Results 41 to 50 of about 57,827 (240)

Neurobiology of inflammation-associated anorexia

Frontiers in Neuroscience, 2010
Compelling data demonstrate that inflammation-associated anorexia directly results from the action of pro-inflammatory factors, primarily cytokines and prostaglandins E2, on the nervous system.
Laurent Gautron, Sophie Laye
doaj   +1 more source

L-Cell Expression of Melanocortin-4-Receptor Is Marginal in Most of the Small Intestine in Mice and Humans and Direct Stimulation of Small Intestinal Melanocortin-4-Receptors in Mice and Rats Does Not Affect GLP-1 Secretion

Frontiers in Endocrinology, 2021
The molecular sensors underlying nutrient-stimulated GLP-1 secretion are currently being investigated. Peripheral administration of melanocortin-4 receptor (MC4R) agonists have been reported to increase GLP-1 plasma concentrations in mice and humans but ...
Rune E. Kuhre, Rune E. Kuhre, Rune E. Kuhre, Ida M. Modvig, Ida M. Modvig, Sara L. Jepsen, Sara L. Jepsen, Hüsün S. Kizilkaya, Cecilie Bæch-Laursen, Cecilie Bæch-Laursen, Christopher A. Smith, Frank Reimann, Fiona M. Gribble, Mette M. Rosenkilde, Jens J. Holst, Jens J. Holst   +15 more
doaj   +1 more source

Histaminergic regulation of food intake

Frontiers in Endocrinology, 2023
Histamine is a biogenic amine that acts as a neuromodulator within the brain. In the hypothalamus, histaminergic signaling contributes to the regulation of numerous physiological and homeostatic processes, including the regulation of energy balance ...
Axelle Khouma, Axelle Khouma, Moein Minbashi Moeini, Moein Minbashi Moeini, Julie Plamondon, Denis Richard, Denis Richard, Alexandre Caron, Alexandre Caron, Alexandre Caron, Natalie Jane Michael, Natalie Jane Michael   +11 more
doaj   +1 more source

melanocortin

, 2013
Melanocortin sequence ...
Sistrom, Mark J., Donnellan, Steve C., Hutchinson, Mark N., Terry Bertozzi (3267612), Mark J. Sistrom (3247140), Steve C. Donnellan (3267615), Bertozzi, Terry, Mark N. Hutchinson (3267609)   +7 more
core   +1 more source

Subdiaphragmatic Vagotomy With Pyloroplasty Ameliorates the Obesity Caused by Genetic Deletion of the Melanocortin 4 Receptor in the Mouse

Frontiers in Neuroscience, 2018
Background/Objectives: We tested the hypothesis that abolishing vagal nerve activity will reverse the obesity phenotype of melanocortin 4 receptor knockout mice (Mc4r−/−).Subjects/Methods: In two separate studies, we examined the efficacy of bilateral ...
Ghazaul Dezfuli, Richard A. Gillis, Jaclyn E. Tatge, Kimbell R. Duncan, Kenneth L. Dretchen, Patrick G. Jackson, Joseph G. Verbalis, Niaz Sahibzada   +7 more
doaj   +1 more source

Case Report: Improvement in cognitive functioning following setmelanotide initiation in a patient with Bardet-Biedl syndrome

Frontiers in Endocrinology
Bardet-Biedl syndrome (BBS) is a rare genetic condition that results from mutations in a variety of genes crucial for ciliary transport. Consequently, patients with BBS present with a wide array of clinical signs and symptoms that include multiple organ ...
Menjin Kuk, Jesse Richards, Rachel A. Ross   +2 more
doaj   +1 more source

Activation of the ARCPOMC→MeA Projection Reduces Food Intake

Frontiers in Neural Circuits, 2020
Proopiomelanocortin (POMC) neurons in the arcuate nucleus of the hypothalamus (ARC) plays an essential role in the control of food intake and energy expenditure.
Eunjin Kwon, Eunjin Kwon, Young-Hwan Jo, Young-Hwan Jo, Young-Hwan Jo   +4 more
doaj   +1 more source

The melanocortin action is biased toward protection from weight loss in mice

Nature Communications, 2023
The melanocortin action is well perceived for its ability to regulate body weight bidirectionally with its gain of function reducing body weight and loss of function promoting obesity.
Hongli Li, Yuanzhong Xu, Yanyan Jiang, Zhiying Jiang, Joshua Otiz-Guzman, Jessie C. Morrill, Jing Cai, Zhengmei Mao, Yong Xu, Benjamin R. Arenkiel, Cheng Huang, Qingchun Tong   +11 more
doaj   +1 more source

The Melanocortin System in Inflammatory Bowel Diseases: Insights into Its Mechanisms and Therapeutic Potentials

Cells, 2023
The melanocortin system is a complex set of molecular mediators and receptors involved in many physiological and homeostatic processes. These include the regulation of melanogenesis, steroidogenesis, neuromodulation and the modulation of inflammatory ...
Antonietta Gerarda Gravina, Raffaele Pellegrino, Tommaso Durante, Giovanna Palladino, Giuseppe Imperio, Giovanbattista D’Amico, Maria Consiglia Trotta, Marcello Dallio, Mario Romeo, Michele D’Amico, Alessandro Federico   +10 more
doaj   +1 more source

Phenotypic characteristics of familial glucocorticoid deficiency (FGD) type 1 and 2 [PDF]

, 2010
Context: Familial glucocorticoid deficiency (FGD) is a rare autosomal recessive disorder as a result of mutation in genes encoding either the ACTH receptor [melanocortin 2 receptor (MC2R)] or its accessory protein [melanocortin 2 receptor accessory ...
Metherell, LA, Chung, TTLL, Clark, AJ, Chung, TT, Chan, LF, Clark, AJL   +5 more
core   +1 more source