Results 51 to 60 of about 60,342 (231)
Molecular Metabolism, 2020 Objective: Histaminergic neurons of the tuberomammillary nucleus (TMN) are wake-promoting and contribute to the regulation of energy homeostasis. Evidence indicates that melanocortin 4 receptors (MC4R) are expressed within the TMN.
Natalie J. Michael +7 more
doaj +1 more source
A neural basis for melanocortin-4 receptor–regulated appetite [PDF]
Nature Neuroscience, 2015 Pro-opiomelanocortin (POMC)- and agouti-related peptide (AgRP)-expressing neurons of the arcuate nucleus of the hypothalamus (ARC) are oppositely regulated by caloric depletion and coordinately stimulate and inhibit homeostatic satiety, respectively. This bimodality is principally underscored by the antagonistic actions of these ligands at downstream ...
Garfield, Alastair S. +13 more
openaire +3 more sources
Journal of Applied Animal Research, 2021 This paper presents the results on the study of melanocortin-4 receptor (MC4R) gene polymorphisms in sheep of the Karachai breed. AA, AG, and GG genotypes were determined to have allele frequencies of 47%, 37%, and 16%, respectively, indicating that ...
Ivan Fiodorovich Gorlov +12 more
doaj +1 more source
Peripheral actions and direct central–local communications of melanocortin 4 receptor signaling
Journal of Sport and Health Science, 2023 Melanocortin 4 receptor (MC4R), the most important monogenetic cause of human metabolic disorders, has been of great interest to many researchers in the field of energy homeostasis and public health.
Lei Li +4 more
doaj +1 more source
Subcellular localization of MC4R with ADCY3 at neuronal primary cilia underlies a common pathway for genetic predisposition to obesity. [PDF]
, 2018 Most monogenic cases of obesity in humans have been linked to mutations in genes encoding members of the leptin-melanocortin pathway. Specifically, mutations in MC4R, the melanocortin-4 receptor gene, account for 3-5% of all severe obesity cases in ...
A Hinney +38 more
core +1 more source
Frontiers in Immunology, 2019 To date, available treatment strategies for multiple sclerosis (MS) are ineffective in preventing or reversing progressive neurologic deterioration, creating a high, and unmet medical need. One potential way to fight MS may be by limiting the detrimental
Alwin Kamermans +8 more
doaj +1 more source
Evaluation of a melanocortin-4 receptor (MC4R) agonist (Setmelanotide) in MC4R deficiency
Molecular Metabolism, 2017 Objective: Pro-opiomelanocortin (POMC)-derived peptides act on neurons expressing the Melanocortin 4 receptor (MC4R) to reduce body weight. Setmelanotide is a highly potent MC4R agonist that leads to weight loss in diet-induced obese animals and in obese
Tinh-Hai Collet +27 more
doaj +1 more source
Melanocortin 1 receptor targeted imaging of melanoma with gold nanocages and positron emission tomography [PDF]
, 2018 Purpose: Melanoma is a lethal skin cancer with unmet clinical needs for targeted imaging and therapy. Nanoscale materials conjugated with targeting components have shown great potential to improve tumor delivery efficiency while minimizing undesirable ...
Black, Kvar +8 more
core +2 more sources
Melanotan-II reverses autistic features in a maternal immune activation mouse model of autism [PDF]
, 2019 Autism spectrum disorder (ASD) is a complex neurodevelopmental disorder characterized by impaired social interactions, difficulty with communication, and repetitive behavior patterns. In humans affected by ASD, there is a male pre-disposition towards the
Gould, Georgianna G +7 more
core +2 more sources
Frontiers in Endocrinology, 2020 Melanocortin-4 receptor (MC4R) plays important roles in regulation of multiple physiological processes, and interaction of MC4R and melanocortin receptor accessory protein 2 (MRAP2) is suggested to play pivotal role in energy balance of vertebrates ...
Min Tao +7 more
doaj +1 more source