Results 51 to 60 of about 57,827 (240)

TrpC5 Mediates Acute Leptin and Serotonin Effects via Pomc Neurons

Cell Reports, 2017
The molecular mechanisms underlying acute leptin and serotonin 2C receptor-induced hypophagia remain unclear. Here, we show that neuronal and pro-opiomelanocortin (Pomc)-specific loss of transient receptor potential cation 5 (TrpC5) subunits is ...
Yong Gao, Ting Yao, Zhuo Deng, Jong-Woo Sohn, Jia Sun, Yiru Huang, Xingxing Kong, Kai-jiang Yu, Rui-tao Wang, Hong Chen, Hongbo Guo, Jianqun Yan, Kathryn A. Cunningham, Yongsheng Chang, Tiemin Liu, Kevin W. Williams   +15 more
doaj   +1 more source

Exercise-induced hypothalamic neuroplasticity: Implications for energy and glucose metabolism

Molecular Metabolism, 2023
Background: Neuroplasticity refers to the brain's ability to undergo functional and structural changes in response to diverse challenges. Converging evidence supports the notion that exercise serves as a metabolic challenge, triggering the release of ...
Eunsang Hwang, Bryan Portillo, Kyle Grose, Teppei Fujikawa, Kevin W. Williams   +4 more
doaj   +1 more source

MRAP2 modifies the signaling and oligomerization state of the melanocortin-4 receptor

Nature Communications
The melanocortin-4 receptor is a G protein-coupled receptor and a key regulator of appetite and metabolism. It can interact with the melanocortin-receptor accessory protein 2, a single transmembrane helix protein known to interact with several different ...
Iqra Sohail, Suli-Anne Laurin, Gunnar Kleinau, Vidicha Chunilal, Andrew Morton, Alfonso Brenlla, Zeynep Cansu Uretmen Kagiali, Marie-José Blouin, Javier A. Tello, Annette G. Beck-Sickinger, Martin J. Lohse, Patrick Scheerer, Michel Bouvier, Peter McCormick, Paolo Annibale, Heike Biebermann   +15 more
doaj   +1 more source

Restored TDCA and valine levels imitate the effects of bariatric surgery

eLife, 2021
Background: Obesity is widespread and linked to various co-morbidities. Bariatric surgery has been identified as the only effective treatment, promoting sustained weight loss and the remission of co-morbidities. Methods: Metabolic profiling was performed
Markus Quante, Jasper Iske, Timm Heinbokel, Bhavna N Desai, Hector Rodriguez Cetina Biefer, Yeqi Nian, Felix Krenzien, Tomohisa Matsunaga, Hirofumi Uehara, Ryoichi Maenosono, Haruhito Azuma, Johann Pratschke, Christine S Falk, Tammy Lo, Eric Sheu, Ali Tavakkoli, Reza Abdi, David Perkins, Maria-Luisa Alegre, Alexander S Banks, Hao Zhou, Abdallah Elkhal, Stefan G Tullius   +22 more
doaj   +1 more source

Untersuchungen zur ligandenvermittelten Regulation der Melanocortin-Rezeptor-Aktivität

, 2011
Die vorliegende Arbeit stellt die Ergebniss von Untersuchungen zur ligandenvermittelten Regulation der Melanocortin-Rezeptor-Aktivität dar. Melanocortin-Rezeptoren (MCR) spielen eine entscheidende Rolle in der Regulation des Energiehaushalts.
Wolff, Katharina (112068103)
core   +2 more sources

Genetic Diversity, Adaptation, Wild Introgression, and Coat Color Mutation of Golden Yak

Animal Research and One Health, EarlyView.
Genetic diversity, adaptation, wild introgression, and coat color mutation of golden yak from two populations on the Qinghai‐Xizang Plateau. ABSTRACT The golden yak lives on the Qinghai‐Xizang Plateau with a golden coat and adapts to high altitudes and strong ultraviolet environment. The golden coat is a prominent phenotype in many domesticated species,
Huixuan Yan, Jialei Chen, Chuzhao Lei, Fengwei Zhang, Shunzhong He, Weiru Song, Hongyan Ma, Shuling Li, Guomei Li, Laba Yongcuo, Jianlin Han, Johannes A. Lenstra, Qiang Zhang, Rende Song, Basang Wangdui, Ningbo Chen   +15 more
wiley   +1 more source

Agouti-Signalling Protein Overexpression Reduces Aggressiveness in Zebrafish

Biology, 2023
Feeding motivation plays a crucial role in food intake and growth. It closely depends on hunger and satiation, which are controlled by the melanocortin system.
Ana Rocha, Alejandra Godino-Gimeno, Josep Rotllant, José Miguel Cerdá-Reverter   +3 more
doaj   +1 more source

Hypertension in obesity: A focus on individualized pharmacotherapy and the role of body composition, on behalf of the European Society of Hypertension Working Group on Diabetes and Metabolic Risk Factors and Working Group on Lifestyle, Cardiovascular Pharmacotherapy and Adherence

British Journal of Clinical Pharmacology, EarlyView.
Hypertension in obesity represents a major global health challenge, closely linked to the global epidemics of obesity, type 2 diabetes and metabolic dysfunction. Excess adiposity contributes to elevated blood pressure through multiple, interrelated mechanisms, including activation of the renin–angiotensin–aldosterone system, sympathetic nervous system ...
Christina Antza, Andrej Belancic, Jens Jordan, Alberto Esteban, Anna Oliveras, Ryan McNally, Panagiota Anyfanti, Jorie Versmissen, María S. Fernández‐Alfonso, Vasilios Kotsis, Thomas Weber, Alexandre Persu, Reinhold Kreutz   +12 more
wiley   +1 more source

Discovery of Nanomolar Melanocortin-3 Receptor (MC3R)-Selective Small Molecule Pyrrolidine Bis-Cyclic Guanidine Agonist Compounds Via a High-Throughput unbiased Screening Campaign

, 2021
The central melanocortin-3 and melanocortin-4 receptors (MC3R, MC4R) are key regulators of body weight and energy homeostasis. Herein, the discovery and characterization of first-in-class small molecule melanocortin agonists with selectivity for the ...
Debevec, Ginamarie, Lavoi, Travis M., Pinilla, Clemencia, Haskell-Luevano, Carrie, Freeman, Katie, Santos, Radleigh G., Houghten, Richard A., Ericson, Mark D., Appel, Jon R., Geer, Phaedra, Giulianotti, Marc A., Doering, Skye R., Carrie Haskell-Luevano, Marc A. Giulianotti, Clemencia Pinilla, Travis M. Lavoi, Mark D. Ericson, Phaedra Geer, Ginamarie Debevec, Jon R. Appel, Katie Freeman, Radleigh G. Santos, Richard A. Houghten, Skye R. Doering   +23 more
core   +1 more source

Inhibitory effect of the melanocortin receptor agonist melanotan-II (MTII) on feeding depends on dietary fat content and not obesity in rats on free-choice diets

Frontiers in Behavioral Neuroscience, 2015
Introduction: Conflicting data exist on sensitivity changes of the melanocortin system during diet-induced obesity. We hypothesized that melanocortin sensitivity depends on diet composition, in particular on the fat content rather than the level of ...
José eVan Den Heuvel, Leslie eEggels, Andrea evan Rozen, Eric eFliers, Andries eKalsbeek, Andries eKalsbeek, Roger eAdan, Susanne E la Fleur   +7 more
doaj   +1 more source