Results 41 to 50 of about 179,797 (233)

60 YEARS OF POMC: Transcriptional and epigenetic regulation of POMC gene expression [PDF]

Journal of Molecular Endocrinology, 2016
Expression of the pro-opiomelanocortin (POMC) gene integrates numerous inputs that reflect the developmental history of POMC-expressing cells of the pituitary and hypothalamus, as well as their critical role in the endocrine system. These inputs are integrated at specific regulatory sequences within the promoter and pituitary or hypothalamic enhancers ...
openaire   +2 more sources

Loss of POMC-mediated antinociception contributes to painful diabetic neuropathy.

, 2021
Painful neuropathy is a frequent complication in diabetes. Proopiomelanocortin (POMC) is an endogenous opioid precursor peptide, which plays a protective role against pain. Here, we report dysfunctional POMC-mediated antinociception in sensory neurons in
Klose, C.S.N., Fleming, T., Fleming, Thomas, Deshpande, D., Gaveriaux-Ruff, Claire, Klose, Christophe S. N., Kuner, Roani, Kuner, R., Agarwal, Nitin, Tappe-Theodor, Anke, Deshpande, Divija, Agarwal, N., Nawroth, P.P., Tappe-Theodor, A., Nawroth, Peter   +14 more
core   +1 more source

G Protein-Coupled Receptor 17 (Gpr17) Enhances Leptin and Insulin Sensitivity in Lean and Obese Mouse Models. [PDF]

Obesity (Silver Spring)
This study identifies G protein‐coupled receptor 17 (Gpr17) as a novel regulator of leptin and insulin sensitivity. Using complementary knockout models, we demonstrate that Gpr17 deletion enhances energy expenditure, restores leptin responsiveness, and improves insulin sensitivity, revealing Gpr17 as a potential therapeutic GPCR target for obesity and ...
Sun X, Mahler C, Stull ND, Nasiri A, Zhou B, Samuel V, Shulman G, Flak JN, Ren H.   +8 more
europepmc   +2 more sources

Calcium Channel CaV2.3 Subunits Regulate Hepatic Glucose Production by Modulating Leptin-Induced Excitation of Arcuate Pro-opiomelanocortin Neurons

Cell Reports, 2018
Summary: Leptin acts on hypothalamic pro-opiomelanocortin (POMC) neurons to regulate glucose homeostasis, but the precise mechanisms remain unclear.
Mark A. Smith, Loukia Katsouri, Samuel Virtue, Agharul I. Choudhury, Antonio Vidal-Puig, Michael L.J. Ashford, Dominic J. Withers   +6 more
doaj   +1 more source

POMC

, 2013
Alignment of existing (GenBank) and newly generated ...
Jennifer B. Pramuk (3299589), de Queiroz, Kevin, Bezy, Robert L., Jack W. Sites Jr. (710756), Sites Jr., Jack W., Elizabeth A. Sinclair (3299583), Noonan, Brice P., Sinclair, Elizabeth A., Kevin de Queiroz (3273165), Brice P. Noonan (710754), Robert L. Bezy (3299586), Pramuk, Jennifer B.   +11 more
core   +1 more source

Identifying Systemic Lupus Erythematosus From Serum Proteomic Profiles Using Machine Learning and Genetic Risk Stratification

Arthritis &Rheumatology, EarlyView.
Objective Proteome‐wide risk models for lupus remain underexplored. We developed classification models to identify lupus from serum proteomic profiles. Methods Patients with lupus and individuals with other autoimmune diseases in the UK Biobank were included.
Mehmet Hocaoǧlu, Jishnu Das, Amr H. Sawalha   +2 more
wiley   +1 more source

Role of NeuroD1 on the negative regulation of Pomc expression by glucocorticoid.

PLoS ONE, 2017
The mechanism of the negative regulation of proopiomelanocortin gene (Pomc) by glucocorticoids (Gcs) is still unclear in many points. Here, we demonstrated the involvement of neurogenic differentiation factor 1 (NeuroD1) in the Gc-mediated negative ...
Rehana Parvin, Akiko Saito-Hakoda, Hiroki Shimada, Kyoko Shimizu, Erika Noro, Yasumasa Iwasaki, Ken Fujiwara, Atsushi Yokoyama, Akira Sugawara   +8 more
doaj   +1 more source

Trilogy Development of Proopiomelanocortin Neurons From Embryonic to Adult Stages in the Mice Retina

Frontiers in Cell and Developmental Biology, 2021
Proopiomelanocortin-positive amacrine cells (POMC ACs) were first discovered in adult mouse retinas in 2010; however, the development of POMC-ACs has not been studied.
Xuhong Zhang, Xiaoyu Wang, Xiaoyu Wang, Senjie Wang, Wei Peng, Rahim Ullah, Rahim Ullah, Junfen Fu, Yudong Zhou, Yudong Zhou, Ye Shen   +10 more
doaj   +1 more source

Novel insights into the metabolic action of Kiss1 neurons

Endocrine Connections, 2020
Kiss1 neurons are essential regulators of the hypothalamic–pituitary–gonadal (HPG) axis by regulating gonadotropin-releasing hormone (GnRH) release. Compelling evidence suggests that Kiss1 neurons of the arcuate nucleus (Kiss1ARC), recently identified as
Rajae Talbi, Victor M Navarro
doaj   +1 more source

Syncing Health Timing: Exploring the Interplay of Circadian Rhythms, Obesity, and Cardiovascular Diseases

Food Safety and Health, EarlyView.
Circadian rhythm disruption impairs metabolic regulation, appetite control, and vascular function, promoting obesity and cardiovascular diseases. Evidence highlights a bidirectional relationship where metabolic disorders further disturb circadian timing.
Ghizal Fatima, István Dalmadi, Anna Jánosi, Krisztina Takács, Eszter Halmy   +4 more
wiley   +1 more source