Through the past decade of research, the pathogenic mechanisms underlying metabolic syndrome have been suggested to involve not only the peripheral tissues, but also central metabolic regulation imbalances.
Yinqiong Huang +3 more
doaj +1 more source
Ventromedial Arcuate Nucleus Communicates Peripheral Metabolic Information to the Suprachiasmatic Nucleus [PDF]
The arcuate nucleus (ARC) is crucial for the maintenance of energy homeostasis as an integrator of long- and short-term hunger and satiety signals. The expression of receptors for metabolic hormones, such as insulin, leptin, and ghrelin, allows ARC to sense information from the periphery and signal it to the central nervous system. The ventromedial ARC
Yi, Chun-Xia +5 more
openaire +4 more sources
The Suprachiasmatic Nucleus Modulates the Sensitivity of Arcuate Nucleus to Hypoglycemia in the Male Rat [PDF]
The suprachiasmatic nucleus (SCN) and arcuate nucleus (ARC) have reciprocal connections; catabolic metabolic information activates the ARC and inhibits SCN neuronal activity. Little is known about the influence of the SCN on the ARC. Here, we investigated whether the SCN modulated the sensitivity of the ARC to catabolic metabolic conditions.
Herrera-Moro Chao, D. +6 more
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Suprachiasmatic Nucleus Interaction with the Arcuate Nucleus; Essential for Organizing Physiological Rhythms [PDF]
AbstractThe suprachiasmatic nucleus (SCN) is generally considered the master clock, independently driving all circadian rhythms. We recently demonstrated the SCN receives metabolic and cardiovascular feedback adeptly altering its neuronal activity.
Frederik N. Buijs +6 more
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Obesity increases sympathetic nerve activity (SNA) in men, but not women. Here, we review current evidence suggesting that sexually dimorphic sympathoexcitatory responses to leptin and insulin may contribute.
Zhigang Shi +2 more
doaj +1 more source
Fetal alcohol exposure alters proopiomelanocortin gene expression and hypothalamic-pituitary-adrenal axis function via increasing MeCP2 expression in the hypothalamus. [PDF]
Proopiomelanocortin (POMC) is a precursor gene of the neuropeptide β-endorphin in the hypothalamus and is known to regulate various physiological functions including stress response.
Omkaram Gangisetty +3 more
doaj +1 more source
The connexions of the arcuate nucleus of the thalamus [PDF]
Abstract As the result of detailed anatomical study, the ventral nucleus of the mammalian thalamus has been shown to be a composite structure, consisting of several nuclear elements which are to be distinguished by their cell and fibre architecture, and also by their fibre connexions. It has been demonstrated that medial fillet fibres
openaire +1 more source
Peptidergic neurons synthesizing kisspeptin (KP) and neurokinin B (NKB) in the hypothalamic infundibular nucleus have been implicated in negative sex steroid feedback to GnRH neurons. In laboratory rodents, testosterone decreases KP and NKB expression in
Herczeg, László +11 more
core +1 more source
Glucose reverses fasting-induced activation in the arcuate nucleus of mice [PDF]
The hypothalamic arcuate nucleus is an important target for metabolic and hormonal signals controlling food intake. As demonstrated by c-Fos studies, arcuate neurons are activated in food deprived mice, while refeeding reverses the fasting-induced ...
Becskei, C +2 more
core +1 more source
Direct modulation of GFAP-expressing glia in the arcuate nucleus bi-directionally regulates feeding
Multiple hypothalamic neuronal populations that regulate energy balance have been identified. Although hypothalamic glia exist in abundance and form intimate structural connections with neurons, their roles in energy homeostasis are less known.
Naiyan Chen +7 more
doaj +1 more source

