The melanocortin receptors as targets for general obesity: contextualizing clinical failures and analyzing future perspectives [PDF]
Frontiers in EndocrinologyThe melanocortin system is a genetically conserved and clinically validated target for the treatment of obesity. Hundreds of studies establish the role of the melanocortin receptors, particularly the melanocortin-4 receptor, in food intake, weight ...
Claudia R. Prindle +7 more
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Development of a genetically encoded melanocortin sensor for high sensitivity in vivo imaging [PDF]
Molecular MetabolismObjective: The central melanocortin system, composed of peptides derived from pro-opiomelanocortin (POMC) such as the melanocyte-stimulating hormones (α-, β-, γ-MSH) and melanocortin 4 receptors (MC4R), along with the agouti-related protein (AgRP), plays
Yoon Namkung +6 more
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Melanocortin System in Kidney Homeostasis and Disease: Novel Therapeutic Opportunities
Frontiers in Physiology, 2021 Melanocortin peptides, melanocortin receptors, melanocortin receptor accessory proteins, and endogenous antagonists of melanocortin receptors are the key components constituting the melanocortin hormone system, one of the most complex and important ...
Mingyang Chang +4 more
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Evidence for an interaction between cannabinoidergic and dopaminergic systems with melanocortin MC3/ MC4 receptors in regulating food intake of neonatal chick [PDF]
The Iranian Journal of Veterinary Science and Technology, 2021 The current study aimed to see how the central dopaminergic and cannabinoidergic mechanisms affect melanocortin-induced food intake in the neonatal layer chickens. In this regard, 9 experiments were designed. In experiment 1, chicks injected with control
Mohammad Bameri +4 more
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Melanocortin therapies to resolve fibroblast-mediated diseases
Frontiers in Immunology, 2023 Stromal cells have emerged as central drivers in multiple and diverse diseases, and consequently, as potential new cellular targets for the development of novel therapeutic strategies.
Natalya Khodeneva +3 more
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Melasma Clinical Features, Diagnosis, Epidemiology and Etiology: An Update Review
Siriraj Medical Journal, 2021 Melasma is one of the commonest dermatological challenges that facing dermatologists in the whole world. Most of the previously published articles regarding melasma usually focused on its management and the newly discovered drugs; however, the ...
Mohammad Ahmad Abdalla
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Frontiers in Immunology, 2023 IntroductionPL8177 is a potent and selective agonist of the melanocortin 1 receptor (MC1R). PL8177 has shown efficacy in reversing intestinal inflammation in a cannulated rat ulcerative colitis model.
John Dodd +8 more
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Differential Signaling Profiles of MC4R Mutations with Three Different Ligands [PDF]
, 2020 The melanocortin 4 receptor (MC4R) is a key player in hypothalamic weight regulation and energy expenditure as part of the leptin-melanocortin pathway. Mutations in this G protein coupled receptor (GPCR) are the most common cause for monogenetic obesity,
Annibale, Paolo +8 more
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Impact of the Central Histaminergic and Melanocortin Systems on Leptin-Induced Hypophagia in Neonatal Layer Chicken [PDF]
Archives of Razi Institute, 2021 The present study aimed to assess the probable impact of the central histaminergic and melanocortin systems on leptin-induced hypophagia in neonatal layer chickens.
M Shalikar +3 more
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Melanocortin 4 receptor signaling in Sim1 neurons permits sexual receptivity in female mice
Frontiers in Endocrinology, 2023 IntroductionFemale sexual dysfunction affects approximately 40% of women in the United States, yet few therapeutic options exist for these patients. The melanocortin system is a new treatment target for hypoactive sexual desire disorder (HSDD), but the ...
Erin A. Semple +9 more
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