Results 21 to 30 of about 60,342 (231)

Targeting melanocortin 4 receptor to treat sleep-disordered breathing in mice [PDF]

The Journal of Clinical Investigation
Weight loss medications are emerging candidates for pharmacotherapy of sleep-disordered breathing (SDB). A melanocortin 4 receptor (MC4R) agonist, setmelanotide (Set), is used to treat obesity caused by abnormal melanocortin and leptin signaling.
Mateus R. Amorim, Noah R. Williams, O. Aung, Melanie Alexis Ruiz, Frederick Anokye-Danso, Junia L. de Deus, Jiali Xiong, Olga Dergacheva, Shannon Bevans-Fonti, Sean M. Lee, Jeffrey S. Berger, Mark N. Wu, Rexford S. Ahima, David Mendelowitz, Vsevolod Y. Polotsky   +14 more
doaj   +2 more sources

Binding, Thermodynamics, and Selectivity of a Non-peptide Antagonist to the Melanocortin-4 Receptor [PDF]

Frontiers in Pharmacology, 2018
The melanocortin-4 receptor (MC4R) is a potential drug target for treatment of obesity, anxiety, depression, and sexual dysfunction. Crystal structures for MC4R are not yet available, which has hindered successful structure-based drug design.
Noureldin Saleh, Noureldin Saleh, Gunnar Kleinau, Gunnar Kleinau, Nicolas Heyder, Nicolas Heyder, Timothy Clark, Peter W. Hildebrand, Peter W. Hildebrand, Peter W. Hildebrand, Patrick Scheerer, Patrick Scheerer   +11 more
doaj   +4 more sources

Melanocortin 4 receptor signaling in Sim1 neurons permits sexual receptivity in female mice [PDF]

Frontiers in Endocrinology, 2023
IntroductionFemale sexual dysfunction affects approximately 40% of women in the United States, yet few therapeutic options exist for these patients. The melanocortin system is a new treatment target for hypoactive sexual desire disorder (HSDD), but the ...
Erin A. Semple, Mitchell T. Harberson, Baijie Xu, Rebecca Rashleigh, Tori L. Cartwright, Jessica J. Braun, Amy C. Custer, Chen Liu, Jennifer W. Hill, Jennifer W. Hill   +9 more
doaj   +2 more sources

Proopiomelanocortin Deficiency Treated with a Melanocortin-4 Receptor Agonist

New England Journal of Medicine, 2016
Patients with rare defects in the gene encoding proopiomelanocortin (POMC) have extreme early-onset obesity, hyperphagia, hypopigmentation, and hypocortisolism, resulting from the lack of the proopiomelanocortin-derived peptides melanocyte-stimulating hormone and corticotropin. In such patients, adrenal insufficiency must be treated with hydrocortisone
Peter, Kühnen, Karine, Clément, Susanna, Wiegand, Oliver, Blankenstein, Keith, Gottesdiener, Lea L, Martini, Knut, Mai, Ulrike, Blume-Peytavi, Annette, Grüters, Heiko, Krude   +9 more
openaire   +4 more sources

Regulation of lean mass, bone mass, and exercise tolerance by the central melanocortin system. [PDF]

PLoS ONE, 2012
Signaling via the type 4-melanocortin receptor (MC4R) is an important determinant of body weight in mice and humans, where loss of function mutations lead to significant obesity.
Theodore P Braun, Benjamin Orwoll, Xinxia Zhu, Peter R Levasseur, Marek Szumowski, My Linh T Nguyen, Mary L Bouxsein, Robert F Klein, Daniel L Marks   +8 more
doaj   +5 more sources

CREB coactivator CRTC1 in melanocortin‐4 receptor‐expressing cells regulate dietary fat intake [PDF]

FASEB BioAdvances
Cyclic adenosine monophosphate‐response element‐binding protein‐1‐regulated transcription coactivator‐1 (CRTC1), a cytoplasmic coactivator that translocates to the nucleus in response to cAMP, is associated with obesity. We previously reported that CRTC1
Shigenobu Matsumura, Miyu Fujisawa, Mizuki Fujiwara, Houko Okayama, Miona Marutani, Eri Nousou, Tsutomu Sasaki, Naoki Harada   +7 more
doaj   +2 more sources

Melanocortin-4 receptor and leptin as genes for the selection of superior Madrasin cattle [PDF]

Veterinary World, 2021
Background and Aim: The genetic improvement of cattle through livestock section is based on quantitative, qualitative, and molecular characteristics. This study examined polymorphisms of the melanocortin-4 receptor (MC4R) and leptin genes as a reference ...
Budi Utomo, Rimayanti Rimayanti, Indah Norma Triana, Amaq Fadholly   +3 more
doaj   +1 more source

Genetic obesity: an update with emerging therapeutic approaches [PDF]

Annals of Pediatric Endocrinology & Metabolism, 2022
Based on the genetic contribution, childhood obesity can be classified into 3 groups: common polygenic obesity, syndromic obesity, and monogenic obesity.
Young Bae Sohn
doaj   +1 more source

Regulation of Melanocortin-3 and -4 Receptors by Isoforms of Melanocortin-2 Receptor Accessory Protein 1 and 2

Biomolecules, 2022
The neural melanocortin receptors (MCRs), melanocortin-3 and -4 receptors (MC3R and MC4R), play essential non-redundant roles in the regulation of energy homeostasis. Interaction of neural MCRs and melanocortin-2 receptor accessory proteins (MRAPs, MRAP1
Ren-Lei Ji, Ya-Xiong Tao
doaj   +1 more source

Modulation of Canine Melanocortin-3 and -4 Receptors by Melanocortin-2 Receptor Accessory Protein 1 and 2

Biomolecules, 2022
The neural melanocortin receptors (MCRs), melanocortin-3 and -4 receptors (MC3R and MC4R), have crucial roles in regulating energy homeostasis. The melanocortin-2 receptor accessory proteins (MRAPs, MRAP1 and MRAP2) have been shown to regulate neural ...
Ren-Lei Ji, Shan-Shan Jiang, Ya-Xiong Tao   +2 more
doaj   +1 more source