Results 31 to 40 of about 366,068 (244)

QRFP-Deficient Mice Are Hypophagic, Lean, Hypoactive and Exhibit Increased Anxiety-Like Behavior. [PDF]

open access: yesPLoS ONE, 2016
How the hypothalamus transmits hunger information to other brain regions to govern whole brain function to orchestrate feeding behavior has remained largely unknown.
Kitaro Okamoto   +13 more
doaj   +1 more source

Hunger and Satiety Gauge Reward Sensitivity

open access: yesFrontiers in Endocrinology, 2017
Many of the neurocircuits and hormones known to underlie the sensations of hunger and satiety also substantially alter the activity of the dopaminergic reward system.
Ryan Michael Cassidy, Qingchun Tong
doaj   +1 more source

Investigating the role of arcuate nucleus and paraventricular nucleus glucokinase in glucose homeostasis [PDF]

open access: yes, 2020
The brain is as an important regulator of appetite and metabolism. Glucokinase (GK) is a key component of glucose sensing, and is expressed in many glucose sensitive neurones (Rosario et al., 2016, Pocai et al., 2005b).
Ratnasabapathy, Risheka
core   +1 more source

Glucose reverses fasting-induced activation in the arcuate nucleus of mice [PDF]

open access: yes, 2008
The hypothalamic arcuate nucleus is an important target for metabolic and hormonal signals controlling food intake. As demonstrated by c-Fos studies, arcuate neurons are activated in food deprived mice, while refeeding reverses the fasting-induced ...
Becskei, C   +5 more
core   +1 more source

Decreased serotonin transporter immunoreactivity in the human hypothalamic infundibular nucleus of overweight subjects

open access: yesFrontiers in Neuroscience, 2014
Context: That serotonin plays a role in the regulation of feeding behavior and energy metabolism has been known for a long time. Serotonin transporters (SERT) play a crucial role in serotonin signalling by regulating its availability in the synaptic ...
Anke eBorgers   +7 more
doaj   +1 more source

Prolyl carboxypeptidase in Agouti-related Peptide neurons modulates food intake and body weight

open access: yesMolecular Metabolism, 2018
Objective: Prolyl carboxypeptidase (PRCP) plays a role in the regulation of energy metabolism by inactivating hypothalamic α-melanocyte stimulating hormone (α-MSH) levels.
Giuseppe Bruschetta   +3 more
doaj   +1 more source

Neuropeptide Y and Metabolism Syndrome: An Update on Perspectives of Clinical Therapeutic Intervention Strategies

open access: yesFrontiers in Cell and Developmental Biology, 2021
Through the past decade of research, the pathogenic mechanisms underlying metabolic syndrome have been suggested to involve not only the peripheral tissues, but also central metabolic regulation imbalances.
Yinqiong Huang   +3 more
doaj   +1 more source

Hypertrophy of the Anterior External Arcuate Fasciculus: A Rare Variant With Implications for the Development of the Arcuate Nucleus

open access: yesFrontiers in Neuroanatomy, 2020
A rare anatomic variant of a markedly enlarged anterior external arcuate fasciculus (AEAF) on the ventral medullary surface is reported and compared to two controls. The hypertrophic AEAF was nine times larger in diameter than normal, whereas the arcuate
Renee Stonebridge   +7 more
doaj   +1 more source

Obesity: sex and sympathetics

open access: yesBiology of Sex Differences, 2020
Obesity increases sympathetic nerve activity (SNA) in men, but not women. Here, we review current evidence suggesting that sexually dimorphic sympathoexcitatory responses to leptin and insulin may contribute.
Zhigang Shi   +2 more
doaj   +1 more source

Fetal alcohol exposure alters proopiomelanocortin gene expression and hypothalamic-pituitary-adrenal axis function via increasing MeCP2 expression in the hypothalamus. [PDF]

open access: yesPLoS ONE, 2014
Proopiomelanocortin (POMC) is a precursor gene of the neuropeptide β-endorphin in the hypothalamus and is known to regulate various physiological functions including stress response.
Omkaram Gangisetty   +3 more
doaj   +1 more source

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