variety of functions with paramount importance in brain physiology. After injury or infection, astrocytes become reactive and they respond by producing a variety of inflammatory mediators that help maintain brain homeostasis. Loss of astrocyte functions as well as their excessive activation can contribute to disease processes ...
Caruso, Carla Mariana +4 more
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Remapping the Synthetic Landscape of α‐Tertiary Alkylamines via Dual‐Functional Catechol
A three‐component assembly strategy has been developed for the modular synthesis of hindered α‐tertiary aliphatic amines from readily available precursors through unlocking the dual role of catechol. The practicality of this methodology has been demonstrated in over 90 examples, including compounds that are otherwise difficult to access, along with ...
Chen‐Yan Cai, Yuzuru Kanda, Tian Qin
wiley +2 more sources
Phenotypic characteristics of familial glucocorticoid deficiency (FGD) type 1 and 2 [PDF]
Context: Familial glucocorticoid deficiency (FGD) is a rare autosomal recessive disorder as a result of mutation in genes encoding either the ACTH receptor [melanocortin 2 receptor (MC2R)] or its accessory protein [melanocortin 2 receptor accessory ...
Metherell, LA +5 more
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The Melanocortin-4 Receptor: Physiology, Pharmacology, and Pathophysiology [PDF]
The melanocortin-4 receptor (MC4R) was cloned in 1993 by degenerate PCR; however, its function was unknown. Subsequent studies suggest that the MC4R might be involved in regulating energy homeostasis. This hypothesis was confirmed in 1997 by a series of seminal studies in mice. In 1998, human genetic studies demonstrated that mutations in the MC4R gene
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Neuroanatomy of melanocortin-4 receptor pathway in the mouse brain [PDF]
AbstractObjectiveMelanocortin-4 receptors (MC4Rs) are key regulators of energy homeostasis and adipose deposition in the central nervous system. Considering that MC4R expression regions and function-related research mainly focus on the paraventricular nucleus (PVN), little is known about their distribution throughout the mouse brain, although its ...
Wang Kun +9 more
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The role of insulin receptor substrate 2 in hypothalamic and β cell function [PDF]
Insulin receptor substrate 2 (Irs2) plays complex roles in energy homeostasis. We generated mice lacking Irs2 in β cells and a population of hypothalamic neurons (RIPCreIrs2KO), in all neurons (NesCreIrs2KO), and in proopiomelanocortin neurons ...
Hisadome, Kazunari +59 more
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Association of MC1R Variants and host phenotypes with melanoma risk in CDKN2A mutation carriers: a GenoMEL study [PDF]
<p><b>Background</b> Carrying the cyclin-dependent kinase inhibitor 2A (CDKN2A) germline mutations is associated with a high risk for melanoma. Penetrance of CDKN2A mutations is modified by pigmentation characteristics, nevus phenotypes,
Pastorino, L. +274 more
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