Arcuate Nucleus of the Hypothalamus: Anatomy, Physiology, and Diseases. [PDF]
Exp Neurobiol, 2023 The hypothalamus is part of the diencephalon and has several nuclei, one of which is the arcuate nucleus. The arcuate nucleus of hypothalamus (ARH) consists of neuroendocrine neurons and centrally-projecting neurons. The ARH is the center where the homeostasis of nutrition/metabolism and reproduction are maintained.
Song J, Choi SY.
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Regulation of Feeding Behavior and Body Weight by Orexigenic Neurons in the Arcuate Nucleus [PDF]
Journal of Obesity & Metabolic SyndromeThe arcuate nucleus of the hypothalamus is arguably the most important nucleus for regulating energy homeostasis and metabolism. Since its initial description in the human brain, its function in metabolic regulation has been studied extensively.
Yu Fu
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Knockdown of Mct1 in the arcuate nucleus increases food-anticipatory activity in mice [PDF]
Frontiers in PhysiologyAnimals rely on internal time-keeping mechanisms to anticipate regular events such as feeding, allowing preemptive gene expression which enables timely physiological responses. A manifestation of anticipatory mechanisms is also a rise in body temperature
Tomaz Martini +2 more
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Knocking down the neuronal lactate transporter MCT2 in the arcuate nucleus of female rats increases food intake and body weight [PDF]
Scientific ReportsIn the arcuate nucleus of the hypothalamus, tanycyte-neuron interactions regulate glucose homeostasis and feeding behavior. Previously, we reported that monocarboxylate transporters (MCT) 1 and 4 are localized in tanycytes, whereas MCT2 is present in ...
Alanis Coca +10 more
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Hypertrophy of the Anterior External Arcuate Fasciculus: A Rare Variant With Implications for the Development of the Arcuate Nucleus [PDF]
Frontiers in Neuroanatomy, 2020 A rare anatomic variant of a markedly enlarged anterior external arcuate fasciculus (AEAF) on the ventral medullary surface is reported and compared to two controls. The hypertrophic AEAF was nine times larger in diameter than normal, whereas the arcuate
Renee Stonebridge +7 more
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The restorative effect of platelet-rich plasma on estrous cycle disruption induced by arcuate nucleus lesion in female Wistar rats: An experimental study [PDF]
International Journal of Reproductive BioMedicineBackground: Successful reproduction relies on a functioning hypothalamic-pituitary-gonad axis. Damage to this axis disrupts the estrus cycle and reproductive capability.
Elham Abbasi +3 more
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Arcuate Nucleus-Dependent Regulation of Metabolism—Pathways to Obesity and Diabetes Mellitus
Endocrine Reviews, 2022 Alexander Jais +2 more
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Relative number and distribution of murine hypothalamic proopiomelanocortin neurons innervating distinct target sites. [PDF]
PLoS ONE, 2011 Proopiomelanocortin (POMC) neurons send projections widely throughout the brain consistent with their role in regulating numerous homeostatic processes and mediating analgesia and reward.
Connie M King, Shane T Hentges
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Dax1 modulates ERα-dependent hypothalamic estrogen sensing in female mice
Nature Communications, 2023 Coupling the release of pituitary hormones to the developmental stage of the oocyte is essential for female fertility. It requires estrogen to restrain kisspeptin (KISS1)-neuron pulsatility in the arcuate hypothalamic nucleus, while also exerting a surge-
Jose M. Ramos-Pittol +14 more
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NPY and VGF immunoreactivity increased in the arcuate nucleus, but decreased in the nucleus of the Tractus Solitarius, of type-II diabetic patients. [PDF]
PLoS ONE, 2012 Ample animal studies demonstrate that neuropeptides NPY and α-MSH expressed in Arcuate Nucleus and Nucleus of the Tractus Solitarius, modulate glucose homeostasis and food intake. In contrast is the absence of data validating these observations for human
Nadia Saderi +8 more
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