Results 21 to 30 of about 46,847 (156)
The melanocortin pathway and energy homeostasis: From discovery to obesity therapy
Molecular Metabolism, 2021 Background: Over the past 20 years, insights from human and mouse genetics have illuminated the central role of the brain leptin-melanocortin pathway in controlling mammalian food intake, with genetic disruption resulting in extreme obesity, and more ...
Giles S.H. Yeo +14 more
doaj +1 more source
Melanocortin-4 receptor regulation of pain
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 2017 An increasingly high occurrence of chronic pain in patients highlights the importance of fundamental research. The melanocortin-4 receptor (MC4R) regulation of pain has attracted much attention in recent years due to its high expression in the mammalian brain regions related to nociception and pain.
Zhi-Xiao, Li +3 more
openaire +2 more sources
Melanocortin-4 receptor–regulated energy homeostasis [PDF]
Nature Neuroscience, 2016 The melanocortin system provides a conceptual blueprint for the central control of energetic state. Defined by four principal molecular components--two antagonistically acting ligands and two cognate receptors--this phylogenetically conserved system serves as a prototype for hierarchical energy balance regulation.
Michael J, Krashes +2 more
openaire +2 more sources
The melanocortin action is biased toward protection from weight loss in mice
Nature Communications, 2023 The melanocortin action is well perceived for its ability to regulate body weight bidirectionally with its gain of function reducing body weight and loss of function promoting obesity.
Hongli Li +11 more
doaj +1 more source
Melanocortin 4 receptors switch reward to aversion [PDF]
Journal of Clinical Investigation, 2018 The ability to recognize and avoid noxious stimuli is essential for survival. The factors that determine whether a given stimulus is considered positive or negative are complex and not fully understood. In this issue of the JCI, Klawonn and colleagues demonstrate that melanocortin 4 receptor (MC4R) signaling is critical for proper responses to negative
Alexandra G, DiFeliceantonio +1 more
openaire +2 more sources
MRAP2 regulates ghrelin receptor signaling and hunger sensing
Nature Communications, 2017 Melanocortin receptor accessory protein 2 (MRAP2) is an adaptor protein that contributes to melanocortin-4 receptor and prokineticin receptor 1 signalling.
Dollada Srisai +6 more
doaj +1 more source
Frontiers in Behavioral Neuroscience, 2015 Introduction: Conflicting data exist on sensitivity changes of the melanocortin system during diet-induced obesity. We hypothesized that melanocortin sensitivity depends on diet composition, in particular on the fat content rather than the level of ...
José eVan Den Heuvel +7 more
doaj +1 more source
The effect of human wharton’s jelly-derived mesenchymal stem cells on MC4R, NPY, and LEPR gene expression levels in rats with streptozotocin-induced diabetes [PDF]
Iranian Journal of Basic Medical Sciences, 2020 Objective(s): Type 1 diabetes (T1D) is an autoimmune disease resulting from inflammatory destruction of islets β-cells. Nowadays, progress in cell therapy, especially mesenchymal stem cells (MSCs) proposes numerous potential remedies for T1D. We aimed to
Fatemeh Sabet Sarvestani +5 more
doaj +1 more source
Advances in Human Biology, 2023 Introduction: Obesity is primarily caused by the dysfunction of the energy homeostasis system. Numerous studies have reported an association between obesity and the rs17782313 variant near the melanocortin-4 receptor (MC4R) gene.
Yasaman Ansari +5 more
doaj +1 more source
Melanocortin receptor accessory proteins in adrenal disease and obesity
Frontiers in Neuroscience, 2015 Melanocortin receptor accessory proteins (MRAPs) are regulators of the melanocortin receptor family. MRAP is an essential accessory factor for the functional expression of the MC2R/ACTH receptor.
David eJackson +3 more
doaj +1 more source