Results 1 to 10 of about 189,310 (233)

Marchf6 E3 ubiquitin ligase critically regulates endoplasmic reticulum stress, ferroptosis, and metabolic homeostasis in POMC neurons

Cell Reports, 2023
Summary: The metabolic prohormone pro-opiomelanocortin (POMC) is generally translocated into the endoplasmic reticulum (ER) for entry into the secretory pathway.
Sang-Hyeon Mun, Chang-Seok Lee, Hyun Jin Kim, Jiye Kim, Haena Lee, Jihye Yang, Sin-Hyeog Im, Joung-Hun Kim, Je Kyung Seong, Cheol-Sang Hwang   +9 more
doaj   +2 more sources

POMC neuron METTL14/m6A/YTHDC1/YTHDF2 pathways safeguard energy balance, body weight, and metabolism [PDF]

Nature Communications
METTL14 mediates N6-methyladenosine (m6A) RNA modification, while YTHDC1 and YTHDF2 specifically bind m6A-methylated RNA to regulate RNA fate. POMC neurons constitute the core of the central melanocortin circuit, and POMC deficiency causes obesity in ...
Yuan Li, Min-Hyun Kim, Decheng Ren, Liangyou Rui   +3 more
doaj   +2 more sources

Mild Impairment of Mitochondrial OXPHOS Promotes Fatty Acid Utilization in POMC Neurons and Improves Glucose Homeostasis in Obesity

Cell Reports, 2018
Summary: Mitochondrial oxidative phosphorylation (OXPHOS) and substrate utilization critically regulate the function of hypothalamic proopiomelanocortin (POMC)-expressing neurons.
Luis Varela, Lars Paeger, Peter Kloppenburg   +2 more
exaly   +3 more sources

Casein kinase 1α is required to maintain murine hypothalamic pro-opiomelanocortin expression

iScience, 2023
Summary: Hypothalamic pro-opiomelanocortin (POMC) neuron development is considered to play an essential role in the development of obesity. However, the underlying mechanisms remain unclear.
Chenyang Lu, Jinglin Zhang, Bingjie Wang, Qiao Gao, Kezhe Ma, Shaona Pei, Juxue Li, Sheng Cui   +7 more
doaj   +1 more source

Adult-born proopiomelanocortin neurons derived from Rax-expressing precursors mitigate the metabolic effects of congenital hypothalamic proopiomelanocortin deficiency

Molecular Metabolism, 2021
Objective: Proopiomelanocortin (POMC) neurons of the hypothalamic arcuate nucleus are essential regulators of energy balance. Selective loss of POMC production in these cells results in extreme obesity and metabolic comorbidities.
Surbhi, Gábor Wittmann, Malcolm J. Low, Ronald M. Lechan   +3 more
doaj   +1 more source

Hypothalamic agrp and pomc mRNA Responses to Gastrointestinal Fullness and Fasting in Atlantic Salmon (Salmo salar, L.)

Frontiers in Physiology, 2020
The orexigenic agouti-related protein (AgRP) and the anorexigenic pro-opiomelanocortin (POMC) are crucial players in the control of feed intake in vertebrates, yet their role in teleosts has not been fully established.
Tharmini Kalananthan, Koji Murashita, Koji Murashita, Ivar Rønnestad, Mitsumasa Ishigaki, Kota Takahashi, Marta S. Silva, Marta S. Silva, Yuki Wakabayashi, Floriana Lai, Munetaka Shimizu, Tom O. Nilsen, Tom O. Nilsen, Enrique Pino Martinez, Enrique Pino Martinez, Ana S. Gomes   +15 more
doaj   +1 more source

SK3 in POMC neurons plays a sexually dimorphic role in energy and glucose homeostasis

Cell & Bioscience, 2022
Background Pro-opiomelanocortin (POMC) neurons play a sexually dimorphic role in body weight and glucose balance. However, the mechanisms for the sex differences in POMC neuron functions are not fully understood.
Meng Yu, Jonathan C. Bean, Hailan Liu, Yang He, Yongjie Yang, Xing Cai, Kaifan Yu, Zhou Pei, Hesong Liu, Longlong Tu, Kristine M. Conde, Mengjie Wang, Yongxiang Li, Na Yin, Nan Zhang, Junying Han, Nikolas A. Scarcelli, Pingwen Xu, Yanlin He, Yong Xu, Chunmei Wang   +20 more
doaj   +1 more source

Hypothalamic Pomc expression restricted to GABAergic neurons suppresses Npy overexpression and restores food intake in obese mice

Molecular Metabolism, 2020
Objective: Hypothalamic arcuate proopiomelanocortin (Arc-POMC) neurons are involved in different physiological processes such as the regulation of energy balance, glucose homeostasis, and stress-induced analgesia.
Milagros Trotta, Estefanía Pilar Bello, Ramiro Alsina, María Belén Tavella, José Luis Ferrán, Marcelo Rubinstein, Viviana Florencia Bumaschny   +6 more
doaj   +1 more source

Developmental single-cell transcriptomics of hypothalamic POMC neurons reveal the genetic trajectories of multiple neuropeptidergic phenotypes

eLife, 2022
Proopiomelanocortin (POMC) neurons of the hypothalamic arcuate nucleus are essential to regulate food intake and energy balance. However, the ontogenetic transcriptional programs that specify the identity and functioning of these neurons are poorly ...
Hui Yu, Marcelo Rubinstein, Malcolm J Low   +2 more
doaj   +1 more source

Relative number and distribution of murine hypothalamic proopiomelanocortin neurons innervating distinct target sites. [PDF]

PLoS ONE, 2011
Proopiomelanocortin (POMC) neurons send projections widely throughout the brain consistent with their role in regulating numerous homeostatic processes and mediating analgesia and reward.
Connie M King, Shane T Hentges
doaj   +1 more source